Image_3_Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders.TIF by Julia I. Ellyard (7369643)

“…We observed differences between unaffected and affected TACI mutants (increased B cells and CD8+ T-effector memory cells, loss of B-SM cells and non-classical monocytes), cellular signatures that distinguished CTLA4 haploinsufficiency itself (expansion of plasmablasts, activated CD4+ T cells, regulatory T cells, and X5-Th cells) from its clinical expression (B-cell depletion), and those that were associated with CARD11 gain-of-function mutation (decreased CD8+ T effector memory cells, B cells, CD21-lo B cells, B-SM cells, and NK cells). …”

Data_Sheet_1_Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders.PDF by Julia I. Ellyard (7369643)

“…We observed differences between unaffected and affected TACI mutants (increased B cells and CD8+ T-effector memory cells, loss of B-SM cells and non-classical monocytes), cellular signatures that distinguished CTLA4 haploinsufficiency itself (expansion of plasmablasts, activated CD4+ T cells, regulatory T cells, and X5-Th cells) from its clinical expression (B-cell depletion), and those that were associated with CARD11 gain-of-function mutation (decreased CD8+ T effector memory cells, B cells, CD21-lo B cells, B-SM cells, and NK cells). …”

Image_1_Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders.TIF by Julia I. Ellyard (7369643)

“…We observed differences between unaffected and affected TACI mutants (increased B cells and CD8+ T-effector memory cells, loss of B-SM cells and non-classical monocytes), cellular signatures that distinguished CTLA4 haploinsufficiency itself (expansion of plasmablasts, activated CD4+ T cells, regulatory T cells, and X5-Th cells) from its clinical expression (B-cell depletion), and those that were associated with CARD11 gain-of-function mutation (decreased CD8+ T effector memory cells, B cells, CD21-lo B cells, B-SM cells, and NK cells). …”

Image_4_Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders.TIFF by Julia I. Ellyard (7369643)

“…We observed differences between unaffected and affected TACI mutants (increased B cells and CD8+ T-effector memory cells, loss of B-SM cells and non-classical monocytes), cellular signatures that distinguished CTLA4 haploinsufficiency itself (expansion of plasmablasts, activated CD4+ T cells, regulatory T cells, and X5-Th cells) from its clinical expression (B-cell depletion), and those that were associated with CARD11 gain-of-function mutation (decreased CD8+ T effector memory cells, B cells, CD21-lo B cells, B-SM cells, and NK cells). …”

Image_2_Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders.TIF by Julia I. Ellyard (7369643)

“…We observed differences between unaffected and affected TACI mutants (increased B cells and CD8+ T-effector memory cells, loss of B-SM cells and non-classical monocytes), cellular signatures that distinguished CTLA4 haploinsufficiency itself (expansion of plasmablasts, activated CD4+ T cells, regulatory T cells, and X5-Th cells) from its clinical expression (B-cell depletion), and those that were associated with CARD11 gain-of-function mutation (decreased CD8+ T effector memory cells, B cells, CD21-lo B cells, B-SM cells, and NK cells). …”

Data_Sheet_2_Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders.PDF by Julia I. Ellyard (7369643)

“…We observed differences between unaffected and affected TACI mutants (increased B cells and CD8+ T-effector memory cells, loss of B-SM cells and non-classical monocytes), cellular signatures that distinguished CTLA4 haploinsufficiency itself (expansion of plasmablasts, activated CD4+ T cells, regulatory T cells, and X5-Th cells) from its clinical expression (B-cell depletion), and those that were associated with CARD11 gain-of-function mutation (decreased CD8+ T effector memory cells, B cells, CD21-lo B cells, B-SM cells, and NK cells). …”

Data_Sheet_3_Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders.PDF by Julia I. Ellyard (7369643)

“…We observed differences between unaffected and affected TACI mutants (increased B cells and CD8+ T-effector memory cells, loss of B-SM cells and non-classical monocytes), cellular signatures that distinguished CTLA4 haploinsufficiency itself (expansion of plasmablasts, activated CD4+ T cells, regulatory T cells, and X5-Th cells) from its clinical expression (B-cell depletion), and those that were associated with CARD11 gain-of-function mutation (decreased CD8+ T effector memory cells, B cells, CD21-lo B cells, B-SM cells, and NK cells). …”

Canine cardiac slices are viable for >7 days in culture. by Asma Boukhalfa (14803385)

