Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria by Al-Sadeq, Duaa W.

“…Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). …”
Get full text
Get full text
Get full text

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease by Nisha Rathore (5924609)

“…The G78R variant alters the interaction of residues essential for sialic acid engagement, resulting in >50% reduced binding for several PILRA ligands including a novel ligand, complement component 4A, and herpes simplex virus 1 (HSV-1) glycoprotein B. …”

Chromosomal microdeletions contribute to mitochondrial respiratory chain complex deficiencies. by Masakazu Kohda (206767)

“…The <i>COX10</i> expression in Pt369 and Pt657 was decreased by 50%. (<b>E</b>–<b>G</b>) Wild type <i>COX10</i> cDNA rescue of complex IV assembly and activity in Pt657 fibroblasts. …”

Optogenetic closed-loop experiments with MARGO. by Zach Werkhoven (6473165)

“…Even at the lowest intensity (50%), flies show a robust avoidance of the reinforced arm in a Y-Maze. …”

Image_2_Antidiabetic, Antihyperlipidemic, Antioxidant, Anti-inflammatory Activities of Ethanolic Seed Extract of Annona reticulata L. in Streptozotocin Induced Diabetic Rats.JPEG by Wenbin Wen (7528595)

“…Furthermore, A. reticulata significantly decreased the levels of triglycerides, cholesterol, LDL, and significantly increased the HDL in diabetic rats. …”

Image_3_Antidiabetic, Antihyperlipidemic, Antioxidant, Anti-inflammatory Activities of Ethanolic Seed Extract of Annona reticulata L. in Streptozotocin Induced Diabetic Rats.JPEG by Wenbin Wen (7528595)

“…Furthermore, A. reticulata significantly decreased the levels of triglycerides, cholesterol, LDL, and significantly increased the HDL in diabetic rats. …”

Image_4_Antidiabetic, Antihyperlipidemic, Antioxidant, Anti-inflammatory Activities of Ethanolic Seed Extract of Annona reticulata L. in Streptozotocin Induced Diabetic Rats.JPEG by Wenbin Wen (7528595)

“…Furthermore, A. reticulata significantly decreased the levels of triglycerides, cholesterol, LDL, and significantly increased the HDL in diabetic rats. …”

Image_1_Antidiabetic, Antihyperlipidemic, Antioxidant, Anti-inflammatory Activities of Ethanolic Seed Extract of Annona reticulata L. in Streptozotocin Induced Diabetic Rats.TIF by Wenbin Wen (7528595)

“…Furthermore, A. reticulata significantly decreased the levels of triglycerides, cholesterol, LDL, and significantly increased the HDL in diabetic rats. …”

Schematic representation of possible mechanism of gene regulation by <i>Leishmania donovani</i> HAT2. by Udita Chandra (4455454)

“…Lower panel: In HAT2-depleted cells H4K10 acetylation decreases by ~ 50% at both, dSSRs and at cell cycle-distinctive promoters. …”

Data_Sheet_2_Lycium barbarum Polysaccharides as Antibiotic Substitutes Improve Growth Performance, Serum Immunity, Antioxidant Status, and Intestinal Health for Weaned Piglets.docx by Yexin Yin (11289135)

“…Dietary LBPs enhanced the activity of serum total antioxidant capacity and glutathione peroxidase, and decreased malondialdehyde levels (P < 0.05). Principal component analysis showed a distinct separation between CON and LBPs groups, but no differences between ABO and LBPs groups. …”

Data_Sheet_1_Lycium barbarum Polysaccharides as Antibiotic Substitutes Improve Growth Performance, Serum Immunity, Antioxidant Status, and Intestinal Health for Weaned Piglets.PDF by Yexin Yin (11289135)

“…Dietary LBPs enhanced the activity of serum total antioxidant capacity and glutathione peroxidase, and decreased malondialdehyde levels (P < 0.05). Principal component analysis showed a distinct separation between CON and LBPs groups, but no differences between ABO and LBPs groups. …”

Effects of heterozygosity for <i>Clcc1</i> KO on mouse retinas. by Lin Li (28817)

