Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Detection of the Challenging mutations at 1% VAF and 50 ng DNA input. حسب Lizhi Yu (12476136)

Overexpressions of the AB domain of RPA70 and the β-barrel domain of Ku70 significantly decrease HBoV1 replication in HAE-ALI. حسب Kang Ning (59789)

Results isoprenaline (30nM) experiment. حسب L. Cao (3526226)

Effectiveness of interventions to decrease hesitancy. حسب Maximilian Nicolaus Burger (12969212)

Rotenone exposure decreases GSH level in porcine oocytes. حسب Geun Heo (14185618)

The fraction of predicted heterozygotes that are set to “No Call” by RHA decreases as the size of the heterozygote cluster increases. حسب Orna Mizrahi-Man (42539)

Genes whose expression was decreased by 1 mM ouabain by more than 2-fold. حسب Larisa V. Smolyaninova (3600053)

Scenario (6): Parameter variation (50% decrease)—With 5 N.m load applied at t = 0.3s. حسب Djaloul Karboua (16510091)

"…<p>Scenario (6): Parameter variation (50% decrease)—With 5 N.m load applied at t = 0.3s.</p>…"

Performance of selected antimalarials against field isolates during the study period. حسب Winnie Okore (14139712)

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Primers used for analysis of four SNPs in one gene. حسب Winnie Okore (14139712)

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Number of samples per site during the study period. حسب Winnie Okore (14139712)

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Performance of selected drugs against field isolates during the study period. حسب Winnie Okore (14139712)

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<i>In vitro</i> susceptibility responses of field isolates to antimalarials during the study period. حسب Winnie Okore (14139712)

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<i>Pfmrp1</i> gene SNPs data during the study period. حسب Winnie Okore (14139712)

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Frequency of SNPs in <i>Pfmrp1</i> gene in field isolates during the study period. حسب Winnie Okore (14139712)

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<i>In vitro</i> 95% CI lower and upper mean susceptibility responses of field isolates to antimalarials. حسب Winnie Okore (14139712)

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Conditional <i>Aff4</i> knockout decreases fat mass in mice. حسب Yaqian Chen (1711576)

Nicotine decreased Akt phosphorylation in SK-BR-3 cells. حسب Masanori A. Murayama (5774585)

Treatment with low doses of GI254023X causes a mild decrease in ADAM10 surface expression that correlates with a marked impairment of HCV infectivity. حسب Belén Carriquí-Madroñal (17396512)