Image 6_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Image 5_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mi... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 1_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

Data Sheet 4_Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture... by Vaskar Das (21529538)

“…EC₅₀ estimates for (2R,6R)-Hydroxynorketamine were 14.2 mg/kg (95% CI: 10.3 mg/kg to 19.7 mg/kg) in male and 16.9 mg/kg (95% CI: 12.8 mg/kg to 22.3 mg/kg) in female mice (P < 0.637). (2R,6R)-Hydroxynorketamine plus meloxicam enhanced the analgesic effect on the AUC_0−3d of meloxicam alone. (2R,6R)-Hydroxynorketamine analgesia was associated with increases in Glutamate receptor A1 & A2, p-Kv2.1, p-CaMKII and reduced BDNF protein ratios in the hippocampus, attenuated c-Fos in the spinal cord, and decreased BDNF at the dorsal root ganglion (DRG).…”

SAUR63 interactions with PP2C.D proteins. by Punita Nagpal (185838)

HNSCC cell lines (FaDu and Hep2) were treated with DSF at the indicated concentrations (0.5–5 μM) and cell viability was measured by CCK-8 assay. by Young Min Park (101809)

“…<p>A) Degradation of cell viability by DSF was found to be dependent on copper. B) A marked decrease in viability mediated by DSF was noted at 1 μg/mL concentration in FaDu cells and at 0.5 μg/mL in Hep2 cells. …”

Effects of RSV on liver weight, liver index and histological changes in HFD rats. by Hui Yang (91136)

Rapid degeneration of 5-HT neurons in SERT-Cre^cre/wt Munc18-1^lox/lox mice. by Jacobus J. Dudok (338648)

“…(O) Analysis of the number of 5-HT cell bodies in the sections showed that there is no difference at E16, but at E18 and P2 there is a decrease of 80% to 90% in the number of 5-HT cell bodies in SERT-Cre^cre/wt Munc18-1^lox/lox sections. …”

Gating properties of <i>CACNA1I</i> variants with pooled WT data. by Yousra El Ghaleb (22075892)

The technical route of the study. by Hongliang Zou (20707270)

“…The highest root-mean-square error recorded was 2.72m in five sequences from a multi-modal multi-scene ground robot dataset, which was significantly lower than competing approaches. …”

Point cloud fusion instance effect. by Hongliang Zou (20707270)

“…The highest root-mean-square error recorded was 2.72m in five sequences from a multi-modal multi-scene ground robot dataset, which was significantly lower than competing approaches. …”

Experimental results in the SubT-MRS dataset. by Hongliang Zou (20707270)

“…The highest root-mean-square error recorded was 2.72m in five sequences from a multi-modal multi-scene ground robot dataset, which was significantly lower than competing approaches. …”

PSD curves of cells at different densities. by Mingkun Pang (11873753)

Influence of the order of addition of fusing partners on HCVpp 1a fusion inhibition by Arb. by Elodie Teissier (232354)

“…a<p>Arb (11.3 µM) was pre-incubated sequentially with either HCVpp or R₁₈-labeled liposomes or both for the indicated times at 37°C before initiating lipid mixing by decreasing pH to 5.0 as described in the legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015874#pone-0015874-g002" target="_blank">Figure 2</a>. …”

Repeated injection of GdCl₃ attenuates <i>S</i>. <i>japonicum</i> egg-induced hepatic granuloma inflammation. by Shengsheng Zheng (789770)

Repeated injection of GdCl₃ reduced egg-induced hepatic fibrogenesis. by Shengsheng Zheng (789770)

Effect of GdCl₃ treatment on expression of IL-13Rα2 and CD68 in egg-induced hepatic granuloma. by Shengsheng Zheng (789770)

Comparison of crude birth rate (CBR, live births per 1,000 population) predicted using the D5+/D20+ ratio and Bocquet-Appel’s [12] P index in 63 Mesolithic and Neolithic skeletal s... by Patrik Galeta (16015459)

Analysis of hematological parameters in eight treatments at the end of the growth experiment and after bacterial challenge. by Razia Liaqat (17873634)

5-FU blocks cell cycle progression in G1 phase. by Marcelo de Carvalho Filgueiras (408321)

“…(<b>H</b>) Cell sorter analysis revealed that the population of cells in the S and G2 phase was remarkably decreased by 5-FU. Values were represented as the means ± standard deviation.…”