The phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies by Kerrie Faia (2409427)

“…Single agent activity was seen in fourteen cell lines, with a median GI₅₀ of 0.59 μM. A scalar measure of the strength of synergistic drug interactions revealed a synergy hit rate of 19.3% across the matrix of drug combinations and cell lines. …”

Supplementary file 1_Past and future trends in swiss snow cover: multi-decades analysis using the snow observation from space algorithm.docx by Charlotte Poussin (20718146)

“…The pixel-wise analysis reveals significant negative trends in the monthly NDSI across all seasons, with the most pronounced decreases at low to mid-elevations, particularly in winter and spring (e.g., a 50% reduction in NDSI for pixels showing positive significative trends in winter below 1,000 m, and a 43% reduction in spring between 1,000 and 2,000 m). …”

Influence of alumina air-abrasion for highly translucent partially stabilized zirconia on flexural strength, surface properties, and bond strength of resin cement by Keiichi YOSHIDA (8438556)

“…Conclusion Micromechanical retention by alumina air-abrasion at 0.2 MPa, in combination with chemical bonding of a resin to highly translucent Y-PSZ using a MDP-containing resin cement may enable durable bonding.…”

Data_Sheet_1_Drug Repositioning for P-Glycoprotein Mediated Co-Expression Networks in Colorectal Cancer.xlsx by Hande Beklen (9236813)

“…Drug repositioning is the approach for using existing drugs for a new therapeutic purpose; it is a highly efficient and low-cost process. …”

Table 1_The 15-year trend in adherence to dietary recommendations and ultra-processed food consumption in Italy.docx by Jacopo Niccolò Di Veroli (18857410)

“…AIDGI and WISH2.0 showed scores close to 50% of the theoretical maximum achievable indicating that there is substantial room for improvement in the Italian dietary quality. …”

Data_Sheet_1_Shared Microbial Taxa Respond Predictably to Cyclic Time-Varying Oxygen Limitation in Two Disparate Soils.pdf by Steven J. Hall (1414792)

“…However, the OTUs present in both soils were disproportionally abundant, comprising 50% of sequences, and they often had a similar response to anoxic period duration in both soils (p < 0.0001). …”

Development of standard clinical endpoints for use in dengue interventional trials by Kay M. Tomashek (170450)

“…Notably, 68% of participants agreed that a 50,000 to 20,000 mm³ platelet range be used to define moderate thrombocytopenia; however, they remained divided on whether a rapid decreasing trend or one platelet count should be case defining. …”

Mood Disorders and Risk of Lung Cancer in the EAGLE Case-Control Study and in the U.S. Veterans Affairs Inpatient Cohort by David E. Capo-Ramos (145027)

“…In the VA study, we estimated lung cancer relative risks (RRs) and 95% CIs with time-dependent Poisson regression, adjusting for attained age, calendar year, hospital visits, time within the study, and related previous medical diagnoses. In EAGLE, we found decreased lung cancer risk in subjects with a personal history of mood disorders (OR: 0.59, 95% CI: 0.44–0.79, based on 121 lung cancer incident cases and 192 controls) and family history of mood disorders (OR: 0.62, 95% CI: 0.50–0.77, based on 223 lung cancer cases and 345 controls). …”

Modern High-Yielding Maize, Wheat and Soybean Cultivars in Response to Gypsum and Lime Application on No-Till Oxisol by Douglas Dalla Nora (4655347)

“…Continuous no-tillage management (NTS) frequently leads to a steep gradient in soil chemical quality with depth, thus decreasing yield under conditions of acid subsoil and water stress. …”

Participant flow chart. by Amy M. Thomson (18778772)

“…Changes in fat mass (<i>r</i> = 0.54, <i>p</i> = 0.02), and body fat percentage (<i>r</i> = 0.50, <i>p</i> = 0.02) were significantly associated with the change in HbA1c in those with a long-duration T2DM only.…”

Baseline characteristics of the participants. by Amy M. Thomson (18778772)

“…Changes in fat mass (<i>r</i> = 0.54, <i>p</i> = 0.02), and body fat percentage (<i>r</i> = 0.50, <i>p</i> = 0.02) were significantly associated with the change in HbA1c in those with a long-duration T2DM only.…”

Image 2_Effects of systemic oxytocin and beta‐3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet‐induced obese rats.jpg by Jared D. Slattery (11405804)

Reconsideration of the Effects of Age on Proximal Femur Structure: Implications for Joint Replacement and Hip Fracture by B. C. C. Khoo (3239391)

“…</p><p>Results</p><p>Over the adult life span total integral volumes at the FN, TR and IT sites expand linearly by between 18 and 37% at the same time as bone mass decreased by 22 to 25% resulting in massive reductions in true volumetric BMD (vBMD) of 40 to 50%. …”

Image 3_Effects of systemic oxytocin and beta‐3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet‐induced obese rats.jpg by Jared D. Slattery (11405804)

Mitochondrial Phenotypes Altered by the HD Mutation or 3-NP Treatment by Jong-Min Lee (105338)

“…<div><p>(A) Mitochondrial membrane potential, denoted by the FL1/FL2 ratio, was significantly decreased by the HD mutation in ST<i>Hdh^Q111/Q111</i> cells (ST111/111), compared to wild-type ST<i>Hdh^Q7/Q7</i> cells (ST7/7).…”

Image 1_Effects of systemic oxytocin and beta‐3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet‐induced obese rats.jpg by Jared D. Slattery (11405804)

Global, regional and national burden of non-Hodgkin lymphoma from 1990 to 2017: estimates from global burden of disease study in 2017 by Haifeng Sun (816300)

“…EAPCs in the incidence of NHL decreased in the low SDI regions but increased in the high SDI regions. …”

Table_1_Altered Variability and Concordance of Dynamic Resting-State fMRI Indices in Patients With Attention Deficit Hyperactivity Disorder.docx by Feiling Lou (11439274)

“…<p>Objective: Attention deficit hyperactivity disorder (ADHD) is a commonly diagnosed neuropsychiatric disorder in children, which is characterized by inattention, hyperactivity and impulsivity. …”

Evidence for clonal hematopoiesis. by Jacob Rinaldi (8807144)

“…The read fraction for <i>DNMT3A</i> decreases with patient age, consistent with CHIP. …”

IIS balances anti-proliferating (tumor-suppressive) and pro-proliferating (oncogenic) activities across tissue boundaries. by Wenjing Qi (142213)

“…Both DAF-16 and SMA-2/3 have individual roles and regulate transcription of distinct target genes [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006801#pgen.1006801.ref019" target="_blank">19</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006801#pgen.1006801.ref042" target="_blank">42</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006801#pgen.1006801.ref050" target="_blank">50</a>]. …”