Epigenetic silencing of miR-203 in Kazakh patients with esophageal squamous cell carcinoma by MassARRAY spectrometry by Xiaobin Cui (553791)

“…Furthermore, miR-203 expression showed a nearly 4.5-fold decrease in ESCC than NETs (0.206 ± 0.336 vs. 0.908 ± 1.424, <i>P</i> < 0.001) and was significantly associated with lymph node metastasis <i>(P</i> = 0.012). …”

DataSheet1_Endothelial glycocalyx sensitivity to chemical and mechanical sub-endothelial substrate properties.PDF by Mohammad Hamrangsekachaee (12407143)

“…Subsequently, GelMA hydrogels were fabricated with stiffnesses of 2.5 and 5 kPa, representing healthy vessel tissues, and 10 kPa, corresponding to diseased vessel tissues. …”

Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools by Jun Ding (80820)

“…Both homoplasmies and heteroplasmies show 5-fold higher transition/transversion ratios than variants in nuclear DNA. …”

Video_1_Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion.MP4 by Peijun Jia (11334594)

“…Additionally, using TEM, we found that the TJ was markedly damaged on day 3 in the c-ICH model compared with that on day 5 in the b-ICH model. …”

DataSheet_1_FTO promotes liver inflammation by suppressing m6A mRNA methylation of IL-17RA.docx by Xiaojie Gan (13773058)

“…</p>Results<p>MeRIP-seq revealed the reduction of m6A mRNA methylation of IL-17RA in tumor adjacent tissues with chronic inflammation, suggesting the potential role of IL-17RA in the inflammation-carcinogenesis transformation of HCC. Besides, we demonstrated that FTO, rather than methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), and alkB homolog 5 (ALKBH5) functions as a main modulator for the decrease of m6A mRNA methylation of IL-17RA via knockdown and overexpression of FTO in vitro and in vivo.…”

Image_1_Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion.jpeg by Peijun Jia (11334594)

“…Additionally, using TEM, we found that the TJ was markedly damaged on day 3 in the c-ICH model compared with that on day 5 in the b-ICH model. …”

Impact of an Educational Program to Reduce Healthcare Resources in Community-Acquired Pneumonia: The EDUCAP Randomized Controlled Trial by Jordi Adamuz (812449)

“…<div><p>Background</p><p>Additional healthcare visits and rehospitalizations after discharge are frequent among patients with community-acquired pneumonia (CAP) and have a major impact on healthcare costs. We aimed to determine whether the implementation of an individualized educational program for hospitalized patients with CAP would decrease subsequent healthcare visits and readmissions within 30 days of hospital discharge.…”

Image_3_The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.tif by Guochao Liu (10450499)

“…Here, using the 7,12-dimethylbenz[α]anthracene (DMBA)-induced malignant transformed MCF10A cells, we found that valproate (VPA), a histone deacetylase inhibitor (HDACi), radiosensitized transformed cells while alleviated IR-induced damage in normal cells at a safe dose (0.5 mM). …”

Image_1_The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.tif by Guochao Liu (10450499)

“…Here, using the 7,12-dimethylbenz[α]anthracene (DMBA)-induced malignant transformed MCF10A cells, we found that valproate (VPA), a histone deacetylase inhibitor (HDACi), radiosensitized transformed cells while alleviated IR-induced damage in normal cells at a safe dose (0.5 mM). …”

Image_3_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

The Role of Growth Retardation in Lasting Effects of Neonatal Dexamethasone Treatment on Hippocampal Synaptic Function by Yu-Chen Wang (241511)

“…We confirmed that neonatal DEX treatment switched the direction of synaptic plasticity in hippocampal CA1 region, favoring low-frequency stimulation- and group I metabotropic glutamate receptor agonist (<em>S</em>)-3,5,-dihydroxyphenylglycine<b>-</b>induced long-term depression (LTD), and opposing the induction of long-term potentiation (LTP) by high-frequency stimulation in the adolescent period. …”

Contribution of a Non-β-Cell Source to β-Cell Mass during Pregnancy by Chiara Toselli (579816)

“…This suggests contribution of a non-β-cell source to the increase in total β-cell numbers during pregnancy. In addition, we observed a population of hormone-negative, Ngn3-positive cells in islets of both non-pregnant and pregnant mice, and this population dropped from 12% of all islets cells in the non-pregnant mice to 5% by day 8 of pregnancy. …”

Data Sheet 2_Altered gut microbial networks and metabolic pathways in multiple system atrophy: a comparative 16S rRNA study.csv by Po-Chun Liu (676035)

“…Additionally, we identified an increase in the ARGORNPROST-PWY pathway (L-arginine degradation, q = 0.003) and a decrease in the PWY-6478 pathway (GDP-D-glycero-α-D-manno-heptose biosynthesis, q = 0.015) in MSA patients compared with HCs.…”

Image_4_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

Image_4_The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.tif by Guochao Liu (10450499)

“…Here, using the 7,12-dimethylbenz[α]anthracene (DMBA)-induced malignant transformed MCF10A cells, we found that valproate (VPA), a histone deacetylase inhibitor (HDACi), radiosensitized transformed cells while alleviated IR-induced damage in normal cells at a safe dose (0.5 mM). …”

Supercooled Water Drops Impacting Superhydrophobic Textures by Tanmoy Maitra (1606972)

“…To this end, we describe an unobserved mechanism for superhydrophobicity breakdown: unlike for room temperature drops, where transition from bouncing to sticky (impaled) behavior occurs sharply at the condition of full texture penetration, with a bubble captured at the point of impact, under supercooled conditions, the full penetration velocity threshold is increased markedly (increasing by ∼25%, from 2.8 to 3.5 m/s) and no bubble is entrapped. …”

Data_Sheet_3_Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat.ZIP by Kalyan C. Vinnakota (43374)

“…We then measured plasma metabolite profiles in rats fasted for 5–7 or 10–13 h to test our model predictions. …”

DataSheet_2_Natal environmental conditions modulate senescence of antler length in roe deer.csv by Solène Cambreling (16493826)

“…We found evidence of similar patterns of antler length senescence in both populations, with an onset of senescence around 7 years of age and a decrease of length by about 1–1.5 cm per additional year of life from 7 years of age onwards. …”

A PU.1 Suppressive Target Gene, Metallothionein 1G, Inhibits Retinoic Acid-Induced NB4 Cell Differentiation by Naomi Hirako (605910)

“…Since G1 arrest is a hallmark of ATRA-induced NB4 cell differentiation, we observed a decrease in G1 accumulation, as well as decreases in p21^WAF1/CIP1 and cyclin D1 inductions, by ATRA in NB4MTOE cells. …”

Image_2_Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat.tif by Kalyan C. Vinnakota (43374)

“…We then measured plasma metabolite profiles in rats fasted for 5–7 or 10–13 h to test our model predictions. …”