DataSheet_1_High expression of RARG accelerates ovarian cancer progression by regulating cell proliferation.zip by Lin Xiu (11085656)

“…The area under the curve (AUC) of RAGR expression for predicting patient survival rates at 1, 5 and 9 years were 0.659, 0.616 and 0.627, respectively. …”

Image_3_Blockade of growth hormone receptor signaling by using pegvisomant: A functional therapeutic strategy in hepatocellular carcinoma.tif by Ahmed O. Kaseb (11654188)

“…Mechanistically, pegvisomant decreased the phosphorylation of GHR downstream survival proteins including JAK2, STAT3, STAT5, IRS-1, AKT, ERK, and IGF-IR. …”

Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis by Li Ma (46633)

“…From a large USDA dairy cattle pedigree with over half a million genotyped animals, we extracted 186,927 three-generation families, identified over 8.5 million maternal and paternal recombination events, and constructed sex-specific recombination maps for 59,309 autosomal SNPs. …”

Image_1_Dietary patterns suggest that dark chocolate intake may have an inhibitory effect on oral cancer: a Mendelian randomization study.jpeg by Hongwei Wang (151141)

“…We extracted 21 dietary exposures, including 10 dietary patterns, 6 vitamins, and 5 micronutrients, from the UK Biobank database, using the inverse variance weighting method as the primary statistical method. …”

Image_6_Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.tif by Hongmei Li-Byarlay (5227208)

“…Contrasts of gene expression and 5 mC DNA methylation profiles between IAPV-infected and control individuals at these time points – corresponding to the pre-replicative (5 h), replicative (20 h), and terminal (48 h) phase of infection – indicate that profound immune responses and distinct manipulation of host molecular processes accompany the lethal progression of this virus. …”

Table_7_Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.XLSX by Hongmei Li-Byarlay (5227208)

“…Contrasts of gene expression and 5 mC DNA methylation profiles between IAPV-infected and control individuals at these time points – corresponding to the pre-replicative (5 h), replicative (20 h), and terminal (48 h) phase of infection – indicate that profound immune responses and distinct manipulation of host molecular processes accompany the lethal progression of this virus. …”

Image_6_Autophagy-Related LC3 Accumulation Interacted Directly With LIR Containing RIPK1 and RIPK3, Stimulating Necroptosis in Hypoxic Cardiomyocytes.TIF by Yao Huang (216100)

“…Conversely, after alleviating hypoxia-induced autophagic flux impairment with LC3 or ATG5 knockdown adenovirus, the effects of hypoxia on RIPK1 and RIPK3 levels were reduced, which resulted in decreased p-RIPK3 and p-MLKL. …”

Image_2_A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.tif by Jinglei Xiao (1422004)

“…Left shift of Na_V activation around a value of 5.5 mV in the thalamocortical models suppressed normal bursting of thalamocortical (TC) cells by triggering its chaotic oscillations. …”

Data_Sheet_1_The Effects of Exercise on Appetite in Older Adults: A Systematic Review and Meta-Analysis.docx by Sarah Hubner (11724173)

“…Standardized mean difference summary statistics (Hedge's g effect sizes) and 95% confidence intervals were reported.</p><p>Results: We identified 15 reports (13 studies) which met all inclusion criteria (5 resistance training, 3 aerobic, 6 mixed modalities). …”

Data_Sheet_1_Revisiting the complex time-varying effect of non-pharmaceutical interventions on COVID-19 transmission in the United States.docx by Gonghua Wu (14821738)

“…</p>Results<p>We found that (i) the empirical reduction in reproduction number attributable to integrated NPIs was 52.0% (95%CI: 44.4, 58.5%) by August and September 2020, whereas the reduction continuously decreased due to the relaxation of NPIs in following months; (ii) international travel restrictions, stay-at-home requirements, and restrictions on gathering size were important NPIs with the relative contribution higher than 12.5%; (iii) vaccination alone could not mitigate transmission when the fully vaccination coverage was less than 60%, but it could effectively synergize with NPIs; (iv) even with fully vaccination coverage >60%, combined use of NPIs and vaccination failed to reduce the reproduction number below 1 in many states by February 2022 because of elimination of above NPIs, following with a resurgence of COVID-19 after March 2022.…”

