Cisd2 deficiency disrupts Ca²⁺ homeostasis via a dysregulation of Serca2a activity and this then results in mitochondrial Ca²⁺ overload and dysfunction in car... by Chi-Hsiao Yeh (7474556)

“…Scale bar, 5 μm. (N) Serca2a (Ca²⁺-ATPase) activity was measured as the decrease in the absorbance at 340 nm using heart tissue from the various genotypes. …”

MiR-29a targets PTEN. by Guangyao Kong (185282)

“…Empty pcDNA3.0 plasmid (200 ng) was used as a negative control. (C) Luciferase reporter gene assay showed that the decreased luciferase activities of PTEN 3′UTR reporter (PTEN 3′UTR-1 or PTEN 3′UTR-2) in HepG2 cells mediated by miR-29a overexpression (200 ng) was rescued by a miR-29a inhibitor in a dose dependent manner (30, 50, and 100 nM). …”

Modulation of Aβ-induced deleterious signaling. by Tao Yang (184280)

“…<p>For each study, LM11A-24 and -31 were present at 100 nM and NGF at 50 or 100 ng/ml. …”

Identity between upstream stripes and Alu-sequences and their expression as a function of upstream poly(A)-segments of the GA-sequences. by Guenter Albrecht-Buehler (266704)

“…<p>The GPxIs show portions of the GA-complexes of human chr.1 after sorting them by the decreasing size of poly(A)-segments at the upstream end of the GA-sequences. …”

CORT triggered a slow-onset increase in GluN2A/GluN2B ratio. by Yiu Chung Tse (340737)

“…<p>(<b>A</b>) Plots of NMDAR-EPSC amplitude from control and CORT-treated slices against time show decreased EPSC amplitude after sequential application of Ro (1 µM; for 30 min) and a mixture of Ro and a subunit non-selective NMDAR antagonist APV (50 µM; for 10 min). …”

Effects of sialidase treatment on substantia nigra dopamine neurons. by Jay S. Schneider (671374)

“…<p>Sub-acute MPTP treatment (aCSF-MPTP) resulted in significant decreases in the number of tyrosine hydroxylase immunopositive (A.) and Nissl-stained (B.) cells in the substantia nigra pars compacta. …”

Data selection by changes in the firing rate. by Huu Hoang (9188747)

“…<p>A: the histograms of firing rate change by drug treatments (decreased by CBX and increased by PIX) compared to the CON condition. …”

Targeting hTERT Promoter G‑Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy by Wei Long (411482)

“…Human telomerase reverse transcriptase (hTERT) may have noncanonical functions in transcriptional regulation and metabolic reprogramming in cancer cells, but it is a challenging target. We thus developed small-molecule ligands targeting hTERT promoter G-quadruplex DNA structures (hTERT G4) to downregulate hTERT expression. …”

Organic Reaction as a Stimulus for Polymer Phase Separation by Masami Naya (4339054)

Wind speed box plots at observation stations (red) and ERA5 cells (green) at heights of 10m and 100m, respectively. by Weidong Ji (129916)

Developmental patterns of expression of tectal EphA3 and retinal ephrin-As and Tyr-602 phosphorylated-EphA4. by Ana Laura Ortalli (159899)

“…The expression of ephrin-A2 extends along all the retina, presenting a decreasing naso-temporal gradient mainly in the RGCs. …”

Flow of premises through the study. by Eleni Mantzari (6991172)

“…The daily volume of wine sold increased during the intervention period by 232 ml (95% CI [13, 487], <i>p</i> = 0.035) or 7.2% (95% CI [0.4%, 14.5%]). Daily revenues decreased by 5.0% (95% CI [9.6%, −0.3%], <i>p</i> = 0.038).…”

Exploration of 2‑((Pyridin-4-ylmethyl)­amino)­nicotinamide Derivatives as Potent Reversal Agents against P‑Glycoprotein-Mediated Multidrug Resistance by Qianqian Qiu (3859564)

“…In-depth studies demonstrated <b>9n</b> has high potency (EC₅₀ = 119.6 ± 6.9 nM), low cytotoxicity, and long duration (>24 h) in reversing adriamycin (ADM) resistance in K562/A02 cells. …”

Photomicrographs of DG from control gerbils and during and after infection with <i>Giardia</i>. by Angélica González Maciel (18946369)

A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells by V Bhattacharjee (681247)

“…A sublethal dose (50 nM) of the drug was used to model situations of limiting drug availability to PCa tumors in vivo. …”

Growth and <i>in vitro</i> differentiation of <i>B</i>. <i>cinerea</i> B05.10 (WT) and mutants generated in this study. by Thomas Leisen (9248883)

Baseline characteristics of the study subjects^a. by Ga Young Lee (1809919)

CgHtz1 levels are reduced under high-iron conditions. by Mahima Sagar Sahu (18555062)

The U937 cell line was seeded at 2 x 10⁵ cells per well. by Janani Madhuravasal Krishnan (19736002)

The U937 cell line was seeded at 1 x 10⁵ cells per well. by Janani Madhuravasal Krishnan (19736002)