Image_5_ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization.JPEG by Samuel Peña-Díaz (8131068)

“…ZPD-2 inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro at substoichiometric compound:protein ratios. …”

Stress responses after knockdown of octopamine receptor OAMB and serotonin receptor 5-HT_1A in IPCs. by Jiangnan Luo (218899)

“…In an earlier study it was shown that 5-HT_1A knockdown decreased starvation resistance <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0099732#pone.0099732-Luo1" target="_blank">[22]</a>. …”

Image 1_Age-dependent diminution of female prognostic advantage in gastrointestinal stromal tumors: a retrospective cohort analysis.pdf by Yue Zhang (30585)

“…Moreover, a significant interaction between age and sex was observed in predicting DSS, notably indicating that younger female subjects (≤50 years) demonstrated a more favorable prognosis relative to their male counterparts.…”

<i>par2b</i> is partially required downstream of <i>ap1b1a</i> for aggregate formation and increased <i>mmp9</i> expression in the epidermis. by Julia Hatzold (44687)

“…Of the <i>atp1b1a-/-; par2b-/-</i> double mutants, 50% did not show obvious <i>mmp9</i> staining, comparable to wild type controls (compare with <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010873#pgen.1010873.g002" target="_blank">Fig 2M</a>), and the other 50% showed weak <i>mmp9</i> staining intensity comparable to that shown in panel (G). …”

Fig 11 - by Sana Khalid (132742)

A subset of Ascl1 lineage cells continue to produce new granule neurons 30 days after initial Ascl1 expression in adult hippocampus. by Euiseok J. Kim (353912)

“…(O–V) Neurogenesis in the SGZ dramatically decreases between 12 weeks and 34 weeks of age as seen in the decrease in DCX (P,T), NeuroD1 (Q,U) and Ki67 (R,V). …”

Data_Sheet_1_Optimizing the Design of Supply Chains for Carbon Capture, Utilization, and Sequestration in Europe: A Preliminary Assessment.pdf by Federico d'Amore (9440510)

“…In addition to this, carbon utilization has often been considered as a viable option for increasing the environmental benefits, while decreasing costs of the mere capture and storage system. …”

A Genetically Hard-Wired Metabolic Transcriptome in <em>Plasmodium falciparum</em> Fails to Mount Protective Responses to Lethal Antifolates by Karthikeyan Ganesan (269200)

“…No genes were reproducibly up-regulated by more than 2-fold until 24 h after initial drug exposure, even though clonal viability decreased by 50% within 6 h. We predicted and showed that while the parasites do not mount protective transcriptional responses to antifolates in real time, <em>P. falciparum</em> cells transfected with human DHFR gene, and adapted to long-term WR99210 exposure, adjusted the hard-wired transcriptome itself to thrive in the presence of the drug. …”

Mapping and Exome Sequencing Identifies a Mutation in the <i>IARS</i> Gene as the Cause of Hereditary Perinatal Weak Calf Syndrome by Takashi Hirano (414231)

“…In order to identify the perinatal weak calf syndrome locus in a 4.04-Mb region of BTA 8, we analysed a paternal half-sibling family with a BovineSNP50 BeadChip and microsatellites. …”

An examination of the dose rate effect in mice assuming that the carcinogenic effect of radiation is life shortening resulting from a tissue reaction by Nori Nakamura (785705)

“…To separate the dose rate effect from the effects of age under long-term exposure conditions, a thought experiment was designed which consisted of 8 repeated exposures to an acute 1 Gy dose at intervals of 50 days with an assumption that the effect is additive, and the results were compared with those observed in a chronic continuous exposure experiment (20 mGy per day for 400 days, for a total of 8 Gy: Tanaka et al. …”

Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner by Qing Yang (67856)

“…We found that resveratrol inhibited the proliferation of gastric cancer cells in a dose-dependent manner. At the concentration of 25 and 50 µM, resveratrol inhibited the cell viability and diminished the clonogenic potential of gastric cancer cells. …”

Hyperacetylation of PS1 and BACE1 was suppressed by p300 specific inhibitor curcumin in N2a/APPswe cells. by Xi Lu (288663)

“…<p>(A) the p300 protein was markedly decreased in N2a/APPswe cells after being treated with curcumin; (B) curcumin dramatically reduced the enhancement effect of p300 in N2a/APPswe cells by immunocytochemistry, Magnification 400-fold, Scale bar: 50 µm; (C) curcumin treatment significantly suppressed the HATs activity in N2a/APPswe cells; (D) the Ac-H3 to PS1 and BACE1 promoter regions was much lower in N2a/APPswe cells after being treated with curcumin compared to DMSO (placebo) group; (E) the cellular Ac-H3 in N2a/APPswe cells was statistically significantly decreased after curcumin treatment; (F) N2a/APPswe cells after being treated with curcumin showed reduced binding of p300 to PS1 and BACE1 in N2a/APPswe cells. …”

Image_3_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

Image_1_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

Image_2_Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.tif by Jinyan Wang (195882)

DataSheet4_Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine.PDF by Rodolphe H. Lebeau (14031246)

“…A 50% decrease in emotionality score threshold before and after Flx, was used to separate Flx-responding mice (Flx-R, n = 18), or Flx non-responder mice (Flx-NR, n = 7). …”

A Top-Down Proteomics Platform Coupling Serial Size Exclusion Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by Trisha Tucholski (3992264)

“…Notably, within a 5 <i>m</i>/<i>z</i> window, we obtained baseline isotopic resolution for 6 distinct large proteoforms (30–50 kDa). …”

DataSheet5_Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine.pdf by Rodolphe H. Lebeau (14031246)

“…A 50% decrease in emotionality score threshold before and after Flx, was used to separate Flx-responding mice (Flx-R, n = 18), or Flx non-responder mice (Flx-NR, n = 7). …”

DataSheet3_Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine.PDF by Rodolphe H. Lebeau (14031246)

“…A 50% decrease in emotionality score threshold before and after Flx, was used to separate Flx-responding mice (Flx-R, n = 18), or Flx non-responder mice (Flx-NR, n = 7). …”

DataSheet2_Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine.PDF by Rodolphe H. Lebeau (14031246)

“…A 50% decrease in emotionality score threshold before and after Flx, was used to separate Flx-responding mice (Flx-R, n = 18), or Flx non-responder mice (Flx-NR, n = 7). …”