The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing by Les Dethlefsen (57795)

“…A companion paper in <em>PLoS Genetics</em> (see Huse et al., doi: <a href="http://dx.doi.org/10.1371/journal.pgen.1000255">10.1371/journal.pgen.1000255</a>) shows that the taxonomic information obtained with these methods is concordant. Pyrosequencing of the V6 and V3 variable regions identified 3,300–5,700 taxa that collectively accounted for over 99% of the variable region sequence tags that could be obtained from these samples. …”

Table 1_Prevalence and prognostic value of sarcopenia in patients with bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis.docx by Lei Zhang (38117)

“…The results of meta-analysis showed that the pooled prevalence of sarcopenia was estimated to be 49% (95% CI: 41% to 57%, I² = 95.3%, P < 0.001), which was based on a random-effects model. We observed that BC patients with sarcopenia had a worse OS (HR:1.64, 95% CI: 1.30 to 1.97, I² = 76.5%, P < 0.001} and CSS (HR:1.86, 95% CI: 1.45 to 2.27, I² = 0.0%, P < 0.001).…”

The Soluble Guanylate Cyclase Activator BAY 58-2667 Protects against Morbidity and Mortality in Endotoxic Shock by Recoupling Organ Systems by Benjamin Vandendriessche (451155)

“…The resulting heme-free sGC can be reactivated by the heme- and nitric oxide (NO)-independent sGC activator BAY 58-2667 (Cinaciguat). We report that late (+8 h) post-treatment with BAY 58-2667 in a mouse model can protect against lethal endotoxic shock. …”

Correlation of serum screening and neuroimaging studies: a comparative analysis for diagnostic evaluation of neurocysticercosis among people with epilepsy attending mental health c... by Charles Makasi (20363277)

“…</p><p dir="ltr"><b>Results:</b><b> </b>Our findings showed a sensitivity of 87.5%; [95%CI (76.7 – 98.3)] and specificity of 60.7%; [95%CI (44.8 – 76.7)]. …”

Image_7_OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.tif by Longwei Xu (655781)

“…</p>Methods<p>Eosinophil infiltration, ovalbumin (OVA)-specific Ig production, OX40 expression and inflammatory factor levels in the intestine and bone marrow (BM) were investigated to evaluate inflammation.</p>Results<p>We confirmed that OVA-challenged mice produced high levels of Ox40, Mbp, Ccl11, Il5, Il4, Il13, and Il6 mRNA and a low level of Ifng mRNA in the intestine. …”

Detection of Plasma Protease Activity Using Microsphere-Cytometry Assays with <i>E</i>. <i>coli</i> Derived Substrates: VWF Proteolysis by ADAMTS13 by Shobhit Gogia (740889)

“…In this proof of principle study, we demonstrate the utility of this substrate to measure metalloprotease ADAMTS13 activity. …”

Table 4_Impact of prior exposures on biomarkers of blast during military tactical training.xlsx by Zhaoyu Wang (3059889)

“…How prior mild TBI (mTBI) history interacts with low-level blast (LLB) exposure, however, remains unexplored, which we investigate in the present study, to identify interindividual biomarker changes from LLB exposures influenced by prior history of mTBI.…”

DataSheet_1_Concomitant use of interleukin-2 and tacrolimus suppresses follicular helper T cell proportion and exerts therapeutic effect against lupus nephritis in systemic lupus e... by Yutaro Nasa (18342558)

“…</p>Methods<p>Using a parent-into-F1 model, we investigated the effect of IL-2 plus tacrolimus on Treg and Tfh proportions and the therapeutic effect.…”

<b>Metabolic Improvements with Tirzepatide in Lipodystrophy: A Novel Option?</b> by Rasimcan Meral (5022425)

“…We have recently shown that glucagon-like peptide-1 agonists are associated with metabolic improvements in FPLD. …”

Image3_A Role of Caveolae in Trabecular Meshwork Mechanosensing and Contractile Tone.JPEG by Michael L. De Ieso (12254687)

