First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

HE images of the adherent cells in the 2D and 3D scaffold systems. by Lucrezia Ferretti (18806152)

“…Cells within SHE (5x magnification) reach 60% confluence at 24h (p) and a 100% confluence at 72h (q). Instead, in SHR1 (5x magnification), SHR2 and SHR3 (10x magnification) the cells barely reached 50% confluence at 72h, then the cellularity decreased between 72h and 7 days (j-o). 2D culture (5x magnification) show a higher cellularity in each time point compared to scaffolds (a-c). …”

Association between AIP and depression in total people by Siyi Deng (12887198)

Losartan is not neuroprotective in a crush model of axon injury. by Harry A. Quigley (695817)

Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial by Michel Mandro (2637532)

“…The primary endpoint was defined as the probability of being seizure-free at month 4. A secondary endpoint was defined as >50% reduction in seizure frequency at month 4, compared to baseline. …”

Gas exchange model used to construct oxygen-haemoglobin dissociation curves (ODC) for the cohort. by Nikhil Mayor (13989363)

Image_3_In Kluyveromyces lactis a Pair of Paralogous Isozymes Catalyze the First Committed Step of Leucine Biosynthesis in Either the Mitochondria or the Cytosol.PDF by Beatriz Aguirre-López (5214167)

Table_1_In Kluyveromyces lactis a Pair of Paralogous Isozymes Catalyze the First Committed Step of Leucine Biosynthesis in Either the Mitochondria or the Cytosol.DOCX by Beatriz Aguirre-López (5214167)

Image_1_In Kluyveromyces lactis a Pair of Paralogous Isozymes Catalyze the First Committed Step of Leucine Biosynthesis in Either the Mitochondria or the Cytosol.PDF by Beatriz Aguirre-López (5214167)

Expression of proline metabolism enzymes in a mouse model of CRC. by Saif Sattar Alaqbi (12055053)

“…The scatter blots represent the ΔCT values in <i>Apc</i> deleted (<i>Apc-/-</i>) mice and <i>Apc</i> WT (<i>Apc+/+)</i> controls. Hence, a decrease in ΔCT is equivalent to an increase in gene expression. …”

Depletion of <i>cyd-1</i> leads to decreased oocyte quality and increased apoptosis without affecting the DNA damage response (DDR). by Umanshi Rautela (20235283)

Strains carrying different <i>ELP3</i> mutant alleles show decreased telomeric gene silencing and increased HU sensitivity. by Changchun Chen (139128)

Image1_Association between mental health and male fertility: depression, rather than anxiety, is linked to decreased semen quality.tif by Yi Zhang (9093)

“…Background<p>Infertility is increasingly recognized as a global health issue affecting couples of reproductive age, with male factors contributing to approximately 50% of infertility cases. …”

Proline metabolism in PF <i>T</i>. <i>brucei</i> and reactions catalysed by potential B-THP-T targets. by Lindsay B. Tulloch (1266861)

Significantly decreased levels of CD4⁺CD25⁺ Treg cells in arthropathic Tax transgenic mice. by Takeo Ohsugi (225723)

“…(B) The majority of CD4⁺CD25⁺ T cells in non-transgenic mice expressed a high level of Foxp3 (81.2±1.4%), whereas half of CD4⁺CD25⁺ T cells in arthropathic Tax transgenic mice did not express Foxp3 (50.2±5.2%) (n = 6 per group), *** <i>P</i><0.001. …”

DataSheet1_Solamargine Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma by Decreasing LncRNA HOXA11-As Expression.PDF by Ying Meng (327793)

Decreased accumulation of inflammatory cells in SOCS1^−/−IFN-γ^−/− mice at the resolution phase of influenza infection. by Keer Sun (673151)

Gating strategy of experiment using 30 min EdU pulses experiments in mOr2-Piwi1 juvenile polyps. by Eudald Pascual-Carreras (12115380)

<i>PB-Cre4; SypELDTA</i> line 147 mice show decreased number of NE cells and prostate hypotrophy. by Chieh-Yang Cheng (405156)