An Allosteric Modulator of RNA Binding Targeting the N‑Terminal Domain of TDP-43 Yields Neuroprotective Properties by Niloufar Mollasalehi (9511076)

“…<i>In silico</i> docking of 50K compounds to the NTD domain of TDP-43 identified a small molecule (nTRD22) that is bound to the N-terminal domain. …”

The number of amyloid plaques and amount of Aβ_1-42 were reduced in S100A9 KO/Tg mice. by Hee Jin Kim (469168)

“…Sections are 4 µm thick. ((a) – (h) Scale bar; 200 µm, (i)-(l) scale bar; 50 µm). …”

MDS erythroid precursors are deficient in membrane lipid rafts. by Kathy L. McGraw (327439)

“…Enlarged images illustrate lipid rafts at 630x with 6-zoom magnification. Bars represent 5 µm. (B) Statistically significant decrease in the number of rafts per cell in MDS erythroid precursors compared to normal donor erythroid cells, graph represents mean ± SE. …”

Characterization of journals being listed in the DOAJ and their development over time (2011–2018). by Georg Richtig (4582933)

The conserved phenylalanine residue in PRMT5 is critical for inhibition by the five compounds. by Gui-Mei Kong (4353751)

“…D, The F225M mutation in PRMT5 decreased the IC₅₀ values of the compounds, as determined by quantitation and analysis of methylation assay results.…”

Antimicrobial activity of RP-1 peptide conjugate with ferrocene group by Natalia C. S. Costa (8626206)

“…In comparison with amphotericin B, a second-line drug approved for leishmaniasis treatment, (IC₅₀ = 0.63 μmol L^-1), Fc-RP1 was more active and showed a 2.5-fold higher selectivity index. …”

Characterization of journals being listed on Beall’s list and their development over time (2011–2018). by Georg Richtig (4582933)

ING1 is one of the miR-371-5p targets and negatively regulated by miR-371-5p. by De He (497662)

Effect of DM, and/or <i>M. charantia</i> on the immuno-expressional level of NGF protein in maternal cerebellar tissue of different groups. by Amoura M. Abou-El-Naga (21001524)

“…The values are expressed as the means±SEM of 5 microscopic fields/tissue samples of NGF immune-expression, **<i>P</i> < 0.01.…”

Flow cytometry analysis of the changes in T cell and B cell proportions in iNOS-KO and WT control rats. by Jia Shen (1828945)

Transition from scattered to smooth bell shaped distributions of <i>r_v</i> and <i>I</i> when grouping genes. by Masa Tsuchiya (78226)

“…<p>Distributions of (A) <i>r_v</i> and (B) <i>I</i> for ensembles of <i>n</i> randomly chosen genes from whole genomes (<i>n</i> = 10, 50, 100, 200, 500, 1000), estimated by Gaussian kernel with 100 repeats at a representative <i>t</i> = 48h (similar profiles are obtained for all time points), left panels for atRA and middle panels for DMSO response. …”

Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo by Er-Jun Hao (10097665)

“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC₅₀ = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”

Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo by Er-Jun Hao (10097665)

“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC₅₀ = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”

Correlation between total memory or naïve Tregs with PD1⁺ CD95⁺ cells. by Vedran Brezar (337452)

Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene <i>OsERF922</i> by Fujun Wang (96184)

“…Here, we report the improvement of rice blast resistance by engineering a CRISPR/Cas9 SSN (C-ERF922) targeting the <i>OsERF922</i> gene in rice. …”

A Randomized Clinical Trial to Evaluate Two Doses of an Intra-Articular Injection of LMWF-5A in Adults with Pain Due to Osteoarthritis of the Knee by David Bar-Or (518741)

Effect of DM, and/or <i>M. charantia</i> on the immuno-expressional level of GFAP protein in maternal cerebellar tissue of different groups. by Amoura M. Abou-El-Naga (21001524)

Skeletal abnormalities in <i>Slc35a3</i>^{<i>–/–</i>}mice. by Soichiro Saito (15285875)

At 20-30 hpf, zebrafish heart is morphologically a tube-like structure with a AV canal (AV) separating the atrium (A) and ventricle (V). by Juhyun Lee (449913)

“…A, atrium; V, ventricle.</p>…”

The influence of <i>PINK1</i> on <i>P</i>. <i>berghei</i> infection in <i>A</i>. <i>stephensi</i>. by Li Gao (131516)