RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity by Brandon L. Probst (727964)

“…Here, we characterized the in vitro antioxidant, anti-inflammatory, and anticancer activities of RTA 408, a novel AIM that is currently being evaluated in patients with advanced malignancies. …”

CI-regulated utilization of alternative carbon sources is vital for <i>C</i>. <i>albicans</i> commensalism in GI tract. by Xinhua Huang (1905940)

An Analysis of Porphyrin Molecular FlexibilityUse of Porphyrin Diacids by Beisong Cheng (2970567)

“…Molecular mechanics calculations, using a modified version of MM2(87) and a newly developed force field for porphyrin diacids, correctly predict that the flexibility of <i>meso</i>-tetraaryl porphyrin diacids decreases as the steric bulk of the peripheral substituents increases:  [H₄TPyP]²⁺ ≈ [H₄TPP]²⁺ > [H₄T-2,6-(OH)₂ PP]²⁺ ≈ [H₄T-2,6-F₂ PP]²⁺ > [H₄T-2,6-Cl₂ PP]²⁺ ≈ [H₄TMP]²⁺. …”

Quantification of immunohistochemical staining of oral myofibroblasts using an anti-Ki67 antibody. by Maria Adriana Skeff (670466)

Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schönlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registr... by Hiroyuki Komatsu (2292505)

“…The primary end-points comprised a 50% increase in serum creatinine (sCr) values or end-stage kidney disease. …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

BTC mining profitability (PnL%) for different evolutions of BTC network hash rate and BTCUSD price. by Małgorzata Jabłczyńska (14883347)

“…A negative monthly BTC hash rate change means decreasing the BTC network hash rate. The market value point describes the current state of market mining efficiency assuming the parameter outlined in the section Values of variables as of 2021/12/03. …”

The HMR C-terminus is required for HMR localization in proximity to centromeres and HP1a-bound chromatin. by Andrea Lukacs (3752956)

cART up-regulated iNOS and TNF-α in HIV-Tg rats—Blockade by Mg. by Lama ElZohary (6250859)

BTC mining profitability (PnL%) for different evolutions of BTC network hash rate and different levels of hardware cost. by Małgorzata Jabłczyńska (14883347)

“…A negative monthly BTC hash rate change means decreasing BTC network hash rate. Antminer S19J Pro is assumed as the most optimal mining machine and its point describes the current state of market mining efficiency assuming parameters outlined in section Values of variables as of 2021/12/03. …”

N⁶-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon blac... by Bin Han (45760)

“…We found that both of m⁶A modifications of pri-miRNA-126 and its binding with DGCR8 were decreased after CB treatment, which resulted in the reduction of mature miRNA-126 accompanied by accumulation of unprocessed pri-miRNA-126. …”

HIV-1 expression plus cART promoted hepatic expression of sterol regulatory element-binding protein-1 (SREBP-1)—Suppression by high Mg diet. by Lama ElZohary (6250859)

Enrichment of <i>Efnb1</i> and <i>Efnb2</i> mRNA in POMC neurons during postnatal development of glutamatergic inputs. by Manon Gervais (9708032)

Phenotypic characterization of the mutant. by Hui Zhang (7197)

cART raised plasma total triglyceride and total cholesterol levels in HIV-Tg rats—Attenuation by high Mg diet. by Lama ElZohary (6250859)

Loss of <i>Efnb1</i> in POMC-expressing progenitors causes glucose intolerance in males. by Manon Gervais (9708032)

BTC mining profitability (PnL%) for different evolutions of BTC network hash rate and different levels of energy prices. by Małgorzata Jabłczyńska (14883347)

“…A negative monthly BTC hash rate change means decreasing the BTC network hash rate. Minimal, CN, PL, and US define respectively minimal world energy price level, China, Poland, and US located mining profitability corresponding to the local energy price, provided that remaining parameters are equal. …”

Comparison of sensitivity and specificity of three diagnostic tests to detect <i>Schistosoma mansoni</i> infections in school children in Mwanza region, Tanzania by Antje Fuss (5675879)

“…It is well-known that the sensitivity of this parasitological method decreases when infection intensities are moderate to low, however. …”