Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

100P homozygous mice show overall decrease in proportions of PV-expressing cells in the P21 neocortex. by Malgorzata Borkowska (3166719)

Effects of specific anti-miRs for the five miRNAss on the IC50 of cisplatin (A) and paclitaxel (B) in Hec1A cells. by Taek Sang Lee (494682)

Temporal distributions of inscriptions and occupations using uniform 50-years-long timeblocks. by Vojtěch Kaše (6156971)

Resveratrol decreases cell proliferation in a time and dose dependent manner. by Mehtap Kilic Eren (591048)

Development of a cAMP sensor with decreased pH sensitivity. by Katy L. Everett (461878)

Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric <i>in silico</i> ROCOCO trial by Daniëlle B. P. Eekers (5560430)

Effect on the metabolic clearance rate (MCR) of CK under the inhibition of recombinant CYP2C9 and CYP3A4. by Jian Xiao (253329)

“…The MCRs of CK were significantly decreased compared with those of the control for CYP3A4 and CYP2C9.…”

Average time necessary to disperse 50% of the population introduced (half-life time) in experiments and theoretical simulations, according to the number of woodlice initially intro... by Pierre Broly (228993)

Diversity of intestinal microbiota in the feces of finishing pigs fed a diet supplemented with or without <i>B</i>. by Jun Ho Song (1675123)

Increased bleeding time in E2, P4 and E2+P4-treated mice. by Marie-Cécile Valéra (4014953)

Drugs IC₅₀s data during the study period. by Winnie Okore (14139712)

Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in <i>Neisseria gonorrh... by Joshua Tomberg (1345956)

“…Agents Chemother. 50</i>, 3638−3645]. However, we observed that the minimum inhibitory concentrations (MICs) of penicillin, ceftriaxone, and cefixime for a wild-type strain (FA19) containing a <i>penA</i> gene with these three mutations increased only 1.5-, 1.5-, and 3.5-fold, respectively. …”

Immunization for EAE decreased the counts of CD4+ and CD8+ T-PBLs in DA rats. by Mirjana Nacka-Aleksić (3342095)

Decrease in the number of rod microglial secondary branches post-injury. by Samuel E. Taylor (564686)

Aerobic exercise increases cardiac NO production and decreases oxidative stress after TAC. by Bin Wang (30851)

Kaplan Meier curves of survival of patients with severe sepsis/septic shock classified in function of a decrease of procalcitonin levels higher (continuous line) or lower (dashed line) than 50% from day 0 to 5 of ICU stay. by Juan-Jesús Ríos-Toro (3907732)

PiCRUST prediction of the functional potential of a microbial community based on 16S rRNA gene sequencing data. by Jun Ho Song (1675123)

<i>USP28</i> protein level was decreased by hypoxia signaling via both protein degradation and transcriptional repression in A549 cells. by Qin Li (36669)

“…(C) Hypoxia decreased <i>USP28</i> mRNA levels in A549 cells. A549 cells were cultured in 1% O₂ for 24 hr. …”

Effect of AGPAT3 downregulation on the mTORC1 signaling pathway. by Hadi Alizadeh (20854757)

Subjects: