Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

“…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC₅₀ 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”

TNFα, MIP-1α, and MCP-1 are decreased and anti-inflammatory cytokine IL-10 is increased by MSC treatment. by Shibani Pati (208746)

“…<p>Blood was drawn at two hours post-hemorrhage and analyzed for serum levels of TNFα, MCP-1, IL-10 and MIP-1α. As shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025171#pone-0025171-g005" target="_blank">Figures 5A–C</a>, bioplex analysis of serum shows that MCP-1, TNFα, and MIP-1α all significantly increase after HS and HS+LR. …”

MYCN overexpression leads to decreased <i>id2a</i> expression in early SCG. by Rodrigo Ibarra-García-Padilla (19697623)

3-HPA and the 10-fold diluted reuterin-containing supernatant significantly decreased the <i>S.</i> Typhimurium χ3339 population. by Rosemarie De Weirdt (320666)

Enhanced dendritic cell percentages and activation and decreased IL-10 expressing dendritic cells after agonistic anti-TIGIT treatment. by Amanda C. Foks (302836)

Incubation of <i>T</i>. <i>brucei</i> with Pol I transcription inhibitors results in a dramatic decrease in VEX1 foci. by Louise E. Kerry (3815164)

Tau phosphorylation is decreased in neurons treated with 20 mM KCl. by Nguyen-Vi Mohamed (323606)

The minimal data set 10. by Esete Habtemariam Fenta (9727779)

Statistical details of data presented in Fig 16. by Piotr Popik (292215)

“…<div><p>The rapid decrease of light intensity is a potent stimulus of rats’ activity. …”

Statistical details of data presented in Fig 17. by Piotr Popik (292215)

“…<div><p>The rapid decrease of light intensity is a potent stimulus of rats’ activity. …”

Simon Nilsson’s polygon features in action. by Piotr Popik (292215)

“…<div><p>The rapid decrease of light intensity is a potent stimulus of rats’ activity. …”

Decreased processivity of A3G NPM was attributable to changes in sliding, but not jumping movements. by Anjuman Ara (540372)

Kif2a accumulation at the base of <i>Ttbk2</i>^{<i>sca11/gt</i>} cilia causes instability. by Emily Bowie (543704)

Enrichment of TICs decreases PP2A activity and increases Hsp27 activation in other solid tumors. by Shih-Pei Lin (117914)

The loss of Sad kinases leads to a decrease in the number of neuronal progenitors in the cortex. by Pratibha Dhumale (5146484)

Pretreatment with Y-26732 Decreased Caspase-3 Activity in CSCs Induced by Dox. by Lijuan Kan (834976)

The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits - Fig 8 by Jin Zhou (90734)

The novel <i>carboxylesterase 1</i> variant c.662A>G may decrease the bioactivation of oseltamivir in humans by Jaeseong Oh (3947381)

“…A novel <i>CES1</i> c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease CES1 enzymatic activity in an <i>in silico</i> analysis. …”

(A) Kaplan-Meier survival curves showing 28-day survival rates between the two groups;(B) ROC analysis of death risk factors in SFTS patients with HLH. by Bo Zhang (6559)

The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits - Fig 4 by Jin Zhou (90734)