DataSheet1_Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer.docx by Weina Xu (558990)

“…Additionally, immune infiltration, tumor mutational load (TMB), and drug sensitivity were evaluated. We validated the expression levels of prognostic genes. …”

Table 1_Increasing vulnerability of an endemic Mediterranean-climate conifer to changing climate and fire regime.docx by Frank W. Davis (8218293)

“…Ensembles of MAXENT and General Boosted Models were produced for a 2.1 million ha model domain encompassing BDF’s 672,000 ha range for the period 1981–2010, and were projected to 2040–2069 and 2070–2099 using three climate models (warmer-wetter, warmer, and hotter-drier) under a high emission scenario (IPCC 5th Assessment, RCP 8.5). Wildfire projections were analyzed only for mid-century based on warmer-wetter and hotter-drier climate scenarios. …”

Image_2_Dietary patterns suggest that dark chocolate intake may have an inhibitory effect on oral cancer: a Mendelian randomization study.jpeg by Hongwei Wang (151141)

“…We extracted 21 dietary exposures, including 10 dietary patterns, 6 vitamins, and 5 micronutrients, from the UK Biobank database, using the inverse variance weighting method as the primary statistical method. …”

Is the risk of progressive multifocal leukoencephalopathy the real reason for natalizumab discontinuation in patients with multiple sclerosis? by Julia Krämer (436881)

“…Despite introduction of the currently employed PML risk stratification algorithm, the incidence of natalizumab-associated PML cases is not decreasing.</p><p>Objectives</p><p>We addressed the following questions: How do natalizumab-treated multiple sclerosis patients and their treating physicians assess and deal with PML risk? …”

Image_1_Blockade of growth hormone receptor signaling by using pegvisomant: A functional therapeutic strategy in hepatocellular carcinoma.tif by Ahmed O. Kaseb (11654188)

“…Mechanistically, pegvisomant decreased the phosphorylation of GHR downstream survival proteins including JAK2, STAT3, STAT5, IRS-1, AKT, ERK, and IGF-IR. …”

Image_1_Dietary patterns suggest that dark chocolate intake may have an inhibitory effect on oral cancer: a Mendelian randomization study.jpeg by Hongwei Wang (151141)

“…We extracted 21 dietary exposures, including 10 dietary patterns, 6 vitamins, and 5 micronutrients, from the UK Biobank database, using the inverse variance weighting method as the primary statistical method. …”

Table_1_Dietary patterns suggest that dark chocolate intake may have an inhibitory effect on oral cancer: a Mendelian randomization study.xlsx by Hongwei Wang (151141)

“…We extracted 21 dietary exposures, including 10 dietary patterns, 6 vitamins, and 5 micronutrients, from the UK Biobank database, using the inverse variance weighting method as the primary statistical method. …”

Image_4_Blockade of growth hormone receptor signaling by using pegvisomant: A functional therapeutic strategy in hepatocellular carcinoma.tif by Ahmed O. Kaseb (11654188)

“…Mechanistically, pegvisomant decreased the phosphorylation of GHR downstream survival proteins including JAK2, STAT3, STAT5, IRS-1, AKT, ERK, and IGF-IR. …”

Data_Sheet_1_Impact of New-Onset Persistent Left Bundle Branch Block on Reverse Cardiac Remodeling and Clinical Outcomes After Transcatheter Aortic Valve Replacement.docx by Kyu Kim (3412583)

“…During a median follow-up of 18.1 months, the new LBBB group experienced a higher incidence of primary outcomes [hazard ratio (HR): 5.03; 95% confidence interval (CI): 2.60–9.73; p < 0.001] and all-cause death (HR: 2.80; 95% CI: 1.38–5.69; p = 0.003). …”

Alterations in Lipid and Inositol Metabolisms in Two Dopaminergic Disorders by Eva C. Schulte (213836)

“…</p><p>Results</p><p>After stringent quality control, we identified decreased levels of long-chain (polyunsaturated) fatty acids of individuals with PD compared to both RLS (PD vs. …”