DFP treatment of iMEFs. by Holly J. Garringer (281855)

“…<p>Cell viability of iron loaded iMEFs (3 days with 100 μM iron) increased considerably after 3 days of DFP exposure (A). …”

Results of phantom eye model. by Makoto Shirasawa (438600)

“…<p>Representative SD-OCT images of phantom eye model (A–C). A, ART = 1; B, ART = 20; C, ART = 100. ART =  number of frames averaged. …”

Sampling design. by Kiwako S. Araki (680112)

“…Vegetation cover data was used as a measure of environmental heterogeneity (a), and the spatial distribution of genets (groups of clonal ramets with shared genotypes) was determined through simple sequence repeat (SSR) analyses (b). …”

Tuning the Attempt Frequency of Protein Folding Dynamics via Transition-State Rigidification: Application to Trp-Cage by Rachel M. Abaskharon (1351644)

“…We find that this strategy not only decreases the folding time of the Trp-cage peptide by more than an order of magnitude (to ∼100 ns at 25 °C) but also exposes parallel folding pathways, allowing us to provide, to the best of our knowledge, the first quantitative assessment of the curvature of the transition-state free-energy surface of a protein.…”

Prevalence and rate of reversion of RT mutations at baseline (BL), 2 months (2mo) and 4 months (4mo) Structured Treatment Interruption (STI) and associated changes in Replication C... by Agnes C. Paquet (231161)

“…Between 2 months and 4 months of STI, the reversion of mutations was also associated with an increase in RC, although of a lesser magnitude since RC was already close to 100% at 2 months (data not shown).…”

Constructions of tryptase lentivirus carrier and tryptase siRNA lentivirus carrier. by Xiuling Zhi (397887)

“…Same fields of vision under an optical microscope(×100). More than 80% cells were infected with lent-GFP at a dose of MOI 10 after 48 h treatment. …”

Knockdown of PTEN in NMECs generates disorganized hyperplastic lesions in humanized NOD/SCID mice. by Hasan Korkaya (159560)

“…Outgrowths with PTEN knockdown showed increased CK5/6 expression (c and j) and decreased CK18 expression (d and k), as well as a lack of ERα expression compared to control cells (e and l). …”

Hypoglycemic property of triterpenoid saponin PFS isolated from Polyscias fruticosa leaves by NGUYEN THI LUYEN (5835887)

“…In the sucrose tolerance test, PFS at 100 mg/kg body weight significantly decreased the postprandial blood glucose level in mice fed a high-sucrose diet. …”

Study Design Subgroup Analyses by Corey Simpson (18475386)

“…</b> The three cohort studies showed a statistically significant decreased association with skin cancer (HR 0.88, 95% CI 0.78-0.99) and high study heterogeneity (<i>I</i>² 79%). …”

The <i>fat-7</i> desaturase is regulated by <i>paqr-2</i> and its suppressors. by Emma Svensk (458231)

“…<p>(<b>A</b>) The <i>paqr-2</i> mutant has decreased expression of <i>fat-7</i>, while strains carrying the <i>paqr-2</i> suppressors <i>nhr-49(et8)</i> or <i>cept-1(et10)</i> show a marked increase in <i>fat-7</i> expression when compared to control worms (wt). …”

IL-12 has opposite effects on IL-2R expression by Tregs vs non-Treg T cells. by Jingxian Zhao (258023)

“…<p>Lymphocytes were prepared from naïve <i>Foxp3^gfp</i> mice and treated with anti-CD3 mAb and IL-12 or IFN-γ for 66 hr. (A, B) CD25 expression was decreased on Tregs and increased on Tconvs and CD8 T cells by IL-12 in a dose-dependent fashion. …”

Predicted changes in species overlap with increasing temperatures. by Mary E. Hunsicker (422709)

“…<p>Predicted increases in predator and prey occurrences (black circles) and probability of species overlap (red circles) with a standardized unit increase in spatially explicit bottom temperatures in the early regime (based on year 1987; A, overlap; C, flounder; E, juvenile pollock) and late regime (based on year 2005; B, overlap; D, flounder; F, juvenile pollock). …”

Thapsigargin versus glucose deprivation and F7 mRNA expression. by Katherine R. Cronin (146594)

“…Expression at 25 mM glucose and without thapsigargin were considered 100% expression for each amplicon; other groups were expressed as a percentage +/− SD relative to this. …”

Time-Response EEG activity of SR9009 during the light phase. by Ariadna Amador (2560231)

“…Mice were dosed with SR9009 at different time points (ZT3, ZT6, and ZT9) on separate days in order to generate a Time-Response Curve. (<b>B</b>) Injections with SR9009 (i.p. 100mg kg^-1) induced wakefulness at ZT6 (p<0.05), but not ZT3 and ZT9, reduced SWS at ZT6 (p<0.05), but not ZT3 and ZT9, and decreased significantly REM sleep at ZT3 (p<0.05), and ZT6 (p<0.05), but not at ZT9. …”

H&E stained histological evaluation of mouse lungs in the control, PQ, PQ + low-dose APN, and PQ + high-dose APN groups on days 3, 7, 14, 21 after PQ injection (×200 magnification)... by Rong Yao (735448)

“…<p>Compared with control group, PQ (10 mg/kg) intoxication showed progressively interstitial edema and inflammatory cell infiltration in the alveolar space and septum from day 3, reaching a peak on day 14. Both low high-dose (100 μg/kg) and high-dose (500 μg/kg) APN groups showed remarkably decreased interstitial edema and inflammatory cell infiltration, in a dose-dependent manner.…”

Direct Observation of Strand Passage by DNA-Topoisomerase and Its Limited Processivity by Katsunori Yogo (172528)

“…The time elapsed before the start of processive unlinking decreased with the enzyme concentration, being ∼100 s at 3.7 pM. …”

Effect of Sonication Time on Degree of Chromatin Shearing in Fresh or Frozen Cell Suspensions. by Pamela D. Schoppee Bortz (199468)

“…Final DNA concentrations were determined via nanospectrophotometry; 2 µg of DNA per time point was used to evaluate the effect of shearing by electrophoresis in a 1% agarose gel (<b>A</b>). A small volume (7.5 µl) of unsonicated, unextracted sample (0 min) was also electrophoresed for comparison (<b>M</b>: a 100 base-pair DNA marker). …”

Performance Tradeoffs Associated with Feedback Strategies by Arthur D Lander (82004)

“…</p> <p>(F) Example of a case with both activin and GDF11 feedback. Notice that now, regeneration from initial conditions of 75% ORN depletion is nearly as fast as regeneration from 100% ORN depletion (compare with [C]). …”

Evaluation of the immunomodulatory activity of thalidomide on tumor-associated macrophages in the 4T1 murine metastatic breast cancer model by D.C. Reis (4770336)

“…<div><p>ABSTRACT The present work evaluated the immunomodulatory effect of thalidomide (Thal) at different doses on tumor-associated macrophages (TAMs) using a mouse model of human breast cancer. Mice were inoculated with 4T1 cells in the left flank and treated with Thal once a day at concentrations of 50, 100, and 150mg/kg body weight from the 5th day until the 28th day of tumor inoculation. …”

Oxidative stress assessed by 4-HNE staining. by Kanako Tamura (734618)

“…Data are means ± SEM of 4–5 mice in each group. *<i>p</i> < 0.05, **<i>p</i> < 0.01</p>…”