DataSheet4_Sanqi Oral Solution Mitigates Proteinuria in Rat Passive Heymann Nephritis and Blocks Podocyte Apoptosis via Nrf2/HO-1 Pathway.ZIP by Xiaowan Wang (9704207)

“…Further studies showed that SQ treatment could significantly inhibit podocyte apoptosis in PHN rats and ADR-injured podocytes, and protein levels of Cleaved Caspase-3 or the ratio of Bax/Bcl-2 were significantly decreased with SQ treatment in vivo or in vitro. Moreover, we found that the nuclear factor erythroid 2–related factor-2/heme oxygenase 1 (Nrf2/HO-1) pathway mediated the anti-apoptosis effective of SQ in podocyte. …”

Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity by Catherine Angénieux (145933)

“…We provoked in mice strong thrombocytopenia followed by dramatic thrombocytosis characterized by a short period with a vast majority of reticulated platelets. …”

datasheet1_Synergetic Effect of rHDL and LXR Agonist on Reduction of Atherosclerosis in Mice.pdf by Emily E. Morin (4630543)

“…This is perhaps a consequence of the limited cholesterol efflux abilities of atheroma macrophages due to decreased expression of cholesterol transporters in advanced atheromas and following rHDL infusion treatment. …”

2D MnTe/rGO Hybrid Structure for Moisture Energy Harvesting by Partha Kumbhakar (9410332)

“…We used density functional theory (DFT) calculations to understand the system’s ability to transfer charge. …”

Table_9_Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis.xlsx by Jipeng Yan (8473710)

“…Notably, 5 optimal ASV-based microbial markers were identified as the diagnostic model of AL amyloidosis and the AUC value of the train set and the test set was 0.8549 (95% CI 0.7310-0.9789) and 0.8025 (95% CI 0.5771-1), respectively. …”

DataSheet_1_CD226 and TIGIT Cooperate in the Differentiation and Maturation of Human Tfh Cells.pdf by Motoko Yasutomi (12117864)

“…Here we show that CD226 signals promote the early phase of Tfh cell differentiation in humans. …”

Data Sheet 1_miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.pdf by Juanjuan Zhang (432819)

“…Colitis was induced with 2.5% DSS for 7 days; miR-223 agomir or NC was administered intraperitoneally on days 2–4. …”

Data_Sheet_1_Tle4z1 Facilitate the Male Sexual Differentiation of Chicken Embryos.doc by Chen Chen (6544)

“…</p>Results<p>It showed that Tle4z1 has significant male preference in embryonic day 4.5, such phenomenon persisted during the growth period of chicken embryos. …”

DataSheet_2_The harmful intestinal microbial community accumulates during DKD exacerbation and microbiome–metabolome combined validation in a mouse model.zip by Jin Shang (704634)

“…Objective<p>Diabetic kidney disease (DKD) is one of the most prevalent complications of diabetes mellitus (DM) and is associated with gut microbial dysbiosis. We aim to build a diagnostic model to aid clinical practice and uncover a crucial harmful microbial community that contributes to DKD pathogenesis and exacerbation.…”

Tropical fishes can benefit more from novel than familiar species interactions at their cold-range edges by Angus Mitchell (8391018)

“…</p><p dir="ltr">3. All five tropical fish species showed increased anti-predator behaviours and decreased bite rate at their novel temperate range compared to their native tropical and subtropical ranges. …”

Image_7_A Phylogenomic Study of Acanthamoeba polyphaga Draft Genome Sequences Suggests Genetic Exchanges With Giant Viruses.TIF by Nisrine Chelkha (5722937)

“…We identified a putative sequence trafficking between this Acanthamoeba species and giant viruses, with 366 genes best matching with viral genes. …”

DataSheet_1_Immunoregulatory effects of RGMb in gut inflammation.docx by Magdiel Pérez-Cruz (6422627)

“…Anti-RGMb mAb (9D1) treatment decreased IFN-γ and significantly increased IL-5 and IL-10 in the gut of the treated mice compared to the isotype control treated mice.…”

Table_7_Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis.xlsx by Jipeng Yan (8473710)

“…Notably, 5 optimal ASV-based microbial markers were identified as the diagnostic model of AL amyloidosis and the AUC value of the train set and the test set was 0.8549 (95% CI 0.7310-0.9789) and 0.8025 (95% CI 0.5771-1), respectively. …”

Downregulation of Protein Kinase CK2 Activity Facilitates Tumor Necrosis Factor-α-Mediated Chondrocyte Death through Apoptosis and Autophagy by Sung Won Lee (222509)

“…We first measured CK2 activity in articular chondrocytes of 6-, 21- and 30-month-old rats. …”

Image_1_Coenzyme Q10 or Creatine Counteract Pravastatin-Induced Liver Redox Changes in Hypercholesterolemic Mice.PDF by Ana C. Marques (149564)

“…We observed that pravastatin induced higher H₂O₂ production rate (40%), decreased activity of aconitase (28%), a superoxide-sensitive Krebs cycle enzyme, and increased susceptibility to Ca²⁺-induced MPT (32%) in liver mitochondria. …”

Table_6_Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis.xlsx by Jipeng Yan (8473710)

“…Notably, 5 optimal ASV-based microbial markers were identified as the diagnostic model of AL amyloidosis and the AUC value of the train set and the test set was 0.8549 (95% CI 0.7310-0.9789) and 0.8025 (95% CI 0.5771-1), respectively. …”

On the Viability of Heterolytic Peptide N–C_α Bond Cleavage in Electron Capture and Transfer Dissociation Mass Spectrometry by Matthew D. Wodrich (1344918)

“…Here, we further validate this mechanism using replica-exchange molecular dynamics to create unbiased representative sets of low-energy conformers for several model tryptic peptide systems (H-Ala_<i>x</i>-Lys-OH²⁺, <i>x</i> = 3–5). …”

Image3_Ablation Patterns of the Debris Covered Tongue of Halong Glacier Revealed by Short Term Unmanned Aerial Vehicle Surveys.jpeg by Wanqin Guo (450937)

“…However, ice cliffs show the strongest and the most significant ablation rates (averagely 1.36 and 1.22 m w.e. for supraglacial and lateral ice cliffs, respectively), followed by clean ice regions (1.01 m w.e.). …”

Table_1_Understanding the Cross-Talk of Redox Metabolism and Fe-S Cluster Biogenesis in Leishmania Through Systems Biology Approach.DOCX by Anurag Kumar (679730)

“…It was observed that the model was more sensitive to the perturbation introduced in TryR reaction, 5 to 6-fold. Furthermore, due to inhibition, the T[SH]₂ synthesis rate was observed to be gradually decreased by 8 to 14-fold. …”

Supplementary file 1_Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice.pdf by Yulia Dwi Setia (21590591)

“…Introduction<p>Eimeria pragensis, an intestinal protozoa infecting mice, induces colitis and reduces goblet cell numbers in the large intestine. In the present study, we investigated the pathogenesis and the mechanisms underlying goblet cell down-regulation in the early phase of infection.…”