Showing 14,321 - 14,340 results of 49,222 for search '(( 50 ((nn decrease) OR (a decrease)) ) OR ( 5 ((point decrease) OR (mean decrease)) ))', query time: 1.24s Refine Results
  1. 14321
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  5. 14325

    Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

    Published 2022
    “…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”
  6. 14326

    Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

    Published 2022
    “…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”
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  10. 14330

    The association of diabetic retinopathy with metabolic syndrome. by Lu Gao (44114)

    Published 2016
    “…When patients were grouped according to the number of detected components of the metabolic syndrome, the percentage of patients with DR increased linearly with the increasing number of components in their respective groups (14.3%, 38.9%, 49.1%, 61.4%, 83.3%, respectively), whereas, the percentage of patients without DR decreased with the increasing number of components (85.7%, 61.1%, 50.9%, 38.6%, 16.7%, respectively) (Pearson χ<sup>2</sup> = 9.938, P = 0.037). …”
  11. 14331

    The change in mean annual densities of Amakihi at mid-elevation due to the translocation of disease-resistant Amakihi as a function of larval carrying capacity and density of infec... by Peter H. F. Hobbelen (298146)

    Published 2013
    “…The other climate scenarios are derived from this scenario by increasing or decreasing the daily temperatures and rainfall. The mean annual temperatures and average yearly amounts of rainfall for these scenarios are 15.5°C and 3000 mm (t−), 18.5°C and 3000 mm (t+), 17°C and 2000 mm (r−) and 17°C and 4000 mm (r+). …”
  12. 14332
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  15. 14335

    <i>Ssdp</i> pan-neuronal knockdown affects adult brain development. by Safa Salim (9186786)

    Published 2023
    “…Each black dot is a data point representing an independent biological replicate with 20 individual fly heads per biological replicate. …”
  16. 14336

    <i>Ssdp</i> overexpression causes abnormalities in mitochondrial morphology and dynamics. by Safa Salim (9186786)

    Published 2023
    “…Horizontal red line represents the mean value. Each black dot is a data point representing an independent biological replicate. …”
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  18. 14338

    Scores of each variable in the main components. by Leila Vahdatiraad (17382718)

    Published 2023
    “…Stellate sturgeon (<i>Acipenser stellatus</i>) fry, was exposed to diazinon (25, 50, and 75% of 96h-LC<sub>50</sub>) for 6 days after pre-treatment with an HSP inducer (HSPi), TEX-OE<sup>®</sup> (a prickly pear cactus extract), for 4 hours. …”
  19. 14339

    Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth fact... by Bei Cao (141848)

    Published 2023
    “…Coadministration of itraconazole increased the AUC<sub>0-inf</sub> of limertinib by 289.8% (GLSM ratio, 389.8%; 90% CI, 334.07–454.82), but decreased that of CCB4580030 by 35.96% (GLSM ratio, 64.04%; 90% CI, 50.78–80.77).…”
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