“…(i-l) Electroretinography of WT and <i>Clcc1</i> knockout heterozygous mice show approximately 20–50% decreases in the amplitude of both the scotopic and photopic a and b wave amplitude responses in <i>Clcc1</i> KO heterozygous mice compared to WT at all levels of luminance.…”

Species persistence collapses for high rates of environmental change within environmental ranges that are otherwise presumed safe. by Sjoerd Terpstra (17763202)

“…<b>(B)</b> The persistence of species decreases as a function of the maximum value of the driver of decline, represented as a fraction <i>θ</i> of the point of collapse, for a fast rate of change (λ = 1). …”

Genes identified in Esp1-13Myc mass spectrometry screen implicated in Ty1 transposition. by Krystina L. Ho (714635)

“…<p>^aAll mutants have decreased Ty1 transposition except for <i>YML105C</i> and <i>YOL159C</i> [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005109#pgen.1005109.ref040" target="_blank">40</a>]</p><p>^bMutants that suppress the hypertransposition phenotype of <i>rtt101Δ</i> and <i>med1Δ</i> mutants [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005109#pgen.1005109.ref045" target="_blank">45</a>]</p><p>^c<i>rtt</i> mutants have increased levels of Ty1 transposition [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005109#pgen.1005109.ref043" target="_blank">43</a>]</p><p>^d<i>SPT16</i> is a high-copy suppressor of Ty1-δ insertion mutations [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005109#pgen.1005109.ref050" target="_blank">50</a>,<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005109#pgen.1005109.ref051" target="_blank">51</a>]</p><p>^e<i>spt</i> mutants suppress <i>his4-912δ</i> Ty insertion mutations [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005109#pgen.1005109.ref052" target="_blank">52</a>]</p><p>Genes identified in Esp1-13Myc mass spectrometry screen implicated in Ty1 transposition.…”

Axon misguidance phenotypes in vivo occur where the Shh gradient is shallow. by Tyler F. W. Sloan (715369)

“…<b>(B)</b> Shh concentration was highest at the floor plate and decreased rapidly in the first ~50 μm (relative distance of 0–0.1) from the floor plate. …”

Conduction velocity and stimulus dynamics constrain meaningful population sizes of LIF model neurons. by Tim C. Hladnik (16819663)

“…<b>A</b>: Conduction velocity of 7 <i>ms</i>⁻¹, as described for some visual fibers in the monkey corpus callosum [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1010871#pcbi.1010871.ref055" target="_blank">55</a>]<b>B</b>: 25 <i>ms</i>⁻¹ for example measured in squid giant axons [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1010871#pcbi.1010871.ref018" target="_blank">18</a>], <b>C</b>: 50 <i>ms</i>⁻¹ as estimated above for P-unit afferents.…”

Impact of Irrational Use of Antibiotics Among Patients in the Intensive Care Unit on Clinical Outcomes in Sudan by Abdelkarim, Omalhassan Amir

Get full text
Get full text
Get full text

Expression of <i>Fgf8</i> in the AER following Dox-IP. by Soula Danopoulos (346564)

“…B,D,F are high magnification of A,C,E. (C,D) <i>Fgf8-AER</i> expression is decreased at 1 hour after Dox-IP injection. …”

Table 1_Slavs in the closet: computational genomic analysis reveals cryptic slavic signatures in the Avar Khaganate and their contribution to medieval Croatian population formation... by Todor Chobanov (22288636)

“…Using a quality-controlled dataset of 1,800 ancient DNA samples, we implemented a comprehensive analytical framework centered on systematic screening of marginal Principal Components to detect cryptic Slavic genetic signatures. …”

Optimizing Irradiation Dose for <i>Drosophila melanogaster</i> Males to Enhance Heterospecific Sterile Insect Technique Against <i>Drosophila suzukii</i> by Flavia Cerasti (21075827)

“…However, longevity decreased with increasing doses, with males irradiated at 160–180 Gy showing a lifespan reduction of up to 50 days compared to controls. …”