Mcl-1 degradation is slowed by a T163E mutation (but not T163A) in transfected CHO cells. by Shanna K. Nifoussi (128297)

“…In Panel B, the decline in Mcl-1 expression at 3 hours in 2 independent experiments ranged from 53–66% with WT-Mcl-1, 25–54% with Mcl-1-S162A, and 25–50% with Mcl-1-T163A. While the decline in expression with WT-Mcl-1 appeared be slightly greater than that seen with Mcl-1-T163A, this was not a consistent finding. …”

Epithelial cell death induced by cFlip deletion is counteracted by vFLIP <i>in vivo</i>. by Barbara Ruder (8379354)

DRP2B is partially required for flg22-induced endocytosis of FLS2. by John M. Smith (676719)

“…Representative maximum-intensity projection images and zoomed insets of FLS2-GFP fluorescence are shown, with bright pixels corresponding to increased abundance of FLS2-GFP at a given location. Scale bars = 10 µm. (D) Quantification of FLS2-GFP in puncta at 0, 35–45 or 50–60 min after elicitation with 1 µM flg22 indicates that loss of <i>DRP2B</i> resulted in ∼20% decrease in flg22-stimulated endocytosis of FLS2-GFP (35–45 min, P = 0.0204; 50–60 min, P = 0.0396). …”

LZP is required for TG secretion. by Jiao-Xiang Wu (6323045)

ER stress sensors and EBI3 are expressed during chondrogenic differentiation of MSCs. by Tong Zhang (103827)

Analgesic effect of a cholinergic agonist (carbachol) in a sural nerve ligation-induced hypersensitivity mouse model by Nodoka Kato (18298748)

“…</p> <p>SN ligation resulted in a significant decrease in pain threshold for mechanical stimulation 1 day after ligation. …”

Astrocytic expression of Pla2g3 by chronic oxidative stress. by Daishi Yui (795083)

Increased expression of Pla2g3 in frontal cortex of AD patients. by Daishi Yui (795083)

Representative Boolean gating strategy for the analysis of the cytokine co-expression profiles of CD4+ T cells after stimulation with T. cruzi antigens. by María Ailén Natale (6843422)

Image_2_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Image_3_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Image_6_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Image_1_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

DataSheet_1_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.xls by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

DataSheet_2_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.xls by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Image_5_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Image_4_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.jpeg by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Table_1_Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.xls by Diogo F. T. Veiga (12282320)

“…At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. …”

Liver injury analysis. by Véronique Cheff (14559285)

DICER+AGO2 enzymes cleave fluorogenic substrates into duplex products that are unstable at T>25°C. by Mark A. Bernard (608655)