Injection of ds<i>TcCPR4</i> prevents severe elytral morphological defects produced by RNAi for <i>TcCPR27</i>. by Mi Young Noh (360269)

“…Elytra from the resulting ds<i>TcCPR27</i>-treated adults were malformed, wrinkled, warped and fenestrated as reported previously [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004963#pgen.1004963.ref008" target="_blank">8</a>], while those from the resulting ds<i>TcCPR4/27</i>-treated adults were less severely affected and expanded well enough to yield a decrease in desiccation-induced mortality produced by <i>TcCPR27</i> RNAi (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004963#pgen.1004963.s007" target="_blank">S7 Fig.…”

<i>apol1</i> morphant zebrafish embryos display generalized edema and glomerular filtration defects indicative of nephropathy. by Blair R. Anderson (765261)

“…(E) Representative eye image series of zebrafish larvae for each injection group show a relatively stable or a decrease in fluorescence intensity over time compared to sham-injected controls. …”

Wnt/β-catenin reduces <i>MKX</i> and <i>TNMD</i> expressions in <i>SCX</i>-programmed tendon progenitors (hMSC-Scx cells). by Yasuzumi Kishimoto (4282138)

“…Relative expressions of <i>AXIN2</i>, <i>MKX</i>, and <i>TNMD</i> in hMSC-Scx cells treated with 50 ng/ml Wnt3a with or without 5 μM IWR <b>(A)</b>, 0 to 2 μM BIO <b>(B)</b>, or 0 to 20 μM IWR <b>(C)</b> are indicated. …”

Inhibitors of the Jak3/STAT5 pathway block GrB expression and cytotoxicity. by Aspen M. Workman (525540)

“…Jak3i at 400 nM and STAT5i at 50 µM show statistically significant decreases in GrB MFI († p = .0006, *p = .0005). …”

Are Environmental Levels of Nonsteroidal Anti-Inflammatory Drugs a Reason for Concern? Chronic Life-Cycle Effects of Naproxen in Zebrafish by Susana Barros (586042)

“…The nonsteroidal anti-inflammatory drug naproxen (NPX) is among the most consumed pharmaceuticals worldwide, being detected in surface waters within the ng to μg/L range. Considering the limited chronic ecotoxicity data available for NPX in aquatic ecosystems, the present study aimed at evaluating its impact in the model organism Danio rerio, following a full life-cycle exposure to environmentally relevant concentrations (0.1 to 5.0 μg/L). …”

DataSheet_1_The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers.pdf by Eline van Diest (14330511)

“…We successfully enhanced the fraction of γδECTO-αCD3-dimers by shortening the linker length between the heavy and light chain in the anti-CD3 scFv, though this also decreased protein yield by 50%. …”

Supplementary Material for: Systematic Review and Meta-Analysis of the Impact of Hypoxia on Infarcted Myocardium: Better or Worse? by Pang B. (5404793)

“…With this systematic review and meta-analysis, we aimed to discover whether systemic hypoxia is beneficial or detrimental to the infarcted myocardium. …”

Diagnosis noma study Anka General Hospital 2021. by Elise Farley (4915459)

“…The epidemiology of noma is not well understood. We aimed to understand the prevalence of all stages of noma in hospitalised children.…”

Fig 2 - by Nathalie Lavenne-Collot (11262998)

“…</p><p></p><p></p><p>- When both sides are at 100%, the light intensity is progressively decreased in 10% steps on the HC’s side, while it remains at 100% on the AN patient’s side.…”

DNA Methylation Is Absent Early During Tumor Development by Rene Opavsky (32415)

“…PCR products for RLGS fragment 3F70 were digested with restriction enzyme BstUI and loaded onto a PAGE gel along with 100% methylated (SssI-treated DNA) control (100%). …”

Modelling results of the study "Doomed descent? How fast sulphate signals diffuse in the EPICA Dome C ice column" by Felix S L Ng (8012813)

“…Inversion for EDC sulphate reveals a rapid decrease in <i>D</i> through the firn layer – from ≈ 10^–6 m² yr^–1 at the surface to ≈ 1.7 ´ 10^–8 m² yr^–1 at the firn-ice transition (≈ 100 m depth, ≈ 2.5 ka), followed by a gradual decline to ≈ 10^–10m² yr^–1 through 100–2700 m (2.5–390 ka). …”

4 EC Performance on Structural Genomics test set. by Eric Venner (235381)

<i>In silico</i> clinical trials suggest little efficacy for corticosteroids or DAMP inhibitors. by Cordelia Ziraldo (221649)

Safety and Efficacy of Ustekinumab and Vedolizumab Among Older Adults with Inflammatory Bowel Disease by Moniyka Sachar (9399032)

Chromosome-level genome assembly of the critically endangered Baer's pochard (Aythya baeri) by Lei Zhang (14491130)

“…The genome has a total length of 1.14 Gb with a scaffold N50 of 85,749,954 bp and a contig N50 of 29,098,202 bp. …”

The effect of shame on anger at others: awareness of the emotion-causing events matters by Ruida Zhu (5439167)

High dose wIFN-α significantly induced intrahepatic expression of T cell, NK cell and IFN-γ response genes. by Simon P. Fletcher (793613)

“…<p>RNA-Seq data for genes selectively induced by high dose (100 μg) but not by low dose (20 μg) wIFN-α. The full list of genes induced by high dose wIFN-α only (n = 468 genes) is displayed in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005103#ppat.1005103.s019" target="_blank">S8C Table</a>.…”

Data Sheet 1_Emotional prompting amplifies disinformation generation in AI large language models.docx by Rasita Vinay (21006911)

“…Introducing polite language to prompt requests yielded significantly higher success rates for disinformation (davinci-002, 79%; davinci-003, 90%; gpt-3.5-turbo, 94%; and gpt-4, 100%). Impolite prompting resulted in a significant decrease in disinformation production across all models (davinci-002, 59%; davinci-003, 44%; and gpt-3.5-turbo, 28%) and a slight reduction for gpt-4 (94%).…”

Selective dynamin 1 inhibition through siRNA impairs both synaptic plasticity and associative memory. by Mauro Fà (59065)

“…<b>D</b>, Bilateral infusions of Penetratin 1- conjugated dynamin 1 siRNA (open triangles) (80 nM in a final volume of 1.5 μl over 1 minute, repeated 2 times a day for three days) into dorsal hippocampi decrease LTP compared to Penetratin 1- conjugated Control siRNA treatment (grey squares) (F_1,9 = 5.578, <i>p</i> = 0.001). …”

Greening Fine Chemical Production via Continuous Flow Technology: An LCA-TEA-SA Integrated Assessment of <i>p</i>‑Nitrobenzoic Acid by Chen Feng (298683)

“…The key findings include the following: (1) CFT outperformed BWT with a 16.91% reduction in 100 year global warming potential, a 13.73% decrease in capital and operating expense, and a 1.5% improvement in overall safety score under real production conditions. (2) A trade-off model identified 154–160 °C as an optimal window where CFT excelled in environment-economy-temperature safety performance. …”