Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Here, by addressing a high-energy water, we improved the IC₅₀ value of our co-crystallized glycogen synthase kinase-3β (GSK-3β) inhibitor by nearly two orders of magnitude. …”

Twenty-two identified and replicated loci and their overlap with associations to metabolic traits and clinical phenotypes. by Johannes Raffler (793347)

“…<p>^a SNP with the strongest association to targeted metabolic traits (“lead SNP”)</p><p>^b SNP with the strongest association to non-targeted metabolic traits</p><p>^c manually added to the list of most plausible candidate genes derived by evidence-based selection</p><p>^d additional candidates match to other non-targeted traits that also associate with the lead SNP</p><p>^e results from GWAS (<i>P</i> < 5.0×10⁻⁸)</p><p>^f mutations determined in clinical studies</p><p>For each locus, we selected all variants that displayed genome-wide significant association signals to metabolic traits in the SHIP-0 cohort. …”

Combined EGCG/As decreases the viability of two types of EC, HUVEC and HBMEC. by Jee-Youn Kim (796526)

miR-275 and miR-305 maternal loss-of-function mutants exhibited impaired flight capability, decreased hatching rate and survival rate. by Junfei Xie (3148638)

Maps of median projected λ_<i>S</i> (a) and <i>R</i>₀ (b) across 1st-level sub-national administrative regions in selected South American countries. by Keith Fraser (1868587)

Evaluation of the Acid Baking Technique to Decrease the Phosphorus Content of the Iron Ore by Leonardo Martins da Silva (7425692)

Decrease in the number of prescriptions for antibiotics in percentage, by studies assessing this outcome parameter. by Christin Löffler (3539528)

Visual deprivation rescues the decrease in proliferative cells by HDAC1 knockdown. by Yi Tao (178829)

Apigenin decrease eosinophil infiltration in colonic tissues from HFD-mice. by Daniela Gentile (5089280)

Portfolios with different number of securities involved in E(r) – risk system. by Mihály Ormos (697939)

Longitudinal Lung Function Decrease in Subjects with Spontaneous Healed Pulmonary Tuberculosis by Seung Heon Lee (713097)

“…<div><p>Objective</p><p>We compared the longitudinal course of post-bronchodilator Forced Expiratory Volume in 1 second (pFEV1) over a 10-year period in subjects with spontaneous healed pulmonary tuberculosis (SHPTB) with that in normal subjects.…”

Inhibition of Rac1 decreases lamellipodia formation and increases endothelial permeability. by Jerome W. Breslin (548352)

Inhibition of AhR signaling decreases growth of prostate cancer cells. by Oliver Richmond (585233)

The number of motor neurons is decreased in old Gas7-deficient mice. by Bo-Tsang Huang (162584)

Lipoprotein and albumin-depleted serum decreases colony-spreading stimulatory activity. by Yosuke Omae (230962)

Large state-wide variation (8.6-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2018 ^a indicates ≥1.50 SD (17.9) from the mean (32.9... by Luke R. Cavanah (19022435)

Large state-wide variation (11.1-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2015 ^a indicates ≥1.50 SD (20.2) from the mean (36.... by Luke R. Cavanah (19022435)

Large state-wide variation (8.6-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2017 ^a indicates ≥1.50 SD (18.0) from the mean (33.1... by Luke R. Cavanah (19022435)

Large state-wide variation (8.5-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2019 ^a indicates ≥1.50 SD (16.8) from the mean (31.0... by Luke R. Cavanah (19022435)

Large state-wide variation (8.6-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2020 ^a indicates ≥1.50 SD (16.0) from the mean (29.9... by Luke R. Cavanah (19022435)