NDI1/AOX ectopic expression maintains DNA methylation while not completely rescuing metabolism. by Oswaldo A. Lozoya (766244)

“…By maintaining NADH oxidation in the mitochondria, flux through the TCA cycle is largely normalized, “turning off” the polyamine/MTA salvage response that in turn decreases levels of SAM. Decrease in degradation of amino acids to feed the TCA diminishes flux through the urea cycle, decreasing the input of ornithine to Put biosynthesis. 5-MeTHF, 5-methyltetrahydrofolate; acetyl-CoA, acetyl coenzyme A; AOX, alternative oxidase; Bet, betaine; Cho, choline; Cys, cysteine; Δ%mCG, DNA methylation differences versus average of day 0; DEG, differentially expressed gene; DMG, differentially methylated gene; DML, differentially methylated loci; DN-POLG, dominant-negative DNA polymerase gamma transgene; dSAM, decarboxylated S-adenosylmethionine; ETC; electron transport chain; Met, methionine; MTA, 5-methylthioadenosine; NADH, nicotinamide adenine dinucleotide reduced; NDI1, nicotinamide adenine dinucleotide reduced dehydrogenase-like 1; OXPHOS, oxidative phosphorylation; Put, putrescine; RPM, reads per million reads; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; Ser, serine; Spd, spermidine; Spm, spermine; Succ, succinate; TCA, tricarboxylic acid.…”

Table_1_Assessment of different head tilt angles in volumetric modulated arc therapy for hippocampus-avoidance whole-brain radiotherapy.docx by Cuiyun Yuan (9018989)

“…The 5 groups of tilt angle were as follows: [0°,10°), [10°,20°), [20°,30°), [30°,40°), and [40°,45°]. …”

Shortened Relative Leukocyte Telomere Length is Associated with Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes- Analysis from the Hong Kong Diabetes Registe... by Feifei Cheng (8985345)

“…</p> <p><b>Results: </b>Mean (SD) follow-up was 13.4(5.5) years. rLTL was correlated inversely with age, diabetes duration, blood pressure, HbA_1c, urine ACR and positively with eGFR (all P<0.001). …”

<i>NUAK</i> and <i>stv</i> genetically interact in muscle tissue. by David Brooks (5369636)

“…Areas that lack phalloidin staining (white dotted outlines) in <i>NUAK-/-</i> (J) are rescued upon the reintroduction of full length <i>NUAK cDNA</i> in muscle tissue (<i>NUAK-/-; mef2>NUAK</i>) (K). Expression of a V5-tagged Stv protein rescues <i>NUAK-/-</i> phenotypes (L), while overexpression of CG14207-V5 fails to rescue (M). …”

The human T-cell development is altered in HTLV-1-infected HIS Rag2^-/-γ_c^-/- mice. by Julien Villaudy (40472)

“…The graphs present the mean and the SD. Statistical differences were calculated using the χ2 test: *P<0.05, **P<0.01. …”

Transcript levels of dsRNA-treated sporocysts 7 days after dsRNA exposure. by Marina de Moraes Mourão (189239)

“…For each dsRNA tested, data are represented as mean fold-differences (+/−S.E.) relative to the GFP control (1.00). …”

Effects of aldesleukin on effector T cell number, phenotypes, and proliferation. by John A. Todd (5933)

“…(C and D) There was increased pSTAT5 in mTeffs (mTeff pSTAT5 MFI = 7, SE = 0.3, range 4–13, <i>n</i> = 36). …”

Mutations in Rac1-Y64 changed binding to GTP. by Fumin Chang (193521)

“…Western blots were scanned and Rac1 activity was normalized to the total cellular Rac1. Data shown are mean values±SEM. * denotes p < 0.02. (C) Protein lysates were harvested from MEF (lane 1) or MEF that were transfected with EGFP-Rac1WT (lane 2), EGFP-Rac1-61L (lane 3), EGFP-Rac1-61L/64F (lane 4), or EGFP-Rac1-61L/64D (lane 5). …”

Data_Sheet_1_Efficacy and safety of recanalization therapy for acute ischemic stroke with COVID-19: A systematic review and meta-analysis.PDF by Zilan Wang (8353569)

“…COVID-19 positive patients had significantly lower rates of functional independence at discharge [odds ratio (OR) 0.30, 95% confidence interval (CI) 0.15 to 0.59, P = 0.001], lower rates of successful recanalization (OR 0.40, 95% CI 0.24 to 0.68, P = 0.001), longer length of hospital stay (weighted mean difference 5.09, 95% CI 1.25 to 8.94, P = 0.009) and higher mortality rates (OR 3.38, 95% CI 2.43 to 4.70, P < 0.0001). …”

