Identification of <i>T. gondii</i> Myosin Light Chain-1 as a Direct Target of TachypleginA-2, a Small-Molecule Inhibitor of Parasite Motility and Invasion by Jacqueline M. Leung (120235)

“…Two key components of this complex are the class XIV unconventional myosin, TgMyoA, and its associated light chain, TgMLC1. We previously showed that treatment of parasites with a small-molecule inhibitor of <i>T. gondii</i> invasion and motility, tachypleginA, induces an electrophoretic mobility shift of TgMLC1 that is associated with decreased myosin motor activity. …”

On a steepening environmental gradient, a sharp and stable range margin forms near the expansion threshold. by Jitka Polechová (5400749)

“…(<b>b</b>) As the environmental gradient steepens, the frequency of limited adaptation within the metapopulation increases (black and grey), and hence neutral variation decreases (blue). The black line gives the proportion of demes with limited adaptation after 50,000 generations, when the range margin appears stable; grey gives the proportion after 40,000 generations (depicted is an average over a sliding window of 15 demes). …”

Data_Sheet_1_Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring.docx by Teri N. Hreha (9176216)

“…In this work, we investigated how androgen exposure influences immune cell recruitment to the UPEC-infected kidney and how cell-specific activin A production affects post-pyelonephritic scar formation. …”

<em>Fabp7</em> Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype by Akiko Watanabe (36386)

“…<em>Fabp7</em>-deficient mice showed decreased PPI and a shortened startle response latency, typical of the QTL's proposed effects. …”

Inhibition modulates the position of peak energetic efficiency of information transfer. by Julia Jade Harris (7134944)

Importance of the features. by Zhi Jiang (269212)

Variable selection in the RF algorithm. by Zhi Jiang (269212)

Course of T_body of a female pup before, during and after a thunderstorm. by Nicola Erdsack (443390)

“…</b>: The thunderstorm stopped but it still rained on. <b>5:50 p.m.</b>: T_air = 19.7°C. T_body had decreased by 0.7°C to 36.9°C. …”

Interface Dynamics at a Four-Fluid Interface during Droplet Impact on a Two-Fluid System by Akash Chowdhury (6589583)

“…We investigate the interfacial dynamics involved in the impact of a droplet on a liquid–liquid system, which involves the impingement of an immiscible core liquid drop from a vertical separation onto an interfacial shell liquid layer floating on a host liquid bath. …”

Interface Dynamics at a Four-Fluid Interface during Droplet Impact on a Two-Fluid System by Akash Chowdhury (6589583)

“…We investigate the interfacial dynamics involved in the impact of a droplet on a liquid–liquid system, which involves the impingement of an immiscible core liquid drop from a vertical separation onto an interfacial shell liquid layer floating on a host liquid bath. …”

A Key Role for the Urokinase Plasminogen Activator (uPA) in Invasive Group A Streptococcal Infection by Martina L. Sanderson-Smith (430906)

“…Both C57/black 6J, and <i>AlbPLG1</i> mice expressing the human plasminogen transgene, were significantly more susceptible to invasive GAS disease than <i>uPA−/−</i> mice. The observed decrease in virulence in <i>uPA−/−</i>mice was found to correlate directly with a decrease in bacterial dissemination and reduced cell surface plasmin accumulation by GAS. …”

Comparison of sensitivity and specificity of three diagnostic tests to detect <i>Schistosoma mansoni</i> infections in school children in Mwanza region, Tanzania by Antje Fuss (5675879)

“…Reliable and accurate diagnosis plays a key role in surveillance, prevention and control of schistosomiasis. …”

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection by Jonathan Maelfait (181048)

“…We here addressed the role of A20 in club cells (also known as Clara cells) of the bronchial epithelium in their response to influenza A virus infection. …”

The role of complement activation in rhabdomyolysis-induced acute kidney injury by XuDong Huang (3178140)

“…Cobra venom factor (CVF) was administered via tail vein injection to deplete complement 12 h prior to intramuscular injection of glycerol. We found that the complement components, including complement 3 (C3), C1q, MBL-A, factor B(fB), C5a, C5b-9, and CD59, were significantly increased in rat kidneys after intramuscular glycerol administration. …”

