Image_5_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Table_1_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.docx by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Table_2_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.docx by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Image_2_Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells.TIF by Yating Chen (6707360)

“…Application of Allicin 30 μM reduced the late sodium current (I_Na,L) of the Nav1.5 channel current encoded by ΔKPQ-SCN5A from 1.92 ± 0.12 to 0.65 ± 0.03 pA/pF (P < 0.01, n = 15), which resulted in the decrease of I_Na,L/I_Na,P (from 0.94% ± 0.04% to 0.32% ± 0.02%). …”

Image_8_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Table_1_Major Contribution of Somatostatin-Expressing Interneurons and Cannabinoid Receptors to Increased GABA Synaptic Activity in the Striatum of Huntington’s Disease Mice.docx by Sandra M. Holley (6695477)

“…Patch clamp recordings in voltage-clamp mode were performed on SPNs from brain slices of presymptomatic (2 months) and symptomatic (8 and 12 months) Q175 mice and wildtype (WT) littermates. …”

Image_2_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Image_3_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Toward Computationally Designed Self-Reporting Biosensors Using Leave-One-Out Green Fluorescent Protein by Yao-ming Huang (1512265)

“…LOO7-GFP derived from the wild-type sequence (LOO7-WT) folds and reconstitutes fluorescence upon addition of β-strand 7 (S7) as an exogenous peptide. …”

Image_1_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Table_3_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.docx by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

DataSheet_1_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.docx by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Image_3_Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells.TIF by Yating Chen (6707360)

“…Application of Allicin 30 μM reduced the late sodium current (I_Na,L) of the Nav1.5 channel current encoded by ΔKPQ-SCN5A from 1.92 ± 0.12 to 0.65 ± 0.03 pA/pF (P < 0.01, n = 15), which resulted in the decrease of I_Na,L/I_Na,P (from 0.94% ± 0.04% to 0.32% ± 0.02%). …”

Image_7_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Table_4_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.docx by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Video_3_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.mov by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Effects of different production rates, penetrances and administration times of A3G^ΔVif on HIV growth curve. by Iraj Hosseini (184245)

“…<p>In all the simulations, 500,000 cells were inoculated by 1 ng 24 WT HIV input. (A–D) A3G^ΔVif with different production rates were administered right after inoculation. …”

mRNA Secondary Structures Can Explain Experimental Observations by Michael Hiller (11282)

“…<div><p>(A) A structural change explains exon skipping by the 25G->A mutation in the human <i>CFTR</i> exon 12<b>.</b> NI scores [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0030204#pgen-0030204-b036" target="_blank">36</a>] for the wild-type (wt) and the 25G->A mutation (highlighted gray) indicate the strength of ESE (blue, positive score) and ESS (red, negative score) motifs. …”

Image_6_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”

Image_4_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…The inflammatory and cholesterol-depleting effects of CD were first investigated in low-density lipoprotein receptor knockout (Ldlr^-/) mice that were transplanted with Npc1^nih or Npc1^wt bone marrow and were fed either regular chow or a high-fat, high-cholesterol (HFC) diet for 12 weeks, thereby creating an extreme model of lysosomal cholesterol-induced metabolic inflammation. …”