Fig 5 - by Mykola Pinkevych (125551)

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Different Association of Human Papillomavirus 16 Variants with Early and Late Presentation of Cervical Cancer by Ana Alfaro (280118)

“…Remarkably, this risk was higher for ACC (OR = 6.0, 95% CI = 1.1–33, p < 0.05) than for SCC (OR = 2.8, 95% CI = 1.3–5.9, p < 0.01). Interestingly, when analyzing only the HPV16-positive CC, D2 increases (OR = 2.5, 95% CI = 1.2–5, p < 0.05) and D3 decreases (OR = 0.45, 95% CI 0.2–0.9, p < 0.05) the risk to develop CC before 50 years old in relation with A1/2 variant. …”

Effects of specific anti-miRs for the five miRNAss on the IC50 of cisplatin (A) and paclitaxel (B) in Hec1A cells. by Taek Sang Lee (494682)

Ulk2 morphants have a decreased extension/retraction ratio. by Stacey Lee (647217)

Activation curves of nodes of the model compared with pharmacokinetics of Meth. by Abolhassan Behrouzvaziri (741985)

Changes in the body temperature evoked by methamphetamine after two doses of SB-334867. by Abolhassan Behrouzvaziri (741985)

Intracellular K⁺ decreases during pectoral fin bud growth. by Xiaowen Jiang (8291814)

Comparison of experimental data and model responses. by Abolhassan Behrouzvaziri (741985)

cART up-regulated iNOS and TNF-α in HIV-Tg rats—Blockade by Mg. by Lama ElZohary (6250859)

Temporal distributions of inscriptions and occupations using uniform 50-years-long timeblocks. by Vojtěch Kaše (6156971)

Resveratrol decreases cell proliferation in a time and dose dependent manner. by Mehtap Kilic Eren (591048)

Development of a cAMP sensor with decreased pH sensitivity. by Katy L. Everett (461878)

Body temperature changes induced by methamphetamine in rats pretreated with different doses of SB-334867. by Abolhassan Behrouzvaziri (741985)

Values of parameters of the model, which were considered not affected by SB (adapted from [30]). by Abolhassan Behrouzvaziri (741985)

Effect of SB-334867 on stress-induced body temperature increase associated with i.p. injections (n = 24–26 per group). by Abolhassan Behrouzvaziri (741985)

Reduced model and effect of inhibitory failure on the response. by Abolhassan Behrouzvaziri (741985)

Schematic of the model neuronal circuitry involved in responses to methamphetamine. by Abolhassan Behrouzvaziri (741985)

Parameter estimates generated by Monte-Carlo simulations. by Abolhassan Behrouzvaziri (741985)

Interpretation of HD sensitization as a change of inhibitory tone to the HD. by Abolhassan Behrouzvaziri (741985)