SC-1 Inhibited RSK2 Kinase Activity <i>in vitro</i> and an RSK2 Inhibitor Increased Colony Formation. by Susan D. Mertins (380936)

“…<p>COLO 205 tumor cell line was treated with SL0101 (1.25 µM) and SC-1 (0.1 µM) for 24 hrs prior to soft agar cloning, lysate preparation, and immunoblotting. A. SC-1 inhibited RSK2 N-terminal domain <i>in vitro</i> kinase activity with an EC₅₀ of 2.5±1.8 µM (mean±SD, n = 5) but not in other like assays for Aurora kinase B, CHK1, or CHK2 kinases. …”

SS inhibits breast cancer growth <i>in vivo</i>. by Zhiyu Wang (282312)

“…The results indicated that LDH-A expression in both SS-treated breast cancer xenografts were significantly reduced, while TUNEL analysis indicated that the apoptosis ratio in SS –treated tumor samples was significantly increased. (×100, scale bar = 50 um; All values represents as Mean±SD, n = 6, *<i>P</i><0.05 <i>vs.…”

Effects of FXR ligand on epithelial-mesenchymal transition and fibrosis in cisplatin-induced kidney injury. by Eun Hui Bae (413566)

“…(B) <i>In vitro</i> (HK-2 cells) studies showed that FXR ligand pretreatment (20 µM, 1h) also reduced fibronectin and connective tissue growth factor (CTGF) expression induced by cisplatin (50 µM, 16 h). Each column represents mean ± SEM. …”

Data Sheet 2_Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements.pdf by Pascal Syren (20762843)

“…In this study, APD₉₀, APD₅₀ and APD₃₀, are decreased at more negative RMP (respectively HMP) values. …”

Data Sheet 1_Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements.docx by Pascal Syren (20762843)

“…In this study, APD₉₀, APD₅₀ and APD₃₀, are decreased at more negative RMP (respectively HMP) values. …”

Deficiency of tau protects against age-dependent neurodegeneration and memory loss measured by deficits in spontaneous alternations in AICD-Tg mice. by Kaushik Ghosal (244754)

“…<p>A. AICD-Tg mice exhibit decreased working memory as measured by deficits in spontaneous alternations at older ages. …”

Achieving Long-Acting Local Analgesia Using an Intelligent Hydrogel Encapsulated with Drug and pH Regulator by Wen Guo (112664)

“…Considering the decrease of solubility of BUP with the increase of pH and the internal acidic environment due to the hydrolysis of PLGA, calcium carbonate (CaCO₃) powder was introduced as a pH regulator. …”

<i>Krt76^mutant</i> mice show barrier function defects and KRT76 stabilises Claudin1 at tight junctions. by Tia DiTommaso (648579)

“…(D) Immunofluorescence analysis of CLDN1 and Ecadherin (ECAD) distribution in wild type and <i>Krt76^tm1a/tm1a</i> mouse dorsal skin. (E) Image quantification at the cellular surface shows an inward shift and a decrease in intensity of CLDN1 not observed with ECAD. …”

AgDscam Is Implicated in Anti-Bacterial Defense by Yuemei Dong (17509)

“…<div><p>(A) RNAi-mediated depletion of AgDscam with a <i>dsRNA</i> fragment complementary to a non-spliced <i>AgDscam</i> exon resulted in decreased mosquito survival after challenge with S. aureus and E. coli compared to the challenged control <i>GFP dsRNA</i>-treated (GFP) mosquitoes. …”

Reaching the Unreachable: Providing STI Control Services to Female Sex Workers via Mobile Team Outreach by Pablo E. Campos (302579)

“…<div><p>Background</p><p>As part of a community-randomized trial of a multicomponent intervention to prevent sexually transmitted infections, we created Mobile Teams (MTs) in ten intervention cities across Peru to improve outreach to female sex workers (FSW) for strengthened STI prevention services. …”

Table 1_Analysis of the threshold range of ROS concentration in winter rapeseed of the Brassica napus type.docx by Weiliang Qi (9389353)

