Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer حسب Xingchen Liu (524190)

"…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …"

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer حسب Xingchen Liu (524190)

"…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …"

Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus <i>Penicillium daleae</i> L3SO حسب Qing-Yuan Wang (11571890)

"…Penidaleodiolide A (<b>1</b>) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.…"

ROS and superoxide decrease in the dormant form of mycobacteria. حسب Amar Yeware (7115063)

Tax expression is associated with decreased cellular motility. حسب Saumya Ramanayake (7879091)

Cigarette smoke decreases clathrin mediated endocytosis. حسب Parker F. Duffney (8878145)

HFD decreases nephrocyte uptake of dextran and albumin. حسب Aleksandra Lubojemska (10746241)

Diabetic kidney shows decreased klotho expression. حسب Jeong Suk Kang (7359572)

"…Boxes are enlarged images of representative klotho expression in podocytes and tubules. magnification 40x; scale bar = 50 μm. (b) Verification of klotho expression in immortalized mouse and human podocytes compared to human tubule cells by Western blot. …"

The decrease in blood flow disrupts CV pruning. حسب Lin Wen (557398)

Follicle stem cell proliferation was severely reduced when Wg was tethered to the plasma membrane. حسب Xiaoxi Wang (130742)

Viral inhibition assay in combination of VPA with or without fixed dose (25 μM)of both DHA and LA. حسب Amanda Watson (4447267)

Transforming Small-Molecule Nanoaggregation into Functional Drug Delivery Platforms حسب JunHyuk Kim (21235657)

"…The IC₅₀ value of <b>Nano-CC1-Acl</b> further decreases to 0.20 ± 0.16 μM in the presence of cysteine, a biothiol. …"

Transforming Small-Molecule Nanoaggregation into Functional Drug Delivery Platforms حسب JunHyuk Kim (21235657)

"…The IC₅₀ value of <b>Nano-CC1-Acl</b> further decreases to 0.20 ± 0.16 μM in the presence of cysteine, a biothiol. …"

3‑Hydroxypyridin-4(1<i>H</i>)‑one Derivatives as <i>pqs</i> Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in <i>Pseudomonas aeruginosa</i> حسب Zhi-Ying Miao (9388615)

"…The most potent derivative <b>16e</b> was identified as a selective inhibitor of the <i>pqs</i> system (IC₅₀ = 3.7 μM) and its related virulence factor pyocyanin (IC₅₀ = 2.7 μM). …"

Fig 4 - حسب Martina Mušković (16834146)

"…The singlet oxygen production was evaluated as the decrease (%) of fluorescence intensity of 1,3-diphenylisobenzofuran (DPBF) (4 μM) at <i>λ</i> = 453 nm in 50% EtOH and 50% DEMI water (A) or municipal wastewater (B) solution with porphyrin TMPyP3 (1 μM). …"

MCF-7 cells were treated with 0, 10, or 20 μM of Peptide 1 or Peptide 2 for 48h. حسب Deepu Dowarha (5673440)

The MCF-7 and/or MDA-MB-468 cells were treated with or without 10 μM Peptide 1 for 48h. حسب Deepu Dowarha (5673440)

Effects of betaine on diuresis [μl/min/g k.w.], HR [bpm] and MABP [mmHg] in anesthetized Spontaneously Hypertensive rats and Wistar Kyoto normotensive rats. حسب Izabella Mogilnicka (13965422)

Synthesis and Biological Evaluation of C‑17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment حسب Jie Wang (16762)

الموضوعات:

Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc... حسب Mary A. Foutz (20361830)

الموضوعات: