MYD88, IRAK3 and Rheumatoid Arthritis pathogenesis: Analysis of differential gene expression in CD14 + monocytes and the inflammatory cytokine levels. by Gomes da Silva, Isaura Isabelle Fonseca

“…Rheumatoid arthritis (RA) is a well-known chronic inflammatory disorder. Two molecular players act in the inflammation balance of the disease: MyD88 (Myeloid differentiation primary response 88) is related to TLR (Toll-like receptors) response and promotes the formation of myddosome complex resulting in increased inflammation; IRAK3 (Interleukin-1 receptor associated kinase 3) acts suppressing the myddosome complex thus decreasing inflammation. …”
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Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress by Fatima, Munazza T

“…Importantly, SESN2 silencing, unlike thapsigargin, caused a dramatic decrease in protein expression and phosphorylation of Akt, a critical pro-survival hub and component of the AMPK/Akt/mTORC1 axis. …”
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Unraveling the future productivity burden of cardiovascular disease in Qatar: Investigating the modifiable risk factors control in type 2 diabetes by Abushanab, Dina

“…ResultsThe base-case analysis projected that CVD in T2D would result in an estimated 2,096,536 PALYs (95 % confidence interval, 1,689,272–2,182,939), contributing US$225.46 (95 %CI, 1,689,272–2,182,939) billion to the country's GDP. …”
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Correlating the microstructure to mechanical properties and wear behavior of an accumulative back extruded Al-Mg2Si in-situ composite by Ebrahimi, M.

“…Surprisingly, the wear loss was dramatically decreased in processed materials in comparison to the as-received one. …”
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Micromodel Study on Colloid Retention and Mobilization under different Geo-Chemical Conditions during Single and Two-Phase Flow by Nishad, Safna

“…The retention of three different types of colloids (i.e., favorable, unfavorable, and medium favorable conditions) was observed visually in a micromodel. …”
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Epidemiology of herpes simplex virus type 2 in sub-Saharan Africa: Systematic review, meta-analyses, and meta-regressions by Harfouche, Manale

“…Background: Herpes simplex virus type 2 (HSV-2) infection is a prevalent, sexually transmitted infection with a sizable disease burden that is highest in sub-Saharan Africa. …”
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Coalition game theoretic P2P trading in a distribution network integrity-ensured local energy market by M., Imran Azim

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NOVEL HIGHLY ANTIBACTERIAL CORROSION RESISTANT NIP-CEO2-C3N4 NANO-COMPOSITE COATINGS by ARRO, CHRISTIAN RANDELL

“…On the contrary, notably, the heat treatment led to a decrease in the resistivity of composite coatings compared to their corresponding as-prepared ones. …”
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Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region by Dagenais, Renée

“…Results Five studies met the inclusion criteria. CYP2C9, CYP2C19, and multidrug resistance protein 1 C3435T variants were evaluated. …”
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Microwave-Assisted Solvothermal Synthesis of Mo-Doped TiO2 with Exceptional Textural Properties and Superior Adsorption Kinetics by Ahmad, Yahia H.

“…The average particle size ranged between 9.7 and 27.5 nm and it decreased with increasing the Mo content. Furthermore, Mo-TiO2 revealed mesoporous architectures with a high surface area ranging between 170 and 260 m2 g−1, which is superior compared to previously reported Mo-doped TiO2. …”
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Correlation of structural and mechanical properties for Al-Al2O3-SiC hybrid metal matrix composites by Ahamad, Naseem

“…Hardness of hybrid composites increases upto 5 wt.% variation of ceramic reinforcements i.e. Al2O3-SiC after that it decreases. Impact strength of hybrid composite has been increased with an increase in weight percentage of ceramic. …”
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دراسة تأثير تركيز تيترا أيزوبروبكسيد التيتانيوم (TTIP) على بعض مواصفات ألياف ثنائي أكسيد التيتانيوم النانوية المغزولة كهربائياً... by طهماز, غزل

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Modeling of mass transport of aqueous solutions of multi-solute organics through reverse osmosis membranes in case of solute–membrane affinity: Part 1. Model development and simula... by Mehdizadeh, H.

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Accelerated weathering effects on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and PHBV/TiO2 nanocomposites by Antunes, A.

“…It also slowed down the decrease in mechanical properties. The mechanical properties were shown to gradually decrease for the PHBV/TiO2 nanocomposites, whereas a sharp drop was observed for the neat PHBV after an accelerated weathering exposure. …”
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Investigational Study for the efficiency of Fe3O4@SiO2 nanoparticles in the Oil Recovery Process using glass micromodel by Elhaj, Wamda

“…For the oil recovery process, the Fe3O4 was applied for the inhibition (i.e., decrease) of oil sedimentation, and the SiO2 NPs were applied for wettability alteration and IFT reduction. …”
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation by Mai S., El-Shoukrofy

“…As well, the expression levels of 20-HETE, Il-1β and TNF-α were decreased in LPS-challenged RAW264.7 macrophages upon treatment with compound 2a. …”
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Synthesis and characterization of stir casted Cu-ZrO2-Graphite hybrid metal matrix composites for thermal management structures by Mittal, Prateek

“…The properties of the prepared MMCs were found to be dependent on the reinforcements content present in the MMCs. ZrO2 and Graphite reinforcements were added (0.5–0.5, 1.0–1.0, 1.5–1.5 and 2.0–2.0 wt %) in the four composite samples prepared via stir casting. …”
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Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling. by Akhtar, Sabah

“…The SNG-mediated apoptosis appears to be resulted from suppression of the constitutively active STAT3 with a concomitant increase in expression of protein tyrosine phosphatase (SHP-1). SNG treatment of MM cells leads to down-regulation of the anti-apoptotic proteins including cyclin D, Bcl-2, Bclxl, and XIAP. …”
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Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells by Mannino, Federica

“…In addition, BCP regulated AKT, Wnt1, and beta-catenin expression, showing that CB2R stimulation may decrease cancer cell proliferation by modulating Wnt/β-catenin signaling. …”
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Results from the first culturally tailored, multidisciplinary diabetes education in Lebanese adults with type 2 diabetes: effects on self-care and metabolic outcomes by Sukkarieh-Haraty, Ola

“…This pilot-study tested the effect of culturally-tailored education targeting diabetes selfcare on glycemia and cardiovascular risk factors of Lebanese with type 2 diabetes mellitus (T2DM) (n = 27; Age: 61 ± 10 yrs, 59% males, HbA1c: 8.98 ± 1.38%). …”
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