Nausea-free days up to day 10. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

Baseline characteristics of the patients^a. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

Flow of patients in Halos trial. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

Cough-free days up to day 10. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

Dyspnea-free days up to day 10. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agents by Anastasia Hyrina (3860455)

“…Pre-treatment of Huh-7.5.1 cells with PF-429242 results in a dose-dependent inhibition of DENV infection [median inhibitory dose (EC₅₀) = 1.2 microM; median cytotoxic dose (CC₅₀) = 81 microM; selectivity index (SI) = 68)] and a ~3-log decrease in DENV-2 titer with 20 microM of PF-429242. …”

Whole mount in situ hybridization (WISH) for <i>atp6v1e1</i> ohnologs in zebrafish embryos. by Lore Pottie (10994479)

“…Gene expression levels of <i>atp6v1e1b</i> remained normal. Data are expressed as mean ± SD from 5 biological replicates. 2-way ANOVA with Tukey test for multiple comparison. …”

Knock-out of <i>atp6v1e1b</i> in zebrafish shows an early phenotypic read-out. by Lore Pottie (10994479)

“…Data are expressed as mean ± SD from 5 biological replicates. (C) Band intensities of fluorescence signals of atp6v1e1 and α-tubulin were quantified and normalized to the corresponding WT controls. …”

Influences of parabolic flight on activity and heart rate. by Peiliang Wang (753153)

DataSheet1_Development, growth and metabolic effects in stage IV lobster (Homarus americanus) following chronic exposure to sediments spiked with commercial formulations of deltame... by Dounia Daoud (7883006)

Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment-3 by Iliya Lefterov (73826)

“…</p><p></p>r vehicle for 18 h prior to LPS treatment (50 ng/ml). Control cells received vehicle only (veh). …”

Impact of radiation on bone marrow is dose dependent. by Tien T. Tang (3615287)

“…<p>Graph of mean standard uptake value of ¹⁸F-FDG in the bone marrow with significant decrease in activity in 7.5 Gy whole body irradiated group compared to sham group 5 days post radiation exposure. …”

Clustering analysis of the top 300 ranked probe sets from the five methods. by Mary-Lee Dequéant (271208)

Characterization of passage 1 (P1) bone marrow-derived canine mesenchymal stromal cells (cMSCs). by Melissa A. MacIver (12850566)

Mobile phone mobility index (MPMI) values by week in Korea in 2020. by Ye Ji Lee (11055903)

The Strong <i>In Vivo</i> Anti-Tumor Effect of the UIC2 Monoclonal Antibody Is the Combined Result of Pgp Inhibition and Antibody Dependent Cell-Mediated Cytotoxicity by Gábor Szalóki (631712)

“…However, this inhibition is partial, since UIC2 binds only to 10–40% of cell surface Pgps, while the rest becomes accessible to this antibody only in the presence of certain substrates or modulators (e.g. cyclosporine A (CsA)). The combined addition of UIC2 and 10 times lower concentrations of CsA than what is necessary for Pgp inhibition when the modulator is applied alone, decreased the EC₅₀ of doxorubicin (DOX) in KB-V1 (Pgp⁺) cells <i>in vitro</i> almost to the level of KB-3-1 (Pgp^-) cells. …”

Select genes are co-regulated by NSL and RbBP5-MLL complexes. by Xiaoming Zhao (484793)

“…</b> Alteration of global histone H4 or H3K4 modifications in hMOF, hNSL1, hRbBP5 or hMSL3L1 siRNA knockdown HeLa cells. HeLa cells were transfected with indicated siRNAs (non-targeting siRNA as control). …”

Curve of superficial area with Δσ[21]. by Fan Zhang (46132)

Thymol and its combination with classical anthelmintics. by Guillermina Hernando (553795)

Screening for cell culture grown HCV genotype 1a (clone H77) infectivity in the presence of vaccine sera. by Keith Meyer (309742)

“…Neutralizing sera are those which display ≥50% decrease in FFU at a dilution of ≥1∶20 (panel A). …”