Effects of U0126, T0070907, and Pioglitazone hydrochloride (Pio) on NO production in LPS-stimulated RAW264.7 macrophages. by Xiang Li (114679)

“…ENL does-dependently attenuated NO secretion, U0126, T0070907, and Pio further strengthened ENL's effect. 50 µM SDL also showed NO inhibition activity, while U0126 enhanced SDL's effect. * Means compared with model group (200 ng/ml LPS treated alone), and # stands for statistic significance analysis between two groups with and without small molecular tool drugs (<i>i.e.…”

Possible roles of sestrin2 in multiple sclerosis and its relationships with clinical outcomes by Faruk Omer ODABAS (12652740)

“…In the ROC analysis of SESN2, the predictive level for MS was 2.36 ng/mL [sensitivity, 72.50%; specificity, 55.56%; p=0.002; area under the curve (AUC)=0.693]. …”

Table_1_The Immunologic Effect of Early Intravenous Two and Four Gram Bolus Dosing of Tranexamic Acid Compared to Placebo in Patients With Severe Traumatic Bleeding (TAMPITI): A Ra... by Philip C. Spinella (5181788)

“…Background<p> The hemostatic properties of tranexamic acid (TXA) are well described, but the immunological effects of TXA administration after traumatic injury have not been thoroughly examined. We hypothesized TXA would reduce monocyte activation in bleeding trauma patients with severe injury.…”

Image_1_The Impact of Multimorbidity Burden, Frailty Risk Scoring, and 3-Directional Morphological Indices vs. Testing for CSF Responsiveness in Normal Pressure Hydrocephalus.JPEG by Shereen X. Y. Soon (9569062)

The Cost-Effectiveness of Intermittent Preventive Treatment for Malaria in Infants in Sub-Saharan Africa by Lesong Conteh (231114)

DataSheet1_The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells.ZIP by Hai-Ling Gao (9501677)

“…However, MK-2206 (0.3 and 1 μM) significantly increased the anticancer efficacy of mitoxantrone, SN-38 and topotecan, in H460/MX20 and S1-M1-80 cancer cells, as indicated by a significant decrease in their IC50 values, compared to cells incubated with vehicle. …”

Data_Sheet_1_Excess Mortality in Italy During the COVID-19 Pandemic: Assessing the Differences Between the First and the Second Wave, Year 2020.PDF by Maria Dorrucci (252694)

“…During the first wave (25th February−31st May), we estimated 52,437 excess deaths (95% CI: 49,213–55,863) and 50,979 (95% CI: 50,333–51,425) during the second phase (10th October−31st December), corresponding to percentage 34.8% (95% CI: 33.8%–35.8%) in the second wave and 31.0% (95%CI: 27.2%–35.4%) in the first. …”

Results of the Implementation of a Pilot Model for the Bidirectional Screening and Joint Management of Patients with Pulmonary Tuberculosis and Diabetes Mellitus in Mexico by Martín Castellanos-Joya (630597)

Data_Sheet_2_Excess Mortality in Italy During the COVID-19 Pandemic: Assessing the Differences Between the First and the Second Wave, Year 2020.PDF by Maria Dorrucci (252694)

“…During the first wave (25th February−31st May), we estimated 52,437 excess deaths (95% CI: 49,213–55,863) and 50,979 (95% CI: 50,333–51,425) during the second phase (10th October−31st December), corresponding to percentage 34.8% (95% CI: 33.8%–35.8%) in the second wave and 31.0% (95%CI: 27.2%–35.4%) in the first. …”

Characterization of phenotypically unique accessions. by Maria Stefania Przybylska (22756354)

“…<p><b>a)</b> Map of the geographic origin of phenotypically unique accessions, showing those from Sweden (orange) and from Spain (purple). …”

Neurochemical identity of dFB^23E10Ո^84C10 neurons. by Joseph D. Jones (13883524)

“…<b>(K)</b> Box plots of total sleep change in % ((total sleep on activation day-total sleep on baseline day/total sleep on baseline day) × 100) for control (<i>Empty-Split>CsChrimson</i>), <i>VGlut-AD; 84C10-DBD>CsChrimson</i> and <i>84C10-AD; ChAT-DBD>CsChrimson</i> female flies under a 50 Hz optogenetic activation protocol. …”

The Native <em>Wolbachia</em> Endosymbionts of <em>Drosophila melanogaster</em> and <em>Culex quinquefasciatus</em> Increase Host Resistance to West Nile Virus Infection by Robert L. Glaser (244339)

“…<em>Wolbachia</em>-infected flies had a 500-fold higher ID₅₀ for WNV and produced 100,000-fold lower virus titers compared to flies lacking <em>Wolbachia</em>. …”

TRPS1 redistributes ER binding to modulate ER target gene transcription. by Thomas G. Scott (4092892)

“…<p>A: Kinetic traces of activated and repressed ER target genes over the time course. …”

Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations by Zhijun Zhang (315079)

“…Patient-derived neurons were more sensitive than control neurons to 100 nM straurosporine but not to other inducers of cellular stress. …”

Data_Sheet_1_Association Between Living Risk and Healthy Life Years Lost Due to Multimorbidity: Observations From the China Health and Retirement Longitudinal Study.docx by Xinlei Miao (11086052)

“…We estimated the healthy life years lost due to multimorbidity using the Sullivan method.…”

Table_1_Stable carbon isotopes of dissolved inorganic carbon in the Western North Pacific Ocean: Proxy for water mixing and dynamics.pdf by Tiantian Ge (292883)

“…A downward trend was present in the δ¹³C-DIC signature from north to south in the North Pacific Intermediate Water (NPIW) and Pacific Deep Water (PDW) in the western NP, which reflected the remineralization of organic matter with a horizontal transport of NPIW and PDW. We found a strong ¹³C Suess Effect in the upper 2,000 m in the western NP Ocean, and δ¹³C-DIC at the surface (<50 m) has decreased by 0.60‰-0.85‰ since 1993. …”

Data_Sheet_5_Soundscape in Times of Change: Case Study of a City Neighbourhood During the COVID-19 Lockdown.PDF by Sara Lenzi (4768551)

“…The social restrictions imposed through national legislation divided the 69-day period into three phases. We collected observations, field audio recordings, photography, and diary notes on 50 days. …”

Data_Sheet_3_Soundscape in Times of Change: Case Study of a City Neighbourhood During the COVID-19 Lockdown.PDF by Sara Lenzi (4768551)

“…The social restrictions imposed through national legislation divided the 69-day period into three phases. We collected observations, field audio recordings, photography, and diary notes on 50 days. …”

Datasheet3_Genetic association of lipids and lipid-lowering drugs with sepsis: a Mendelian randomization and mediation analysis.docx by Chen Lou (16790187)

“…The indirect impact of ApoA-I explained over 50% of the curative effects of CETP inhibitors in sepsis.…”

Image_5_Linkage analysis and residual heterozygotes derived near isogenic lines reveals a novel protein quantitative trait loci from a Glycine soja accession.TIFF by Yia Yang (13172682)

“…We identified two genomic regions based on recombination events which had significant increases of 0.65 and 0.72% in seed protein content without a significant decrease in seed oil content. …”