Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

Validation of NUMB as a target for <i>miR-146a</i>. by Pei-Shi Hung (489732)

Image_1_Extracellular Vesicles Carry lncRNA SNHG16 to Promote Metastasis of Breast Cancer Cells via the miR-892b/PPAPDC1A Axis.TIFF by Wenfei Xia (5055482)

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

High blood glucose levels in rats after exposure to STZ. by Shatw Khalid Ali (13020885)

Potent 5‑Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction by Wenjuan Zhou (115285)

“…After finding a novel inhibitor <b>DC-1</b> with IC₅₀ = 1.2 μM, we performed a series of chemical optimizations, which finally led to the discovery of a potent thiazole containing 5-cyano-6-phenylpyrimidin-based inhibitor <b>DC-2</b> (IC₅₀ = 15 nM). …”

Image analysis of pretargeted bone uptake of tetrazines 1a-4a. by Lennart Bohrmann (14803846)

“…<p>(A-C) Organ activity in selected organs over the course of the study. …”

The effects of metformin, donepezil, insulin glargine, and glibenclamide on brain biomarkers: Amyloid β 42, nitric oxide, acetylcholinesterase, malondialdehyde, β secretase, and pM... by Shatw Khalid Ali (13020885)

Absence of hUCB-MSCs in the Parenchyma in Mice Sacrificed After 6 Hours. by Na Kyung Lee (251487)

PolyP levels stabilize the Ft-MglA and Ft-SspA interaction in a bacterial two-hybrid system. by Algevis P. Wrench (276279)

“…<p>Transcription activation by the interaction between MglA and SspA fusion proteins from <i>F. tularensis</i> SCHU S4 decreases in the absence of polyP. β-galactosidase activity levels from AW23 cells (square), AW24 (circle), and AW26 (triangle). …”

A trial of seven footfalls in which the subject (emu) underwent a gradual deceleration. by P. J. Bishop (4219759)

Activity of miR-124 and miR-23a in NSC-derived neurons and astrocytes. by Annalisa Lattanzi (427545)

“…(B–E) A significant decrease of GFP expression is observed in bdLV.miRT124-transduced neurons (βtubIII, MAP2) (<b>B, C</b>) and in bdLV.miRT23a-transduced astrocytes (GFAP) and immature glial cells (nestin) (<b>D, E</b>). …”

The effect of glibenclamide on channel activity at +20, 0 and -20 mV. by Sajjad Salari (736104)

“…Histogram bars show current amplitudes and P_o of reconstituted channels in absence or presence of glibenclamide. The addition of 50 μM glibenclamide resulted in a decreased current jump amplitude and a reduction in P_o. 100 μM glibenclamide caused a total channel inhibition at +20 and 0 mV (n = 5), but was ineffective at -20 mV. …”

Replication Data for: Diversion of flow and sediment towards a side channel separated from a river by a longitudinal training dam by T.V. (Timo) de Ruijsscher (9147971)

“…The angle between the main river flow and the flow into the side channel increases with decreasing lateral and longitudinal distance to the bifurcation point, which corresponds to the head of the training dam. …”

SarA activates <i>fmtA</i> transcription <i>in vitro</i>. by Yinglu Zhao (309307)

“…The substitution of T1G in the proposed transcription start point of the <i>fmtA</i> promoter led to a significant decrease in the transcript (*p = 0.0242) whereas the mutation of the T14 to G in P_fmtAT14G has the most pronounced effect on the transcription (**p = 0.001). …”

Relationship between abundance of Woody Plants, Animal and Plant Species by Geethanjanen Raveendhran (3113937)

“…</p> <p> </p> <p>9) Abundance vertebrates: This is a discrete variable, which was measured with the use of a point/observation survey while standing at the beginning of the 50m transect.  …”

Macroeconomic burden of NMHs for the whole South American region over the period 2020–2050 across various scenarios. by Maddalena Ferranna (9969446)

“…<i>Larger treatment cost impact scenario</i> = treatment costs reduce physical capital investments by a proportion 50% greater than the saving rate; all other assumptions as in the baseline scenario. …”