Lung Macrophages Contribute to House Dust Mite Driven Airway Remodeling via HIF-1α by Adam J. Byrne (435998)

“…Blockade of HIF-1α <i>in vivo</i>, significantly decreased allergic inflammation and eosinophilia induced by allergen, due to a reduction in the levels of IL-5 and Eotaxin-2. …”

Hepatotoxicity or Hepatoprotection? Pattern Recognition for the Paradoxical Effect of the Chinese Herb <em>Rheum palmatum</em> L. in Treating Rat Liver Injury by Jia-bo Wang (124500)

“…To comparatively analyze the dose-response relationship between rhubarb and hepatic health, we administrated total rhubarb extract(RE) to normal and carbon tetrachloride(CCl₄)-treated rats for 12 weeks at 4 dosage levels(2.00, 5.40, 14.69 and 40.00 g·kg⁻¹, measured as the quantity of crude material), followed by biochemical and histopathological tests of the rats' livers. …”

datasheet1_Mutations of N1 Riboswitch Affect its Dynamics and Recognition by Neomycin Through Conformational Selection.pdf by Piotr Chyży (10159391)

“…Indeed, simulations of the unbound riboswitch show that G17 frequently stacks with base 7, while base 8 is stabilized towards the binding site in a way that it may interfere with the conformational selection mechanism and decrease riboswitch regulatory activity. In the riboswitch complexes, this single-point A to G mutation disrupts a strong hydrogen bond between nucleotides 5 and 17 and, instead, a new hydrogen bond between residue 17 and neomycin is created. …”

datasheet1_Mutations of N1 Riboswitch Affect its Dynamics and Recognition by Neomycin Through Conformational Selection.pdf by Piotr Chyży (10159391)

“…Indeed, simulations of the unbound riboswitch show that G17 frequently stacks with base 7, while base 8 is stabilized towards the binding site in a way that it may interfere with the conformational selection mechanism and decrease riboswitch regulatory activity. In the riboswitch complexes, this single-point A to G mutation disrupts a strong hydrogen bond between nucleotides 5 and 17 and, instead, a new hydrogen bond between residue 17 and neomycin is created. …”

Image_4_Maternal prebiotic supplementation impacts colitis development in offspring mice.TIF by Amélie Lê (14331069)

“…However, its role in modulating the development of other intestinal disorders, such as colitis, remains unknown. Therefore, we investigated the effects of prebiotic supplementation in pregnant mice on the occurrence of colitis in their offspring.…”

Suppressing TLR4 alleviates cerebral injury in heatstroke rats through the modulation of microglial polarization by Xiaomin Wu (20328165)

“…</p><p dir="ltr"><b>Methods:</b><b> </b>We established a HS rat model by placing rats in a controlled artificial climate chamber at a temperature of 40±0.5°C until their rectal core temperature (Tc) reached 42°C, which is the established threshold for diagnosing HS. …”

DataSheet_3_Green tea extract suppresses airway inflammation via oxidative stress-driven MAPKs/MMP-9 signaling in asthmatic mice and human airway epithelial cells.xlsx by Jeong-Won Kim (18464976)

“…GTE treatment decreased OVA-induced mucus secretion and airway inflammation. …”

Image_6_The Indispensable Role of Histone Methyltransferase PoDot1 in Extracellular Glycoside Hydrolase Biosynthesis of Penicillium oxalicum.TIF by Yanan Li (94033)

“…<p>Histone methylation is associated with transcription regulation, but its role for glycoside hydrolase (GH) biosynthesis is still poorly understood. We identified the histone H3 lysine 79 (H3K79)-specific methyltransferase PoDot1 in Penicillium oxalicum. …”

Table_4_Muscle-origin creatinine-cystatin C ratio is an osteoporosis marker in individuals with normal renal function: evidence from observational and Mendelian randomization analy... by Pei He (836326)

“…Background<p>Creatinine-cystatin C ratio (CCR) has been demonstrated as an objective marker of sarcopenia in clinical conditions but has not been evaluated as an osteoporosis marker in individuals with normal renal function.</p>Methods<p>We selected 271,831 participants with normal renal function from UK Biobank cohort. …”

Primer sequences. by Koichi Yoshimoto (9298643)

“…Immunohistochemistry showed that the KUS121 treatment reduced the number of apoptotic cells in the distal third of the flap (p < 0.01); moreover, in the KUS121-treated rats, the number of cells expressing CHOP, an endoplasmic reticulum (ER) stress marker, in the middle third of the flap was significantly lower than in the controls (p < 0.01). We examined the mRNA expression of <i>Ddit3</i> (CHOP) and <i>Casp3</i> (caspase-3) on day one after the surgery; mRNA expression of both genes appeared to decrease in the KUS121 group, as compared with the control group, although differences between groups were not significant. …”