Image_2_Periostin Contributes to Immunoglobulin a Nephropathy by Promoting the Proliferation of Mesangial Cells: A Weighted Gene Correlation Network Analysis.TIF by Jingkui Wu (9664094)

“…POSTN had very high module membership and gene significance values for creatinine (0.82 and 0.66, respectively) and eGFR (0.82 and −0.67, respectively), indicating that it is a co-hub gene. In MMCs, POSTN was upregulated by transforming growth factor β1, and stimulation of MMCs with recombinant POSTN protein resulted in an increase in the level of proliferating cell nuclear antigen (PCNA) and a decrease in that of B cell lymphoma-associated X protein, which were accompanied by enhanced MMC proliferation. …”

Table_6_Periostin Contributes to Immunoglobulin a Nephropathy by Promoting the Proliferation of Mesangial Cells: A Weighted Gene Correlation Network Analysis.DOCX by Jingkui Wu (9664094)

“…POSTN had very high module membership and gene significance values for creatinine (0.82 and 0.66, respectively) and eGFR (0.82 and −0.67, respectively), indicating that it is a co-hub gene. In MMCs, POSTN was upregulated by transforming growth factor β1, and stimulation of MMCs with recombinant POSTN protein resulted in an increase in the level of proliferating cell nuclear antigen (PCNA) and a decrease in that of B cell lymphoma-associated X protein, which were accompanied by enhanced MMC proliferation. …”

Table_10_Periostin Contributes to Immunoglobulin a Nephropathy by Promoting the Proliferation of Mesangial Cells: A Weighted Gene Correlation Network Analysis.DOCX by Jingkui Wu (9664094)

“…POSTN had very high module membership and gene significance values for creatinine (0.82 and 0.66, respectively) and eGFR (0.82 and −0.67, respectively), indicating that it is a co-hub gene. In MMCs, POSTN was upregulated by transforming growth factor β1, and stimulation of MMCs with recombinant POSTN protein resulted in an increase in the level of proliferating cell nuclear antigen (PCNA) and a decrease in that of B cell lymphoma-associated X protein, which were accompanied by enhanced MMC proliferation. …”

Table_4_Periostin Contributes to Immunoglobulin a Nephropathy by Promoting the Proliferation of Mesangial Cells: A Weighted Gene Correlation Network Analysis.DOCX by Jingkui Wu (9664094)

“…POSTN had very high module membership and gene significance values for creatinine (0.82 and 0.66, respectively) and eGFR (0.82 and −0.67, respectively), indicating that it is a co-hub gene. In MMCs, POSTN was upregulated by transforming growth factor β1, and stimulation of MMCs with recombinant POSTN protein resulted in an increase in the level of proliferating cell nuclear antigen (PCNA) and a decrease in that of B cell lymphoma-associated X protein, which were accompanied by enhanced MMC proliferation. …”

Table_8_Periostin Contributes to Immunoglobulin a Nephropathy by Promoting the Proliferation of Mesangial Cells: A Weighted Gene Correlation Network Analysis.DOCX by Jingkui Wu (9664094)

“…POSTN had very high module membership and gene significance values for creatinine (0.82 and 0.66, respectively) and eGFR (0.82 and −0.67, respectively), indicating that it is a co-hub gene. In MMCs, POSTN was upregulated by transforming growth factor β1, and stimulation of MMCs with recombinant POSTN protein resulted in an increase in the level of proliferating cell nuclear antigen (PCNA) and a decrease in that of B cell lymphoma-associated X protein, which were accompanied by enhanced MMC proliferation. …”

Table_3_Periostin Contributes to Immunoglobulin a Nephropathy by Promoting the Proliferation of Mesangial Cells: A Weighted Gene Correlation Network Analysis.DOCX by Jingkui Wu (9664094)

“…POSTN had very high module membership and gene significance values for creatinine (0.82 and 0.66, respectively) and eGFR (0.82 and −0.67, respectively), indicating that it is a co-hub gene. In MMCs, POSTN was upregulated by transforming growth factor β1, and stimulation of MMCs with recombinant POSTN protein resulted in an increase in the level of proliferating cell nuclear antigen (PCNA) and a decrease in that of B cell lymphoma-associated X protein, which were accompanied by enhanced MMC proliferation. …”