Differential microRNA expression in human placentas of term intra-uterine growth restriction that regulates target genes mediating angiogenesis and amino acid transport by Shanthie Thamotharan (3992894)

“…Finally to establish functional significance we performed dual-luciferase reporter assays with 3’-insertion of <i>miR-10b</i> alone and observed a ~10% reduction in the 5’-luciferase activity versus the control. …”

<i>In cellulo</i> Evaluation of Phototransformation Quantum Yields in Fluorescent Proteins Used As Markers for Single-Molecule Localization Microscopy by Sergiy Avilov (575857)

“…To this aim, we developed a data processing strategy based on the clustering optimization procedure proposed by Lee et al (PNAS 109, 17436–17441, 2012). …”

Functional connectivity revealed by rsfcMRI. by Corinna M. Bauer (3854026)

Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function by Jonathan J. Cherry (501180)

Changes in connectivity strength and network metrics during resting state and task periods. by Thomas P. K. Breckel (455915)

“…Attentionally resilient subjects (blue) began to recover during the post-task phase and showed a decrease in functional connectivity in the direction of the pre-task values, whereas attentionally impaired subjects (red) showed further increases in global connectivity strength until the end of the measurement (see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074125#pone-0074125-g005" target="_blank">Figure 5</a> A). …”

Increased aerobic glycolysis in MADD fibroblasts and <i>xav</i> mutants. by Yuanquan Song (238595)

“…<p><b>A.</b> ECAR was measured in intact control and MADD Patient 1 fibroblasts under basal conditions, following the addition of the mitochondrial inhibitor oligomycin (0.5 µg/ml), in the presence of the uncoupler CICCP (3 µM) and following the addition of the complex I inhibitor rotenone (100 nM). …”

Vulnerability to high fat diet-induced obesity. by Alessandro Bartolomucci (165364)

“…At baseline, when mice were fed standard diet, all experimental groups showed a decrease in body weight, while controls (Con) showed a slight increase (F(3,23) = 3.2, p<0.05). …”

Endometriosis Is Associated with Rare Copy Number Variants by Rakesh Chettier (73475)

“…Three CNV's passed a genome-wide P-value threshold of 9.3×10⁻⁴; a deletion at <i>SGCZ</i> on 8p22 (P = 7.3×10⁻⁴, OR = 8.5, Cl = 2.3–31.7), a deletion in <i>MALRD1</i> on 10p12.31 (P = 5.6×10⁻⁴, OR = 14.1, Cl = 2.7–90.9), and a deletion at 11q14.1 (P = 5.7×10⁻⁴, OR = 33.8, Cl = 3.3–1651). …”

Measurement of mitochondrial function in nasal fibroblasts with and without TGF-β1 or with and without PX-478 To investigate whether mitochondrial function are elevated by TGF-β1,... by Min-Sik Jo (14636809)

“…<p>Oxygen consumption rate (OCR) was significantly increased at 5 ng/ml TGF-β1 (S1A Fig). To determined whether PX-478 decrease mitochondrial function, PX-478 (20 nM) was pretreated for 1 hour, followed by TGF-β1 48 hours. …”

Modelling of the effects of En1 and En2 on hippocampal cells. by Asma Soltani (4356841)

“…In normal conditions (black lines), low levels of endogenous secreted En1 (from GABA cell for instance) could participate to dendritogenesis (1), spinogenesis (2) (insert), and mTOR signaling (3) in neighbor glutamatergic neurons. In a pathological context, such as autism (red lines), a rise of En2 expression and secretion would generate additional effects, i.e. the increase in dendritic complexity of GABA cells (4), a decrease of clustered PSD95 (5), and the mispairing of glutamatergic synapses (6) (insert). …”

An immunohistochemically stained photomicrograph of the stomach mucosa using an anti-TLR4 antibody. by Rehab F. Taher (20478600)

“…<p>(a) few TLR4-positively stained cells in the normal group; (b) the control ethanol group showed elevated TLR4 expression and a higher proportion of positive cells having deep brown coloring, (c) Omeprazole group showed reduction in the percentage of TLR4 positive cells with strong brown coloring, (d) PM-EtOH (25 mg/kg) group showed lowered percentage of TLR4 positive cells with weak cytoplasmic staining, (e) PM-EtOH (5o mg/kg) group showed decreased percentage of TLR4 positive cells, (f) PM-EtOH (100 mg/kg) group giving weak TLR4 expression, with a significant decrease in TLR4-positively stained cells(TLR4 immunohistochemical staining; Scale bar=100µm).…”

Circular Dichroism analysis, PPIase activity and nickel regulation of <i>H</i>. <i>pylori</i> WT and mutant SlyD proteins. by Milica Denic (9987685)

“…<p><b>A.</b> Circular Dichroism spectra of SlyD wild type and mutant proteins were analyzed in 5 mM phosphate buffer (pH = 7.6). …”

Representative kinetic traces illustrating the JRA-associated abnormality in metabolic oscillations of neutrophils by James N Jarvis (3342)

“…However, in contrast to MPO-negative cells, MPO-positive cells undergo both a decrease in period to 10 seconds and a dramatic increase in the oscillatory amplitude. …”

Changes in Expression Levels of miR-1 and miR-133 and their targets in canine HF Myocytes. by Andriy E. Belevych (338034)

“…*p<0.05, n = 5. C. Representative Western blots of putative targets of miR-1 and -133, regulatory subunits B56α, B56δ and catalytic subunit of PP2A respectively. …”

Lab 3: Biol2050 Abundance and Diversity in Insects Data Set 1 by Katrin Chapkis (797943)

“…When the wind speed was found in the Beaufort scale, it was given a Beaufort number of 5, which corresponded to Fresh Breeze in Seaman's term.…”

Stimulation-induced changes in STN power. by Damian M. Herz (16007088)

“…Stimulation led to an approximately 40% decrease in beta power, which returned to baseline after approximately 0.5 s (mean burst duration was 250 ms +/− 100 drawn from a uniform distribution). …”

SPARC effect on ECM proteins in differentiating myoblasts. by Aicha Melouane (4530787)

“…A decrease of fibronectin expression with rSPARC and an increase after anti-SPARC were observed. …”

Differentially expressed genes by the risk alleles at 29 Mb and 33 Mb play important role in T-cell immunity. by Noriko Tonomura (227263)

“…<p>A. The risk allele at the 29 Mb at homozygous state has a clear cis-regulation effect on the expression levels of <i>TRPC6</i>, <i>KIAA1377</i>, and <i>ANGPTL5</i>, three of the most proximal genes. …”

Supplemental Figure 16 by Jill Hikspoors (11718656)

“…<div><b>article 'A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development'</b></div><div><b><br></b></div><i>Supplemental Figure 16. …”

VPA and NAM treatment modulates H3K27 acetylation at the promoters of myeloid specific genes. by Marije Bartels (532852)

“…At day 4 of differentiation, cells were treated overnight with 200μM, or 5mM NAM. Next, lysates were prepared, followed by ChIP-sequencing (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0196400#sec002" target="_blank">Methods</a>). …”