Effect of Molecular Structure on the B3LYP-Computed HOMO–LUMO Gap: A Structure −Property Relationship Using Atomic Signatures by Ahmed Mohamed (628889)

“…The atomic fragments containing π-bonds in various aromatic compounds were found to be the most significant atomic Signatures, explaining nearly 50% of the variance in the data, with regression coefficients that decreased <i>E</i>_gap. …”

The Strong <i>In Vivo</i> Anti-Tumor Effect of the UIC2 Monoclonal Antibody Is the Combined Result of Pgp Inhibition and Antibody Dependent Cell-Mediated Cytotoxicity by Gábor Szalóki (631712)

“…However, this inhibition is partial, since UIC2 binds only to 10–40% of cell surface Pgps, while the rest becomes accessible to this antibody only in the presence of certain substrates or modulators (e.g. cyclosporine A (CsA)). The combined addition of UIC2 and 10 times lower concentrations of CsA than what is necessary for Pgp inhibition when the modulator is applied alone, decreased the EC₅₀ of doxorubicin (DOX) in KB-V1 (Pgp⁺) cells <i>in vitro</i> almost to the level of KB-3-1 (Pgp^-) cells. …”

DataSheet1_Monoclonal Antibodies Targeting IL-5 or IL-5Rα in Eosinophilic Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.DOCX by Chuchu Zhang (2562154)

“…This meta-analysis aimed to determine the efficacy and safety of anti-IL-5 therapy in eosinophilic COPD.</p><p>Methods: We searched the PubMed, Web of Science, Embase, and Cochrane Library databases from inception to August 2020 (updated in June 2021) to identify studies comparing anti-IL-5 therapy (including mepolizumab, benralizumab, and reslizumab) with placebo in eosinophilic COPD patients.…”

DataSheet1_Preparation of rambutan-like Co0.5Ni0.5Fe2O4 as anode for high–performance lithium–ion batteries.PDF by Qian Wang (32718)

“…<p>NiFe₂O₄ is a kind of promising lithium ion battery (LIB) electrode material, but its commercial applications have been limited due to the electronic insulation property and large volume expansion during the conversion reaction process, which results in rapid capacity decrease and poor cycling stability. We synthesized rambutan-like Co_0.5Ni_0.5Fe₂O₄ using the self-templating solvothermal method. …”

Fig 3 - by Jianfeng Yang (49036)

Subgroup analysis. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

Study outcomes. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

Number of structural scans per age group. by Stefania Conte (9349517)

“…Following the first steep increase in WM volume during infancy and childhood, the rate of development slows down in adulthood and decreases with aging. Similarly, microstructural properties of WM, particularly fractional anisotropy (FA) and mean diffusivity (MD), follow independent rates of change across the lifespan. …”

LP I_h metamodulation is rapid and reversible. by Wulf-Dieter C. Krenz (693267)

“…The percent change in LP I_h G_max relative to t = 0 is plotted (mean±SEM, increases are positive, decreases are negative). …”

Knock-out of <i>atp6v1e1b</i> in zebrafish shows an early phenotypic read-out. by Lore Pottie (10994479)

“…Data are expressed as mean ± SD from 5 biological replicates. (C) Band intensities of fluorescence signals of atp6v1e1 and α-tubulin were quantified and normalized to the corresponding WT controls. …”

Diagram illustrating thalamic network model and its cortical inputs. by Austin E. Soplata (4676017)

Assessment of tissue revascularization and immune cell infiltrate in saline or MP-treated TK-I/R injured muscles 14 days post-reperfusion. by Viktoriya Rybalko (840821)

Supplemental figures for manuscript entitled: Tumor Suppressors RBL1 and PTEN are Epigenetically Silenced in IPF Mesenchymal Progenitor Cells by a CD44/Brg1/PRMT5 Regulatory Comple... by Craig Henke (9406202)

“…We demonstrate that expression of the tumor suppressor genes <i>rbl1</i> and <i>pten</i> is decreased in IPF MPCs. …”

Structural Studies of the <i>Methylosinus trichosporium</i> OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel by Jason C. Jones (9191264)

“…The kinetics of reaction of O₂ with the diferrous sMMOH:MMOB complex in solution show that use of the MMOB V41R variant decreases the rate constant for O₂ binding >25000-fold without altering the component affinity. …”

Structural Studies of the <i>Methylosinus trichosporium</i> OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel by Jason C. Jones (9191264)

“…The kinetics of reaction of O₂ with the diferrous sMMOH:MMOB complex in solution show that use of the MMOB V41R variant decreases the rate constant for O₂ binding >25000-fold without altering the component affinity. …”

Augmented Dicky-Fuller tests for unit roots. by Taimoor Ahmad (8940146)

“…A one percent increase in vaccinations decreased deaths by 0.38% (95% CI: -0.67, -0.08) in wave 5 and the association is statistically significant.…”

Canonical T7SS substrate EsxA is conserved across GBS T7SS subtypes I—III. by Brady L. Spencer (7294382)

Maximum network frequencies under TC cell propofol multiplier extremes. by Austin E. Soplata (4676017)

Adverse events ^a. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”

Rhinorrhea-free days up to day 10. by Bruno Martins Tomazini (6509528)

“…</p><p>Results</p><p>From September 25, 2021, to February 3, 2022, 153 patients were randomized. The mean decay rate in SARS-CoV-2 viral load log₁₀ within 10 days was -3.75 (95% CI, -4.11; -3.19) in the placebo group, -3.83 (95% CI, -4.40; -2.27) in the halofuginone 0.5mg group and -4.13 (95% CI, -4.69; -3.57) in the halofuginone 1mg group, with no statistically significant difference in between placebo vs. halofuginone 0.5mg (mean difference -0.08; 95% CI -0.82 to 0.66, p = 0.96) and between placebo vs. halofuginone 1mg (mean difference -0.38; 95% CI, -1.11; 0.36, p = 0.41). …”