Compound CID 9998128 Is a Potential Multitarget Drug for Alzheimer’s Disease by Nguyen Quoc Thai (5348798)

“…By all-atom simulation and molecular mechanics Poisson–Boltzmann surface area (MM-PBSA) method, we have demonstrated that this compound strongly binds to both amyloid β42 (Aβ₄₂) fibrils and β-secretase, and the van der Waals interaction dominates over the electrostatic interaction in binding affinity. …”

Compound CID 9998128 Is a Potential Multitarget Drug for Alzheimer’s Disease by Nguyen Quoc Thai (5348798)

“…By all-atom simulation and molecular mechanics Poisson–Boltzmann surface area (MM-PBSA) method, we have demonstrated that this compound strongly binds to both amyloid β42 (Aβ₄₂) fibrils and β-secretase, and the van der Waals interaction dominates over the electrostatic interaction in binding affinity. …”

Configuration of control site trapping webs illustrating the distribution of Rhodamine B marked captures (blue), the bait distribution zone (dashed line), and 90% (red) and 50% (gr... by James C. Beasley (392355)

Configuration of treatment site trapping webs illustrating the distribution of Rhodamine B marked captures (blue), the bait distribution zone (dashed line), and 90% (red) and 50% (... by James C. Beasley (392355)

Predictions of random forests (RF), gradient boosting machines (GBM), and neural networks (NN) trained on 12 covariates chosen using subjective feature selection. by Dennis Ochola (11626912)

Predictions of random forests (RF), gradient boosting machines (GBM), and neural networks (NN) trained on 17 covariates selected after recursive feature selection. by Dennis Ochola (11626912)

Damsin (D) and ambrosin (A) treatment decreases the CSC population. by Wendy Soria Sotillo (4408105)

Temporal distributions of inscriptions and occupations using uniform 50-years-long timeblocks. by Vojtěch Kaše (6156971)

Subjects:

Network and biological properties of high quality marine food webs, ordered by decreasing connectance. by Tomás Ignacio Marina (5309588)

“…<p>Network and biological properties of high quality marine food webs, ordered by decreasing connectance.</p>…”

Affinity analysis results (with a confidence level above 50%). by Marta R. Jabłońska (8491404)

The distributions of the end-simulation adolescence-limited proportion when (a) <i>k</i> is increased or decreased by 50%, (b) <i>c</i> is increased or decreased by 50%, (c) <i>γ</i> is increased or decreased by 50%, and (d) Δ<i>e</i> is increased or decreased by 50%, compared against the benchmark distribution <i>F</i>(<b>p</b>₀) for the parameters shown in Table 1. by Jia Ning Leaw (752775)

Primary endpoint analysis, i.e., time to first occurrence of combined event of 50% decrease in eGFR or ESRD. by Rozita Mohd (7411322)

A line graph illustrates that the proportion of reliable websites decreased and commercial advertisements increased as the search result ranks decreased. by Xi Zhu (551361)

Detailed meta–analyses in untreated hypothyroid patients compared with controls for each HRV parameters: RR intervals, SDNN, RMSSD, pNN50, TP, LF, HF, LF/HF. by Valentin Brusseau (12769704)

Disaggregation of consumer biomass response across the food web. by Vianney Guibourd de Luzinais (16871842)

Subjects:

Pre-treatment LLM, month of start and end of sustained (≥ 4 months) decrease in LLM by ≥ 50% from pre-treatment LLM, to < 8100 mf/ml or < 30000 mf/ml by treatment arm for participants with a sustained decrease by ≥ 50%. by Joseph Kamgno (81039)

“…<p>Pre-treatment LLM, month of start and end of sustained (≥ 4 months) decrease in LLM by ≥ 50% from pre-treatment LLM, to < 8100 mf/ml or < 30000 mf/ml by treatment arm for participants with a sustained decrease by ≥ 50%.…”

Decreased Risk of Ventilator-Associated Pneumonia in Sepsis Due to Intra-Abdominal Infection by François Philippart (319324)

“…The IAI group had fewer patients with VAP (56 [19.3%] <i>vs</i>. 806 [34.5%], <i>P</i><0.01) and longer time to VAP (5.0 <i>vs</i>.10.5 days; <i>P</i><0.01). After adjustment on independent risk factors for VAP and previous antimicrobial use, IAI was associated with a decreased risk of VAP (hazard ratio, 0.62; 95% confidence interval, 0.46–0.83; <i>P</i><0.0017). …”

The EP (electrostatic potentials) of Rrd1-(like proteins) from four distinct species was compared using the webPIPSA service. by Mohd Kashif (769104)

In-phase (A) and opposed phase (B) chemical shift MR images of a 51-year-old male demonstrate hepatic steatosis, consistent with areas of decreased signal intensity on an opposed-p... by Andrzej Cieszanowski (635105)

Expression of ApoB-50 decreased lipid accumulation and inhibited HCV production. by Bei Wang (116772)