Variability and correlations are quenched in large-scale network models (300 regions) with both random and clustered structural connections. by Takuya Ito (57473)

“…<b>l-n)</b> The same analyses as <b>b-d</b>, but using the clustered connectivity matrix with 100% E connections. Boxplots indicate the interquartile range of the distribution, dotted black line indicates the mean, and the distribution is visualized using a swarm plot. …”

Effects of U0126, T0070907, and Pioglitazone hydrochloride (Pio) on NO production in LPS-stimulated RAW264.7 macrophages. by Xiang Li (114679)

“…ENL does-dependently attenuated NO secretion, U0126, T0070907, and Pio further strengthened ENL's effect. 50 µM SDL also showed NO inhibition activity, while U0126 enhanced SDL's effect. * Means compared with model group (200 ng/ml LPS treated alone), and # stands for statistic significance analysis between two groups with and without small molecular tool drugs (<i>i.e.…”

Possible roles of sestrin2 in multiple sclerosis and its relationships with clinical outcomes by Faruk Omer ODABAS (12652740)

“…In the ROC analysis of SESN2, the predictive level for MS was 2.36 ng/mL [sensitivity, 72.50%; specificity, 55.56%; p=0.002; area under the curve (AUC)=0.693]. …”

Table_1_The Immunologic Effect of Early Intravenous Two and Four Gram Bolus Dosing of Tranexamic Acid Compared to Placebo in Patients With Severe Traumatic Bleeding (TAMPITI): A Ra... by Philip C. Spinella (5181788)

“…Background<p> The hemostatic properties of tranexamic acid (TXA) are well described, but the immunological effects of TXA administration after traumatic injury have not been thoroughly examined. We hypothesized TXA would reduce monocyte activation in bleeding trauma patients with severe injury.…”

Image_1_The Impact of Multimorbidity Burden, Frailty Risk Scoring, and 3-Directional Morphological Indices vs. Testing for CSF Responsiveness in Normal Pressure Hydrocephalus.JPEG by Shereen X. Y. Soon (9569062)

The Cost-Effectiveness of Intermittent Preventive Treatment for Malaria in Infants in Sub-Saharan Africa by Lesong Conteh (231114)

DataSheet1_The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells.ZIP by Hai-Ling Gao (9501677)

“…However, MK-2206 (0.3 and 1 μM) significantly increased the anticancer efficacy of mitoxantrone, SN-38 and topotecan, in H460/MX20 and S1-M1-80 cancer cells, as indicated by a significant decrease in their IC50 values, compared to cells incubated with vehicle. …”

Data_Sheet_1_Excess Mortality in Italy During the COVID-19 Pandemic: Assessing the Differences Between the First and the Second Wave, Year 2020.PDF by Maria Dorrucci (252694)

“…During the first wave (25th February−31st May), we estimated 52,437 excess deaths (95% CI: 49,213–55,863) and 50,979 (95% CI: 50,333–51,425) during the second phase (10th October−31st December), corresponding to percentage 34.8% (95% CI: 33.8%–35.8%) in the second wave and 31.0% (95%CI: 27.2%–35.4%) in the first. …”

Results of the Implementation of a Pilot Model for the Bidirectional Screening and Joint Management of Patients with Pulmonary Tuberculosis and Diabetes Mellitus in Mexico by Martín Castellanos-Joya (630597)

Data_Sheet_2_Excess Mortality in Italy During the COVID-19 Pandemic: Assessing the Differences Between the First and the Second Wave, Year 2020.PDF by Maria Dorrucci (252694)

“…During the first wave (25th February−31st May), we estimated 52,437 excess deaths (95% CI: 49,213–55,863) and 50,979 (95% CI: 50,333–51,425) during the second phase (10th October−31st December), corresponding to percentage 34.8% (95% CI: 33.8%–35.8%) in the second wave and 31.0% (95%CI: 27.2%–35.4%) in the first. …”

Inhibition of Aurora kinases by MLN8237 impairs germinative cell maintenance and larval growth of <i>E. multilocularis</i>. by Zhe Cheng (397373)

“…<p>(A) Long-term MLN8237 treatment eliminates germinative cell populations. …”

Neurochemical identity of dFB^23E10Ո^84C10 neurons. by Joseph D. Jones (13883524)

“…<b>(K)</b> Box plots of total sleep change in % ((total sleep on activation day-total sleep on baseline day/total sleep on baseline day) × 100) for control (<i>Empty-Split>CsChrimson</i>), <i>VGlut-AD; 84C10-DBD>CsChrimson</i> and <i>84C10-AD; ChAT-DBD>CsChrimson</i> female flies under a 50 Hz optogenetic activation protocol. …”

The Native <em>Wolbachia</em> Endosymbionts of <em>Drosophila melanogaster</em> and <em>Culex quinquefasciatus</em> Increase Host Resistance to West Nile Virus Infection by Robert L. Glaser (244339)

“…<em>Wolbachia</em>-infected flies had a 500-fold higher ID₅₀ for WNV and produced 100,000-fold lower virus titers compared to flies lacking <em>Wolbachia</em>. …”

Additional <i>Setd5</i> behavioural controls. by Laura E. Burnett (18794525)

“…The top graphic depicts the dimensions and regions of the arena that are classified as the centre (pink, a circular region with a radius of 7 cm from the centre of the arena [X_c,Y_c]), and the edge (blue, the area outside of a circular area with a 14-cm radius from [X_c, Y_c]). …”

Dynamics of the Ca²⁺ depletion waves. by Mitra Esfandiarei (280455)

“…<p><b>A)</b> Heat map generated from the time-lapse fluorescence microscopy movie (10 s intervals) of rat SMCs treated with ET-1 (100 nM) in nominally free extracellular Ca²⁺, showing that the SR depletion wave expands in a near circular fashion in both directions of the scan line (dotted white line). …”

rhMFG-E8 promotes neurological recovery and neural stem cell proliferation after cerebral ischemia. by Cletus Cheyuo (703717)

“…<p>(A) Treatment of rats with rhMFG-E8 significantly decreased neurological deficits at 7 days post-transient middle cerebral artery occlusion (tMCAO) compared with vehicle. …”

Prdm8 alters layer formation in the neocortex. by Mayuko Inoue (516753)

“…Scale bars: 100 µm (A,E).</p>…”

Propagation of the DMI signal into flanking regions in simulated data (sampled at generation 30, significance threshold: <i>X</i>(2)<−0.005 & <i>D</i>’<0). by Juan Li (146180)

“…Two hundred individuals were sampled from each simulation to obtain the statistics. A. The number of significant marker pairs decreases rapidly with distance to the nearest true DMI locus. …”

Knockdown of endogenous GpIbα in cancer cells reduces the frequencies of mitotic and cytokinesis defects, while overexpression of GpIbα in immortalized noncancer cells increases th... by Qian Wu (209382)

“…(B) Frequencies of mitotic and cytokinesis defects in HeLa cells were significantly decreased after GpIbα knockdown and enforced overexpression of a shRNA-resistant GpIbα (mGpIbα) restored most of the mitotic defects (n>100 cells per sample). …”

Data_Sheet_1_Association Between Living Risk and Healthy Life Years Lost Due to Multimorbidity: Observations From the China Health and Retirement Longitudinal Study.docx by Xinlei Miao (11086052)

“…We estimated the healthy life years lost due to multimorbidity using the Sullivan method.…”