Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…XZB108, selectively inhibited HDAC8 (IC₅₀ = 0.90 ± 0.014 μM), suggesting that it may be a promising nonhydroxamate HDAC8 inhibitor. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…XZB108, selectively inhibited HDAC8 (IC₅₀ = 0.90 ± 0.014 μM), suggesting that it may be a promising nonhydroxamate HDAC8 inhibitor. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…XZB108, selectively inhibited HDAC8 (IC₅₀ = 0.90 ± 0.014 μM), suggesting that it may be a promising nonhydroxamate HDAC8 inhibitor. …”

Cell motility depends on a QSF secreted by cells. by Laurent Golé (198154)

“…Cells were recorded during 50 min, 1.5 hours after cells were washed in a fresh HL5 medium. …”

SIRT3 overexpression increased mitochondrial biogenesis in ccRCC cells. by Young-Ran Gu (12822429)

Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments by Stefania Ferro (76724)

“…The inhibition of tyrosinase (Ty, EC 1.14.18.1) represents an efficient strategy of decreasing melanogenesis and skin hyperpigmentation. …”

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies by Brianna D. Mackie (9212677)

“…Its cell-permeable analogue <b>DC432</b> (IC₅₀ of 54 ± 4 nM) decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells. …”

Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes by Wipawee Wongchana (5367968)

“…A similar impact on IL-10 production was observed when Notch signaling was inhibited with a gamma-secretase inhibitor (GSI). …”

Effects of GSI treatment on MAPK, PI3K/AKT and NF-κB pathway activation in LPS/IC-activated macrophages. by Wipawee Wongchana (5367968)

“…The arrows indicate cells with decreased or no p50 nuclear translocation (green). …”

Liquid cultures in RPMI-1640. by Nicholas C. Schena (16541975)

The mitochondrial H⁺ gradient of hypothermic brain mitochondria is reduced relative to physiological temperature. by Matthew E. Pamenter (111599)

“…<p><b>(A)</b> Hypothermic (black circles) brain H⁺ flux and oxygen consumption are equally coupled but reduced in magnitude relative to at physiological temperature (open circles). <b>(B)</b> Percent decrease of mitochondrial respiration, and <b>(C)</b> mitochondrial membrane potential with step-wise addition of malonate. …”

Transcript and protein expression levels of IDE (A, C), PLAU (B, D), GSK-3β (E, G) and CDK5 (F, H) in MS and MS9II cells. by Yanlin Wang (110566)

“…Immunoblots and respective histograms showing marked increase in protein levels of GSK-3β (G) and CDK5 (H) in MS9II cells. The protein levels were normalized to the β-actin and the values from four different experiments are expressed as means ± SEM, *<i>p</i><0.05, **<i>p</i><0.01.…”

Metastatic tumor formation after an intracardiac injection of parental and FL cells. by Tomoyuki Nakano (169130)

Evaluation of Efficiency of Liposome-Entrapped Iridium(III) Complexes Inhibiting Tumor Growth In Vitro and In Vivo by Huiyan Hu (9376570)

“…Surprisingly, its liposome-entrapped complexes 3alip, 3blip, and 3clip on B16 cells showed strong cytotoxicity (IC₅₀ = 13.6 ± 2.8, 9.6 ± 1.1, and 18.9 ± 2.1 μM). …”

The effects of intrathecal AMD3100 on the production of neuropeptides and pro-inflammatory cytokines, and cellular adhesion molecules in the ipsilateral L3-L5 spinal cord segment o... by Xin Luo (428648)

Estimated numbers of people aged 65+ years living with dementia under various scenarios and difference to ageing-only scenario. by Binod Nepal (625271)

Fig 1 - by Gilda Cennamo (448296)

“…</b> Left eye of a patient (50 years-old female) with pitituary adenoma before surgery reveals a reduction of vessel density in SCP (A1), DCP (B1), RPC (C1) and an increase of FAZ area (D1) respect to healthy subject. …”

Characterization of the Thermally Induced Topochemical Solid-State Transformation of NH₄[N(CN)₂] into NCNC(NH₂)₂ by Means of X-ray and... by Bettina V. Lotsch (1467520)

Characterization of the Thermally Induced Topochemical Solid-State Transformation of NH₄[N(CN)₂] into NCNC(NH₂)₂ by Means of X-ray and... by Bettina V. Lotsch (1467520)

Image_5_Down-Regulation of Lnc-CYP7A1-1 Rejuvenates Aged Human Mesenchymal Stem Cells to Improve Their Efficacy for Heart Repair Through SYNE1.TIFF by Jun Dong (43792)