“…We hypothesized that caveolae sequester/inhibit RhoA, to regulate trabecular meshwork (TM) mechanosensing and contractile tone. …”

Image_1_Acid-Sensing Ion Channel 1/Calpain1 Activation Impedes Macrophage ATP-Binding Cassette Protein A1-Mediated Cholesterol Efflux Induced by Extracellular Acidification.TIF by Yuan-Mei Wang (11530463)

“…</p>Results<p>We showed that extracellular acidification enhanced ASIC1 expression and translocation, promoted calpain1 expression and lipid accumulation, and decreased ABCA1 protein expression as well as ABCA1-mediated cholesterol efflux. …”

DataSheet1_Single-cell analysis reveals specific neuronal transition during mouse corticogenesis.PDF by Ziheng Zhou (9499076)

“…</p><p>Results: By analyzing the developmental trajectories with scRNA-seq datasets in mice, we identified a specific developmental sub-path contributed by a cell-population expressing both deep- and upper-layer neurons (DLNs and ULNs) specific markers, which occurred on E13.5 but was absent in adults. …”

Image_2_A Phylogenomic Study of Acanthamoeba polyphaga Draft Genome Sequences Suggests Genetic Exchanges With Giant Viruses.TIF by Nisrine Chelkha (5722937)

“…We identified a putative sequence trafficking between this Acanthamoeba species and giant viruses, with 366 genes best matching with viral genes. …”

Data_Sheet_1_Diet Modulates the High Sensitivity to Systemic Infection in Newborn Preterm Pigs.docx by Ole Bæk (7482194)

“…</p><p>Methods: Using preterm cesarean delivered pigs as models for preterm infants, we infused live Staphylococcus epidermidis (SE, 5 × 10⁹ colony forming units per kg) systemically 0–3 days after birth across five different experiments. …”

Image7_Child-Onset Cerebellar Ataxia Caused by Two Compound Heterozygous Variants in ADPRS Gene: A Case Report.TIF by Jiehui Ma (10792134)

“…</p><p>Conclusion: We present the first report of the existence of two compound heterozygous variants of ADPRS, which leads to CONDSIAS.…”

Effectiveness of a Simple Lymphoedema Treatment Regimen in Podoconiosis Management in Southern Ethiopia: One Year Follow-Up by Catherine Sikorski (236175)

“…The regimen appears ideal for scaling up to other endemic regions in Ethiopia and internationally. We recommend that further research in the area include analysis of cost-effectiveness of the regimen.…”

Evidence of the Giant Barocaloric Effect in the PVA-Slime System by Molecular Dynamics Simulations by Richard Javier Caraballo-Vivas (22113727)

Image_2_Coenzyme Q10 or Creatine Counteract Pravastatin-Induced Liver Redox Changes in Hypercholesterolemic Mice.JPEG by Ana C. Marques (149564)

“…We observed that pravastatin induced higher H₂O₂ production rate (40%), decreased activity of aconitase (28%), a superoxide-sensitive Krebs cycle enzyme, and increased susceptibility to Ca²⁺-induced MPT (32%) in liver mitochondria. …”

DataSheet_1_The Effect of COVID-19 on Mental Health and Wellbeing in a Representative Sample of Australian Adults.pdf by Amy Dawel (6155789)

“…Depression, anxiety, and psychological wellbeing were measured with well-validated scales (PHQ-9, GAD-7, WHO-5). Using linear regression, we tested for associations between mental health and exposure to COVID-19, impacts of COVID-19 on work and social functioning, and socio-demographic factors. …”

Table_1_Genome-Wide DNA Methylation Enhances Stemness in the Mechanical Selection of Tumor-Repopulating Cells.xlsx by Wei Huang (36889)

“…In 1-day, TRCs had the highest non-CG methylation rate indicating its strong stemness. We found that genes with continuously increasing or decreasing methylation like CREB5/ADAMTS6/LMX1A may also affect the TRC screening process. …”