<i>In Vivo</i> Substrates of the Lens Molecular Chaperones αA-Crystallin and αB-Crystallin by Usha P. Andley (354477)

“…The amount of degraded glutamate dehydrogenase, α-enolase, and cytochrome c increased more than 50-fold in homozygous αA-R49C mutant lenses. In αB-R120G mouse lenses, our analyses identified decreased abundance of phosphoglycerate mutase, several β- and γ-crystallins, and degradation of αA- and αB-crystallin early in cataract development. …”

Data_Sheet_1_Middle Cerebellar Peduncle Width—A Novel MRI Biomarker for FXTAS?.PDF by Annie L. Shelton (5445332)

“…<p>Fragile X-associated tremor/ataxia syndrome (FXTAS) is a severe neurodegenerative movement disorder affecting over 40% of male and 16% of female FMR1 premutation carriers over the age of 50. …”

<i>CDKN3</i> mRNA as a Biomarker for Survival and Therapeutic Target in Cervical Cancer by Eira Valeria Barrón (796117)

“…<i>CDKN3</i> mRNA was on average 6.4-fold higher in tumors than in controls (p = 8 x 10⁻⁶, Mann-Whitney). A total of 68.2% of CC patients over expressing <i>CDKN3</i> gene (fold change ≥ 17) died within two years of diagnosis, independent of the clinical stage and HPV type (Hazard Ratio = 5.0, 95% CI: 2.5–10, p = 3.3 x 10⁻⁶, Cox proportional-hazards regression). …”

Image 1_Distinct brain and neurocognitive transformations after bariatric surgery: a pilot study.jpeg by Bhaswati Roy (2802559)

“…At six months, we observed reversal of brain alterations for most patients and a concomitant rebound of cognitive scores to patient’s baseline status.…”

Transmission of tuberculosis in rural Henan, China: a prospective population-based genomic spatial epidemiological study by Zhuo Quan (17658835)

“…The clustering risk decreased rapidly with increasing distances between patient residences, but 77.6% of clustered patient pairs lived ≥5.0 km apart. …”

Weak Compliance Undermines the Success of No-Take Zones in a Large Government-Controlled Marine Protected Area by Stuart J. Campbell (115219)

“…These declines in fish biomass were not driven by changes in habitat quality; coral cover increased in all zones, possibly as a result of a shift in fishing gears from those which can damage reefs (i.e., nets) to those which cause little direct damage (i.e., handlines and spears). …”

Ca²⁺ signalling and mitochondrial physiology defects in cells lacking anxA6. by Marcin Chlystun (288876)

“…(C) ΔΨm in <i>AnxA6</i>^+/+ and <i>AnxA6</i>^−/− ear fibroblasts was measured in cells equilibrated with 50 nM TMRM under resting conditions. …”

Sensitivity of various GFP insertion constructs (<i>columns A through J</i>) to protein misfolding. by Stéphanie Cabantous (92574)

“…<p>(A) Images of <i>E. coli</i> cells on plates expressing four test fusions proteins with decreasing folding robustness at 37°C. …”

Impaired bone formation in <i>Col1a1-Krm2</i> transgenic mice. by Jochen Schulze (365258)

“…<p>(A) Toluidine blue staining of non-decalcified vertebral body sections from 6 weeks old female wildtype and <i>Col1a1-Krm2</i> transgenic littermates revealing that the normal appearance of cuboidal osteoblasts (arrows) covering trabecular bone surfaces is only observed in wildtype controls (scale bars, 50 µm). …”

Dynamic profiles of the prototypic integrated system under different conditions, and a comparison to the kinetic-based model. by Jong Min Lee (271984)

“…<p>The concentration of carbon and amount of biomass within the cellular system over a simulation time of 10 h is illustrated. The decreasing lines represent the concentration of carbon (as indicated by the left <i>y</i>-axis), which is being consumed, in the system. …”

dAβ expression alters memory only when associated with APPL partial loss-of-function. by Isabelle Bourdet (783402)

Increased sediment load during a large-scale dam removal changes nearshore subtidal communities by Stephen P. Rubin (4672648)

“…Macroalgae, predominantly kelp and foliose red algae, were abundant before dam removal with combined cover levels greater than 50%. Where persistent sediment deposits formed, macroalgae decreased greatly or were eliminated. …”

Supplementary Information Files for 'The influence of climate change on the restoration trajectory of a nutrient-rich deep lake' by Alan D Radbourne (7534406)

“…This is of growing importance for many such lakes, given widespread climate-driven lengthening of stratification and a national trend of decreasing summer rainfall (decreasing seasonal flushing) but more intense summer storm events (resulting in short-term flushing events).…”

Deletion of <i>Wt1</i> during early gonadogenesis has a great impact on ovarian morphogenesis. by Alejo Torres-Cano (12878169)

“…Decreased CDH1 and RALDH2 expression was observed in the OE of <i>Wt1</i>^{<i>LoxP/GFP</i>}<i>;Wt1</i>^<i>Cre</i> P5 mice. …”

Data_Sheet_1_Sense of agency at a gaze-contingent display with jittery temporal delay.docx by Junhui Kim (18575083)

“…We manipulated the delay between eye movements and display updates using a truncated normal distribution (μ to μ + 2 σ) with μ ranging from 0 to 400 ms and σ fixed at 50 ms. …”

Dynamin inhibition by dynasore affects LTP, a type of synaptic plasticity due to sustained activity in hippocampus. by Mauro Fà (59065)

“…<p><b>A</b>, Dynasore (80 μM, 20 minute perfusion, open triangles) decreases LTP induced by theta-burst stimulation in CA₃–CA₁ synapses compared to vehicle-treated slices (black circles)(F_1,10 = 9.081, <i>p</i> = 0.013). …”

Table_1_Lactate Dehydrogenase as a Potential Therapeutic Drug Target to Control Babesia bigemina.docx by Lan He (219448)

“…Gossypol has a significant (P < 0.0001) inhibitory effect on the in vitro growth of B. bigemina, with IC₅₀ of 43.97 mM after 72 h of treatment. …”

Image_1_Lactate Dehydrogenase as a Potential Therapeutic Drug Target to Control Babesia bigemina.tif by Lan He (219448)

“…Gossypol has a significant (P < 0.0001) inhibitory effect on the in vitro growth of B. bigemina, with IC₅₀ of 43.97 mM after 72 h of treatment. …”

Spatial Distribution and Temporal Patterns of Cassin’s Auklet Foraging and Their Euphausiid Prey in a Variable Ocean Environment by Suzanne Manugian (832981)

“…<div><p>Krill (<i>Euphausiids)</i> play a vital ecosystem role in many of the world’s most productive marine regions, providing an important trophic linkage. …”

Data_Sheet_1_The APSES Gene MrStuA Regulates Sporulation in Metarhizium robertsii.DOC by Wenjing Yang (466552)

“…We also show that the median lethal time (LT₅₀) of the mutant increased by 19%. This increase corresponded with a slower growth rate and an earlier conidia germination time compared to that of the wild strain. …”