RT-pPCR validation of microarray gene expression changes in human Met-5A pleural mesothelial cells following infection with D39 <i>Streptococcus pneumoniae</i>. by Claire J. Heath (826019)

“…RNA was extracted from pleural cells and analyzed on human microarrays. Mean fold expression changes were calculated for each gene from n = 5 experiments and a ≥ 2-fold increase/decrease was considered significant. …”

<i>Efnb1</i> and <i>Efnb2</i> mRNA are enriched in POMC neurons. by Manon Gervais (9708032)

DataSheet_1_Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer.doc by Shanqi Guo (8799437)

“…Otherwise, knockdown of SIRT1 significantly promotes AMPK/SREBP1 signaling and its associated target genes. Besides, we also found miR-138-5p was greatly inhibited the SIRT1 expression to regulating cell metabolism by targeting its 3′UTR region. …”

Hypothetical illustration of the two types of variability addressed in this paper. by Rebecca A. Lundwall (333179)

Image_5_Continued Decay of HIV Proviral DNA Upon Vaccination With HIV-1 Tat of Subjects on Long-Term ART: An 8-Year Follow-Up Study.JPEG by Cecilia Sgadari (120144)

“…CD4⁺ T cells increased above study-entry levels reaching a stable plateau at year 5 post-vaccination, with the highest increase (165 cells/μL) in the Tat 30 μg, 3 × regimen. …”

Image1_The 5HT4R agonist velusetrag efficacy on neuropathic chronic intestinal pseudo-obstruction in PrP-SCA7-92Q transgenic mice.JPEG by Yongqiang Liu (651861)

“…Currently, there are no drugs available to treat this disease. Herein, we report the characterization of the PrP-SCA7-92Q transgenic (Tg) line as a valuable CIPO mouse model and investigated the tolerability and efficacy of the 5-hydroxytryptamine type-4 receptor (5HT4R) agonist velusetrag as a promising pharmacological treatment for CIPO.…”

Image3_The 5HT4R agonist velusetrag efficacy on neuropathic chronic intestinal pseudo-obstruction in PrP-SCA7-92Q transgenic mice.JPEG by Yongqiang Liu (651861)

“…Currently, there are no drugs available to treat this disease. Herein, we report the characterization of the PrP-SCA7-92Q transgenic (Tg) line as a valuable CIPO mouse model and investigated the tolerability and efficacy of the 5-hydroxytryptamine type-4 receptor (5HT4R) agonist velusetrag as a promising pharmacological treatment for CIPO.…”

Image2_The 5HT4R agonist velusetrag efficacy on neuropathic chronic intestinal pseudo-obstruction in PrP-SCA7-92Q transgenic mice.JPEG by Yongqiang Liu (651861)

“…Currently, there are no drugs available to treat this disease. Herein, we report the characterization of the PrP-SCA7-92Q transgenic (Tg) line as a valuable CIPO mouse model and investigated the tolerability and efficacy of the 5-hydroxytryptamine type-4 receptor (5HT4R) agonist velusetrag as a promising pharmacological treatment for CIPO.…”

Quantification of serum cytokine levels. by Darrell Pilling (68014)

Deletion of <i>NUO2</i> triggers a ROS-dependent signaling pathway involving Hog1 activation and Brg1 repression in conditions when mannitol is the sole carbon source. by Xinhua Huang (1905940)

Presentation_1_MicroRNA Let-7f-5p Promotes Bone Marrow Mesenchymal Stem Cells Survival by Targeting Caspase-3 in Alzheimer Disease Model.ZIP by Linlin Han (3709822)

“…Cell pre-conditioning might help cope with this challenge. We tested whether let-7f-5p-modified MSCs could prolong the survival of MSCs after transplantation. …”

Image_5_Gut Microbiota-Derived Diaminopimelic Acid Promotes the NOD1/RIP2 Signaling Pathway and Plays a Key Role in the Progression of Severe Acute Pancreatitis.tif by Juying Jiao (6374129)

DataSheet1_Interactive Effects of Glucocorticoids and Cytochrome P450 Polymorphisms on the Plasma Trough Concentrations of Voriconazole.docx by Su-jie Jia (10869666)

“…Mutations of CYP2C19*2 and *3 increased C_min/dose of VRC, while CYP2C19*17 and CYP3A4 rs4646437 polymorphisms decreased C_min/dose of VRC. The mutation of CYP3A5 has no significant effect. …”

Frailty and quality of life among older people with and without a cancer diagnosis: Findings from TOPICS-MDS by Noralie Geessink (4688338)

“…A ten percent increase in frailty was also associated with a decrease in QOL at baseline (CSAL:-0.35 (95%-CI:-0.38;-0.32), EQ-5D:-0.12 (95%-CI:-0.12;-0.11)) and follow-up (CSAL:-0.27 (95%-CI:-0.30;-0.24), EQ-5D:-0.07 (95%-CI:-0.07;-0.06)). …”

Brain Intraventricular Injection of Amyloid-β in Zebrafish Embryo Impairs Cognition and Increases Tau Phosphorylation, Effects Reversed by Lithium - Figure 3 by Laura Roesler Nery (625675)

Image_3_Photoprotective Properties of Isothiocyanate and Nitrile Glucosinolate Derivatives From Meadowfoam (Limnanthes alba) Against UVB Irradiation in Human Skin Equivalent.TIF by Evan L. Carpenter (4750977)

Image_1_Photoprotective Properties of Isothiocyanate and Nitrile Glucosinolate Derivatives From Meadowfoam (Limnanthes alba) Against UVB Irradiation in Human Skin Equivalent.TIF by Evan L. Carpenter (4750977)

Image_2_Photoprotective Properties of Isothiocyanate and Nitrile Glucosinolate Derivatives From Meadowfoam (Limnanthes alba) Against UVB Irradiation in Human Skin Equivalent.TIF by Evan L. Carpenter (4750977)

DataSheet_2_Isoliquiritigenin Derivative Regulates miR-374a/BAX Axis to Suppress Triple-Negative Breast Cancer Tumorigenesis and Development.pdf by Fu Peng (1426402)

“…Recent studies suggest that isoliquiritigenin (ISL) can significantly suppress the growth, migration, and invasion of breast cancer cells. We previously synthesized ISL derivatives and found that 3′,4′,5′,4″-tetramethoxychalcone (TMC) inhibits TNBC cell proliferation to a greater degree than ISL. …”

Image_4_Photoprotective Properties of Isothiocyanate and Nitrile Glucosinolate Derivatives From Meadowfoam (Limnanthes alba) Against UVB Irradiation in Human Skin Equivalent.TIF by Evan L. Carpenter (4750977)