Albumin Decrease Is Associated with Spontaneous Preterm Delivery within 48 h in Women with Threatened Preterm Labor by Yujing J. Heng (1696339)

Albumin Decrease Is Associated with Spontaneous Preterm Delivery within 48 h in Women with Threatened Preterm Labor by Yujing J. Heng (1696339)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Fig 10 - by Farshid Maleki (20521649)

The injectable contraceptives depot medroxyprogesterone acetate and norethisterone enanthate substantially and differentially decrease testosterone and sex hormone binding globulin... by Chanel Avenant (409756)

“…Both contraceptives substantially decreased, from D0 to 25W, the total testosterone [DMPA-IM D0 0.560, 25W 0.423 nmol/L, -24.3% (p < 0.0001); NET-EN D0 0.551, 25W 0.253 nmol/L, -54.1%, (p < 0.0001)], SHBG [DMPA-IM D0 45.0, 25W 32.7 nmol/L, -29.8% (p < 0.0001); NET-EN D0 50.2, 25W 17.6 nmol/L, -65.1% (p < 0.0001)], and calculated free testosterone levels [DMPA-IM D0 6.87, 25W 5.38 pmol/L, -17.2% (p = 0.0371); NET-EN D0 6.00, 25W 3.70, -40.0% (p < 0.0001)]. …”

MSC treatment does not affect chronic LPS-induced decreased lung function. by P. Padmini S. J. Khedoe (4436458)

Antibodies used for flow cytometry experiments. by Joseph Rabin (7399436)

Subjects:

Subject flow diagram. by Joseph Rabin (7399436)

Subjects:

Extracellular adenosine modulates host-pathogen interactions through regulation of systemic metabolism during immune response in <i>Drosophila</i> by Adam Bajgar (730380)

Forced WNT10A expression and WNT10A siRNA knockdown in kidney cell lines. by Ren-Jun Hsu (127121)

“…Conversely, RCC-1 and Caki-1 transfected with WNT10A siRNA showed significant decrease in cell proliferation as compared to cells transfected with reagent and scrambled siRNA controls. …”

Compound CID 9998128 Is a Potential Multitarget Drug for Alzheimer’s Disease by Nguyen Quoc Thai (5348798)

“…Moreover, the compound dose-dependently decreases β-site amyloid precursor protein cleaving enzyme (BACE-1) activity with EC₅₀ value in micromolar range. …”

Compound CID 9998128 Is a Potential Multitarget Drug for Alzheimer’s Disease by Nguyen Quoc Thai (5348798)

“…Moreover, the compound dose-dependently decreases β-site amyloid precursor protein cleaving enzyme (BACE-1) activity with EC₅₀ value in micromolar range. …”

Comparison of the decrease of CFU in CSF and blood between treatment groups within the first 6 h after treatment. by Luca G. Valente (12463057)

Downregulation of DOM decreases the abundance of PER and TIM. by Zhenxing Liu (399809)

Resveratrol decreases proliferation of Cisplatin-sensitive A2780 cells but not Cisplatin-resistant A2780CP cells. by Sébastien Baribeau (512869)

“…<p>MTT assay was performed to evaluate A2780 and A2780 cell lines proliferation in response to 10 µM Cisplatin and increasing doses up to 60 µM of Resveratrol. …”

Loss of <i>flp-1</i> decreases the nose touch response. by Ingrid Buntschuh (4729536)

“…<p>All <i>flp-1</i> and <i>daf-10</i> mutant alleles showed a decreased nose touch response. …”

Elevated S100A8 level in BALF is associated with an increase of BALF neutrophils and a decrease of physiological function. by Do Hyung Kim (739231)

HDAC1 knockdown significantly increases RGS10 expression while HDAC1 overexpression decreases RGS10 expression in chemoresistant ovarian cancer cells. by Ercan Cacan (393523)

“…<p><b>A)</b> Knockdown of HDAC1 increases RGS10 mRNA transcription. …”

The PittII Msf-KO strain has decreased survival in macrophages. by Jennifer M. Kress-Bennett (3179382)