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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
Published 2025“…Compound 2a activated PPARγ with an EC50 value of 3.4 μM in a Gal4-hybrid reporter gene assay, indicating partial agonistic action. …”
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Biodegradable thermoplastic polyurethane composites as potential plating systems in pediatric facial fractures
Published 2022“…Due to the rapid growth of facial bone in the pediatric age group, the use of metallic plates would require a second surgical intervention to remove it. The alternative is biodegradable plating systems which are safe but not without complications, including learning curve, decreased stability, cost, and infection. …”
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Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome
Published 2022“…We measured 1069 serum metabolites and correlated them to clinical features. …”
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506
Hot and Hypoxic environments inhibit simulated soccer performance and exacerbate performance decrements when combined
Published 2016“…Twelve male University soccer players completed three familiarization sessions and four randomized crossover experimental trials of the intermittent Soccer Performance Test (iSPT)in normoxic- temperate(CON:18◦C50%rH),HOT(30◦C;50%rH),HYP(1000m;18◦C50%rH),and HH(1000m;30◦C;50%rH).Physical performance and its performance decrements, bodytemperatures(rectal,skin,and estimated muscle temperature), heartrate(HR), arterial blood oxygen saturation(SaO2), perceived exertion, thermal sensation(TS), body mass changes, blood lactate, and plasma volume were all measured. …”
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507
Privacy-preserving federated learning cyber-threat detection for intelligent transport systems with blockchain-based security
Published 2022“…The results indicated that the precision and accuracy decreased by 7.1% on average with comparable F1-score and recall. …”
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Morphology and property changes in PLA/PHBV blends as function of blend composition
Published 2018“…wt.% PHBV. For samples between 50/50 and 10/90 PLA/PHBV the tensile strength and Young?…”
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Ion beam modification of surface properties of polyethylene
Published 2003“…In contrast, ion bombardment does not produce significant changes of tribological parameters in 50–50 blend and LDPE.…”
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Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
Published 2020“…Stretching the RPV for 10 minutes significantly decreased phosphorylation of LKB1, AMPK, and eNOS, while APN significantly increased p-LKB1, pAMPK, and p-eNOS in stretched vessels. …”
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511
Dicarbonyl stress, protein glycation and the unfolded protein response
Published 2021“…We propose that dicarbonyl stress, through increased formation of MG-glycated proteins, may be an important physiological stimulus of the UPR and Glo1 inducers may provide a route to effective suppression and therapy. …”
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512
Centrifugal Compressor Spiral Dry Gas Seal Simulation Working at Reverse Rotation
Published 2013“…The open force corresponding to reverse rotation increased with a value 1.5kN for both the 100 overlap and 50% forward overlap seal faces, but using seal face with 50% backward overlap failed to enhance the open force at reversal condition.…”
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513
Investigation of flexible polymer-Tl2O3 nanocomposites for x-ray detector applications
Published 2019“…We report on the synthesis and characterization of composite semiconducting polymer – nanoparticle membranes for X-ray detection applications. …”
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Effect of gamma irradiation on the microstructure and morphology of polyethylene oxide and polyvinyl alcohol blends
Published 2010“…Thin films of a blend of 90, 75, 50 (wt/wt%) percentage of polyethylene oxide and polyvinyl alcohol were synthesized and irradiated with 5, 25, 50, 100 and 200 kGy. …”
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Maximum Likelihood Estimation in the Inverse Weibull Distribution with Type II Censored Data
Published 2022“…We consider maximum likelihood estimation for the parameters and certain functions of the parameters in the Inverse Weibull (IW) distribution based on type II censored data. …”
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Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells
Published 2017“…ZNE treatment also caused a concentration- and time-dependent reduction in the TNF-α-induced expression of matrix metalloproteases MMP-2 and MMP-9, NF-κB, and cell adhesion molecules ICAM-1 and VCAM-1. Furthermore, ZNE decreased the adhesion of THP-1 monocytes to HASMCs and endothelial cells in a concentration-dependent manner. …”
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Occurrence, origin and potential ecological risk of dissolved polycyclic aromatic hydrocarbons and organochlorines in surface waters of the Gulf of Gabès (Tunisia, Southern Mediter...
Published 2022“…The results demonstrated a wide range of concentrations (ng L−1) with the following decreasing order: Ʃ16 PAHs (17.6–71.2) > Ʃ20 PCBs (2.9–33.7) > Ʃ6 DDTs (1.1–12.1) > Ʃ4 HCHs (1.1–14.8). …”
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