Image_5_Identification of COP9 Signalosome Subunit Genes in Bactrocera dorsalis and Functional Analysis of csn3 in Female Fecundity.JPEG by Jing Zhang (23775)

“…The expression level of EcRB1 and USP, which encode the heterodimer receptors of 20E, and vitellogenin transcripts (Vg1 and Vg2) was suppressed in the fat body of female adults injected with csn3dsRNA. Decreased level of Vg1 protein was confirmed by means of Western blots. …”

ACE2 human variants that affect ACE2/SARS-CoV-2 S protein complex interaction energy for 6m0j. by Javier Delgado Blanco (9740245)

Longitudinal lung function readouts. by Zahra Khalajzeyqami (6865475)

BAL cells count at different time-points. by Zahra Khalajzeyqami (6865475)

Longitudinal micro-CT assessment. by Zahra Khalajzeyqami (6865475)

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Effects of ischemia and <i>low pH plus G6P</i> treatments on mPTP opening under de-energized conditions. by Gonçalo C. Pereira (9022700)

Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth fact... by Bei Cao (141848)

“…Coadministration of itraconazole increased the AUC_0-inf of limertinib by 289.8% (GLSM ratio, 389.8%; 90% CI, 334.07–454.82), but decreased that of CCB4580030 by 35.96% (GLSM ratio, 64.04%; 90% CI, 50.78–80.77).…”

Tat enhances vIL-6-induced angiogenesis and tumorigenesis through inactivation of PTEN and GSK-3β signals in CAM model. by Feng Zhou (76988)

“…The quantification of blood vessels was expressed as the mean ± SD (n = 5 to 8). (<b>E</b>) Overexpression of GSK-3β decreased the promoted effect of Tat on vIL-6-mediated tumorigenesis. 4E3 cells were treated as in (D). …”

Simultaneous detection of <i>V</i>. <i>cholerae</i> O1 and O139 using the Vch-UPT-LF strip. by Min Hao (3233571)

“…<i>cholerae</i> O139 decreased ten-fold. All quantification deviations were less than one order of magnitude.…”

Tubulin modifications and gamma-tubulin distribution in the tegument. by Inés Guarnaschelli (18102211)

Image 1_A comprehensive immune repertoire signature distinguishes pulmonary infiltration in SARS-CoV-2 Omicron variant infection.jpeg by Xuechuan Li (14430114)

“…</p>Results<p>Patients with pulmonary infiltration exhibit lymphopenia, a decreased proportion of the overall TCR repertoire alongside an increased BCR repertoire, reduced IGHD and IGHM isotype expression, a shorter mean CDR3 length for TRG, and a longer mean length for TRD, as well as diminished clonality and diversity in the TCR/BCR repertoire. …”

Effects of conivaptan on brain water content (BWC), blood-brain-barrier (BBB) disruption, plasma and urine sodium and osmolality. by Emil Zeynalov (596088)

“…Following MCAO, Evans Blue (EB) extravasation index (I/C) was increased in vehicle treated mice, and reduced in conivaptan treated mice, naïve, n = 5, vehicle, n = 8, Conivaptan 0.2 mg, n = 8. (C, D) Conivaptan treatment of 0.2 mg resulted in an elevation of plasma sodium and osmolality, and decreased urine sodium and osmolality due to aquaresis. …”

Data_Sheet_1_High Level of SARS-CoV-2 Infection in Young Population Is a Predictor for Peak Incidence.PDF by Haeyoun Choi (11001667)

“…The fatality rate was 2.5-fold higher during peak transmission periods than in base periods. …”

Characteristic mechanical properties of clotting platelet rich (PRP) and platelet poor plasma (PPP) as assessed by application of ARF at 7.5 kHz. by Caroline W. Wang (749474)

“…(<b>e</b>) During clotting in the PPP sample the Kelvin-Voigt viscous (μ) and elastic (k) parameters increased 1107 fold and 6.9 fold respectively. (<b>f</b>) During clotting in the PRP sample the average fold difference of viscous (μ) and elastic (k) parameters of the clot as compared to PPP between 15 and 21 min were 1.3 fold and 11 fold larger, respectively.…”

Smoking impact on fibrosis and cancer gene expression. by Lorise C. Gahring (271630)

“…Even at this low magnification the increased dysplasia of the bronchial lining is visible (asterisks). Bar = 50 microns. B. Plots show the relative expression of selected pro-fibrotic genes in the α7^G or the α7^E260A:G and the relative impact of either LPS (from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.ref007" target="_blank">7</a>]) or CS (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.t002" target="_blank">Table 2</a>). …”

Changes to distal lung structure of both α7 genotypes with and without CS exposure. by Lorise C. Gahring (271630)

“…In these representative sections the arrows point to AMs and in the α7^E260A:G arrow heads identify regions of increased cellularity that produce alveolar sacs of decreased size. …”

Expression levels of <i>Alox15</i>, <i>Hmox1</i> and <i>Fth1</i> in pulmonary myeloid cell populations. by Emilie Pollenus (10147748)

Discontinuous epitopes predicted in ElliPro from CV777, 2013MMV and SARS-CoV-2 M protein models. by Alan Rodríguez-Enríquez (12065923)

“…B) 2013MMV M protein. C) SARS-CoV-2 M protein from AlphaFold. D) SARS-CoV-2 M protein from Feig lab. …”