Effects of 1466 on capsid and pgRNA encapsidation compared to known CAM-A and CAM-E inhibitors. by Daniel P. Bradley (10306893)

Effects of SUN N8075 on the decreased motor neurons and VGF immunoreactivity of the spinal cords of SOD1G93A mice and sporadic ALS patients. by Masamitsu Shimazawa (59118)

NM proteins binding the XmnI sequence in PCa cell lines. by Paola Barboro (316507)

“…The decrease in 22Rv1 and PC3 with respect LNCaP cells was significant (*P = 0.004, **P<10⁻⁵). …”

The effect of TRPV4 activation and KCa channel blockers on transepithelial electrical resistance (TEER) of mCCDcl1 cells grown to confluency on permeable supports (see Materials an... by Yue Li (102191)

“…Each blocker (TRAM-34, Apamin, IbTX, TQ) or a cocktail (4X Blockers) of KCa channel blockers showed an increase in TEER. The decrease in TEER upon addition of GSK101 averaged 0.74 ± 0.027 (n = 3). …”

Datasheet1_Impact of lockdown on children with type-1 diabetes: returning to the community was associated with a decrease in HbA1c.pdf by Benjamin Morat (17677977)

“…No significant difference was observed between medians of HbA1c_mean and HbA1c_after values (8.37% [7.88; 9.32%] vs. 8.50% [7.70; 9.50%], respectively; p = 0.391). …”

Datasheet2_Impact of lockdown on children with type-1 diabetes: returning to the community was associated with a decrease in HbA1c.pdf by Benjamin Morat (17677977)

“…No significant difference was observed between medians of HbA1c_mean and HbA1c_after values (8.37% [7.88; 9.32%] vs. 8.50% [7.70; 9.50%], respectively; p = 0.391). …”

Contribution of direct emissions, seed, compost, other field operations, irrigation, mineral fertilisers, pesticides and transport of inputs to the climate change impact of conservation agriculture popcorn as a function of the percentage of impact allocated to compost: 7.2% (this study), 3.6% (50% decrease), 10.8% (50% increase), and 100% (original life cycle inventory from AGRIBALYSE; Avadi (2020)). by Maria Vittoria Guidoboni (15852669)

“…<p>Contribution of direct emissions, seed, compost, other field operations, irrigation, mineral fertilisers, pesticides and transport of inputs to the climate change impact of conservation agriculture popcorn as a function of the percentage of impact allocated to compost: 7.2% (this study), 3.6% (50% decrease), 10.8% (50% increase), and 100% (original life cycle inventory from AGRIBALYSE; Avadi (2020)).…”

HAOSMCs lacking CD9 display altered actin arrangement and a decrease in active RhoA and collagen gel contraction. by Michael J. Herr (428546)

Graphs of marginal mean values of the studied parameters for dolphin kick, flutter kick and breaststroke kick with and without diving gear (Parameters that were not statistically d... by Marek Rejman (9199616)

Reduced RabGEF1 expression decreases NGF-induced TrkA phosphorylation but not TrkA internalization. by See-Ying Tam (828866)

Kaplan-Meier survival curves for overall survival of MBC by highest tertile of IFN-γ signature vs. the lowest two tertiles. by Christina Gillezeau (5348660)

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Study flow diagram. by Christina Gillezeau (5348660)

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Kaplan–Meier survival curves for overall survival of NMIBC by highest tertile of IFN-γ signature vs the lowest two tertiles. by Christina Gillezeau (5348660)

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Sample flow diagram. by Christina Gillezeau (5348660)

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Kaplan-Meier survival curves for overall survival of MIBC by highest tertile of IFN-γ signature vs the lowest two tertiles. by Christina Gillezeau (5348660)

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Kaplan-Meier survival curves for progression-free survival of MIBC by highest tertile of IFN-γ signature vs the lowest two tertiles. by Christina Gillezeau (5348660)

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Characteristics of bladder cancer patients by stage. by Christina Gillezeau (5348660)

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Hazard ratios (HR) and 95% confidence intervals (CI) for the association between INF- γ signature levels and death among bladder cancer patients by stage. by Christina Gillezeau (5348660)

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Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”