DataSheet1_Rivaroxaban in heart failure patients with left ventricular thrombus: A retrospective study.DOCX by Qian Zhang (49333)

“…High rates of major cardiovascular adverse events (MACEs) were observed in both the rivaroxaban and VKAs groups (49.5% vs. 57.7%). However, rivaroxaban versus VKAs observed a decrease in MACEs (adjusted HR:0.636; 95%CI:0.418–0.970; p = 0.035) and systemic embolism (4.6% vs. 12.8%; adjusted HR:0.318; 95%CI:0.108–0.933; p = 0.037; Gray’s test p = 0.041) but was not found to have a benefit with regard to LV thrombus resolution (59.6% vs. 70.6%; adjusted HR: 1.303; 95% CI:0.898–1.890; p = 0.163; Gray’s test p = 0.073). …”

Conditional cash transfer programme: Impact on homicide rates and hospitalisations from violence in Brazil by Daiane Borges Machado (732859)

“…</p><p>Findings</p><p>Homicide rates and hospitalization from violence decreased as BFP coverage in the target population increased. …”

Table3_Efficacy and safety of fenofibrate add-on therapy in patients with primary biliary cholangitis refractory to ursodeoxycholic acid: A retrospective study and updated meta-ana... by Xuan Guoyun (13521745)

“…Biochemical and clinical indicator changes in UDCA-refractory PBC patients receiving combination therapy were analyzed by Revman 5.42. Then, we explored the influence of fenofibrate dose and the effectiveness and safety of long-term application by retrospective cohort study.…”

Table_1_Multilevel Evaluation of Rapid Weight Loss in Wrestling and Taekwondo.docx by Cecilia Castor-Praga (10575626)

“…This type of practice could increase health risks and decrease their performance. Therefore, here we state the importance of a comprehensive evaluation of RWL strategies that allows the development of psycho-educational and social-based interventions and programs for the promotion of proper weight maintenance, and prevention against RWL strategies, involving the individuals who influence the adoption of these practices and supporting it with the help of communication technologies.…”

DataSheet1_A new type of simulated partial gravity apparatus for rats based on a pully-spring system.pdf by Shenke Zhang (13543141)

“…In this experiment, 25 seven-week-old male Wistar Hannover rats were randomly divided into five groups (n = 5 per group): hindlimb full weight-bearing control (1G), sham (1G), and the simulated gravity groups including Mars (3/8G), Moon (1/6G), and interplanetary space (microgravity: µG). …”

Image_3_Maternal prebiotic supplementation impacts colitis development in offspring mice.TIF by Amélie Lê (14331069)

“…However, its role in modulating the development of other intestinal disorders, such as colitis, remains unknown. Therefore, we investigated the effects of prebiotic supplementation in pregnant mice on the occurrence of colitis in their offspring.…”

Upper-crust thermal evolution of the Patagonian Precordillera basement (Argentina): insights from fission track, (U-Th)/He thermochronology and geodynamic significance by Paulo Marcos (7459064)

“…Subsequently, a relatively fast temperature decrease (2.75–5°C/My) for the late Early Cretaceous to Paleocene is likely related to a compressive stage associated with the growth of the early Andean Orogen. …”

A comparison of the effectiveness of three LED phototherapy machines, single- and double-sided, for treating neonatal jaundice in a low resource setting by Gaston Arnolda (5848664)

“…In addition, the double-sided machine was associated with 21% reduction in the duration of treatment (14 hours, 95% CI 5–22) and 16% reduction of length of stay (14 hours, 95% CI 3–25).…”

State of multimeric system for varying strengths of <i>ϵ</i>_ns. by Rakesh Krishnan (12519627)

“…B) For weak <i>ϵ</i>_ns = 0.1 k_BT we observe neglibile non-specific contacts in the system (N_ns ≈ 0). …”

Image_4_The Indispensable Role of Histone Methyltransferase PoDot1 in Extracellular Glycoside Hydrolase Biosynthesis of Penicillium oxalicum.TIF by Yanan Li (94033)

“…<p>Histone methylation is associated with transcription regulation, but its role for glycoside hydrolase (GH) biosynthesis is still poorly understood. We identified the histone H3 lysine 79 (H3K79)-specific methyltransferase PoDot1 in Penicillium oxalicum. …”