“…At half-lethal H₂O₂ concentrations (1.4%–1.5%), the seed germination rate before rehydration is significantly reduced to 10.97% and 9.03%, respectively, but can recover to approximately 50% after rehydration. H₂O₂ concentrations exceeding 2.2% are lethal, resulting in a 0% seed germination rate both before and after rehydration; notably, the post-rehydration germination rate remains below 10%. …”

Image_6_Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells.tif by Patrick M. McTernan (341264)

“…These results suggest that ethanol impairs CD4⁺ T cell immunometabolism and disrupts mitochondrial repair processes as it promotes CD4⁺ T cell differentiation to a pro-inflammatory phenotype.</p>…”

Data_Sheet_1_Conditioned Medium of Human Menstrual Blood-Derived Endometrial Stem Cells Protects Against MPP+-Induced Cytotoxicity in vitro.docx by Han Li (10885)

“…Our study provided the first evidence that MenSCs-CM has a protective effect on MPP⁺-induced cytotoxicity in various aspects, and firstly showed that MenSCs can release at least 12 kinds of neurotrophic factors to medium, which may contribute to the protective function of MenSCs-CM to treat PD. …”

Image_4_Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells.tif by Patrick M. McTernan (341264)

“…These results suggest that ethanol impairs CD4⁺ T cell immunometabolism and disrupts mitochondrial repair processes as it promotes CD4⁺ T cell differentiation to a pro-inflammatory phenotype.</p>…”

The association between observed mobility and quality of life in the near elderly by Jason Shafrin (4379500)

“…This cross-sectional study aimed to assess the association between mobility and quality of life measures in the near elderly.</p><p>Methods</p><p>A prospective observational study of persons aged 50–69 years was conducted. …”

Supplementary Material for: Depressive Symptoms, Subjective Cognitive Decline, and Subjective Sleep Quality Are Associated with Slips and Falls: Data from the Community Health Surv... by Kim J.H. (2867312)

“…<b><i>Results:</i></b> The risk of slips/falls was significantly associated with high levels of depressive symptoms (adjusted OR 1.06, 95% CI: 1.05–1.07) and SCD (adjusted OR 1.33, 95% CI: 1.19–1.50). Regarding each sleep quality component, the adjusted ORs for slips/falls were 1.85 for very poor sleep quality, 1.49 for long sleep latency, 1.04 for <5 h of sleep duration, 1.32 for low sleep efficiency, 2.78 for high sleep disturbance, 1.52 for the use of sleep medication ≥3 times a week, and 1.82 for high daytime dysfunction due to sleep problems compared to the respective good sleep conditions. …”

Restructuring the Crystalline Cellulose Hydrogen Bond Network Enhances Its Depolymerization Rate by Shishir P. S. Chundawat (2163151)

“…Ammonia transformed the naturally occurring crystalline allomorph I_β to III_I, which led to a decrease in the number of cellulose intrasheet hydrogen bonds and an increase in the number of intersheet hydrogen bonds. …”

DataSheet_1_Assessment of export-embodied CO2 emissions from China’s ocean industries: implications for formulating sustainable ocean policies.docx by Li Zheng (15952)

“…Regarding the evolution from 2007 to 2017, the total export-embodied CO₂ emissions from ocean industries decreased by 7.3%, while the embodied CO₂ emissions in processing ocean exports increased by 50.1%. …”

Restructuring the Crystalline Cellulose Hydrogen Bond Network Enhances Its Depolymerization Rate by Shishir P. S. Chundawat (2163151)

“…Ammonia transformed the naturally occurring crystalline allomorph I_β to III_I, which led to a decrease in the number of cellulose intrasheet hydrogen bonds and an increase in the number of intersheet hydrogen bonds. …”

Attention Deficit/Hyperactivity Disorder Symptoms and Cognitive Abilities in the Late-Life Cohort of the PATH through Life Study by Debjani Das (333500)

“…ADHD, mood disorder symptoms and cognitive abilities were assessed in a large population-based sample (n = 3443; 50% male). …”