<i>S</i>. <i>aureus</i>–secreted citrate is sensed by <i>P</i>. <i>aeruginosa</i>. by Tiffany M. Zarrella (12902741)

“…<i>aureus</i> that increase or decrease induction in <i>P</i>. <i>aeruginosa</i>. …”

Cbf11 protein expression and defects of <i>Δcbf11</i> cells are diminished in minimal medium. by Martin Převorovský (209870)

“…<b>(G)</b> Western blot detection of Cbf11-TAP in cell extracts from panel F (lanes 5–6, 3–4) showing decreased Cbf11 protein amounts in cells grown in EMM as compared to YES. …”

DataSheet1_Effectiveness of prophylactic antibacterial drugs for patients with liver cirrhosis and upper gastrointestinal bleeding: a systematic review and meta-analysis.pdf by Zhuo Wang (18668)

“…Summing up the relevant data, the dichotomous variable was statistically analysed using the relative risk (RR) value and its 95% confidence interval (CI) and the continuous variable using the mean difference (MD) value and its 95% CI. All analyses were performed using Revman 5.4 software. …”

Data_Sheet_1_The efficacy and safety of isotonic and hypotonic fluids in intravenous maintenance fluid therapy in term newborns: national multicenter observational “neofluid” study... by Hasan Ozkan (6808268)

“…The primary outcomes were the change in mean plasma sodium (pNa) levels per hour (∆pNa mmol/L/h), the incidence of hyponatremia (pNa <135 mmol/L) and hypernatremia (pNa >145 mmol/L), and the occurrence of clinically significant changes in sodium levels (∆pNa >0.5 mmol/L/h).…”

Table_1_Does aerobic exercise reduce NASH and liver fibrosis in patients with non-alcoholic fatty liver disease? A systematic literature review and meta-analysis.xlsx by Veera Houttu (14048580)

“…Compared to controls, MICT resulted in a mean difference (MD) in the NAFLD biomarkers alanine transaminase (ALT) and aspartate aminotransferase (AST) of -3.59 (CI: -5.60, -1.59, p<0.001) and -4.05 (CI: -6.39, -1.71, p<0.001), respectively. …”

The population growth rate Λ_<i>P</i> is dependent on noise in single cell growth rate <i>σ</i>_λ, the division asymmetry <i>x</i> and the size control strategy... by Felix Barber (11001991)

“…Error bars in (A-C) show the standard error of the mean.</p>…”

Data_Sheet_1_The efficacy and safety of isotonic and hypotonic fluids in intravenous maintenance fluid therapy in term newborns: national multicenter observational “neofluid” study... by Hasan Ozkan (6808268)

“…The primary outcomes were the change in mean plasma sodium (pNa) levels per hour (∆pNa mmol/L/h), the incidence of hyponatremia (pNa <135 mmol/L) and hypernatremia (pNa >145 mmol/L), and the occurrence of clinically significant changes in sodium levels (∆pNa >0.5 mmol/L/h).…”

Predictors of long term weight loss maintenance in patients at high risk of type 2 diabetes participating in a lifestyle intervention program in primary health care: The DE-PLAN st... by Aleksandra Gilis-Januszewska (2951340)

“…Out of 105 patients who completed all three examinations (baseline age 56.6 (standard deviation (SD) = 10.7), body mass index 31.1 kg/m² (SD = 4.9), FINDRISC 18.6 (SD = 3.1)), 73 patients (70%) showed weight loss during the intervention (mean weight loss 4.2 kg, SD = 5.1). The total weight loss achieved in the maintainers (27 of 73 study participants) two years after the intervention had finished was 6.54 kg (4.47 kg+2.0 kg). …”

<i>trx</i> regulates <i>tan</i> expression and is involved in female abdominal pigmentation and its plasticity. by Jean-Michel Gibert (68707)

“…<i>trx</i> down-regulation induced a decrease in <i>tan</i> expression (t-test; *: p<0.05). …”

Data_Sheet_1_Reduced Expression of Prion Protein With Increased Interferon-β Fail to Limit Creutzfeldt-Jakob Disease Agent Replication in Differentiating Neuronal Cells.docx by Gerard Aguilar (12104756)

“…High titers of CJD agent also induced dramatic decreases in host PrP, a protein needed for productive agent replication. …”

Image1_Effects of winter pulsed warming and snowmelt on soil nitrogen cycling in agricultural soils: A lysimeter study.JPEG by Danielle Green (522450)

“…We monitored the subsurface soil temperature, moisture, and porewater geochemistry together with air temperature, precipitation, and N₂O fluxes in four agricultural field-controlled lysimeter systems (surface area of 1 m² and depth of 1.5 m) at the University of Guelph’s Elora Research Station over one winter (December 2020 to April 2021). …”