“…<p>A. No significant reduction in adult canine cardiac slice viability through 14 days of culturing (arrow) by MTT staining was noted. …”

Oral health self-perception evaluation using mandibular overdenture prosthesis in public health care by Fábio Antonio Villa NOVA (6117872)

“…For statistical analysis, exploratory data analysis was initially performed and then the nonparametric Wilcoxon test was applied considering a significance level of 5%. Results: The average age of the sample was 57.6 years old (SD=9.0) with a minimum age of 43 and maximum of 74 years old. …”

Video_1_Breaking All the Rules: The First Recorded Hard Substrate Sessile Benthic Community Far Beneath an Antarctic Ice Shelf.mp4 by Huw J. Griffiths (9468143)

“…<p>The seafloor beneath floating ice shelves accounts roughly a third of the Antarctic’s 5 million km² of continental shelf. …”

Schematic representation showing different phases and outcomes of stochastic bubbles for (4) with <i>b</i> = 0.42, <i>g</i> = −0.04, <i>σ</i>_<i>x</i> = 0.6, <i>σ</i><sub... by Damian Smug (5040890)

“…<b>(A)</b> and <b>(B)</b> Foreshocks {1/2} and {3/4} preceding the main crash {5/6} are clearly visible. …”

Effect of Broiler Crating Density and Transportation Distance on Preslaughter Losses and Physiological Response During the Winter Season in Punjab, Pakistan by F Hussnain (6699911)

“…<div><p>ABSTRACT A study was conducted to determine the impact of crating density and transportation distance on losses and physiological response of broilers during the winter season. …”

<i>Smed-not1(RNAi)</i> animals maintain mitotic neoblasts. by Jordi Solana (499882)

“…<p>(A) Quantification of mitosis by counting of h3p-positive cells in whole mount immunohistochemistry on <i>control(RNAi)</i> and <i>Smed-not1(RNAi)</i> animals 5, 10, 15 and 20 days after RNAi (N = 7 per time point). …”

Evolution of mutation rates on simple fitness landscapes with different ruggedness. by Jeff Clune (53764)

“…Although the optimal mutation rate increases as a function of valley size (note the right-shift in the dashed line from top to bottom), the evolved mutation rates in fact decrease as a function of valley size (note the left-shift of the blue and red points from top to bottom).…”

Supplementary Material for: High flow oxygen does not improve oxygenation during rigid medical thoracoscopy by figshare admin karger (2628495)

“…The average SpO2 (96.3% vs 96.2%, p=0.81) was similar between groups. There was a tendency towards a higher peak PtcCO2 in the conventional oxygen group (49.6 mmHg vs 55.5 mmHg, p=0.13). …”

Soil Water Potentials and Capsicum annuum L. under Salinity by Heitor Henrique Félix Duarte and (12700699)

“…An experiment was developed using bell pepper in a Neossolo Flúvico (Fluvent) irrigated with water of six levels of electrical conductivity (0, 1, 3, 5, 7 and 9 dS m-1) by using exclusively NaCl and by simulating the actual condition (using a mixture of salts). …”

Age-dependent distribution of three division modes of HSCs. by Teiko Kawahigashi (17867328)

“…<b>(B)</b> The age-related number of CD34^-CD150⁺KSL cells (HSCs, left) and KSL cells (HSCs and progenitor cells, right) in femur predicted by the mathematical model (<b>Eqs (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0292575#pone.0292575.e005" target="_blank">5</a>)</b> and <b>(<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0292575#pone.0292575.e006" target="_blank">6</a>)</b>) with best-fit parameters and the experimental data are shown. …”

VEGF presentation and trafficking control the distribution of ligated VEGFR2. by Lindsay Wendel Clegg (754229)

“…Note that, due to degradation, the total amount of VEGFR2 decreases after addition of VEGF. [V] = 20 ng/mL. D. …”

Induction of ssDNA at human telomeres. by Remco P. Crefcoeur (3611735)

“…Untransfected, sgControl-, and sgTelomere-transfected cells showed, respectively, 5%, 4%, and 50% colocalization. A total number of 100 cells were counted (p<0.00001).…”

IGFBP3 inhibits HCRT production <i>in vivo</i> and <i>in vitro</i>. by Makoto Honda (102165)

“…<p>(A, B) Hypocretin-1 peptide content is significantly decreased in both hypothalamus and brainstem of IGFBP3 overexpressing transgenic mice (h<i>IGFBP3</i> TG). …”