Table_5_Pregnancy-Induced Changes in microRNA Expression in Multiple Sclerosis.xlsx by Helle Bach Søndergaard (10044584)

Activated CD4+ CD45RO+ memory T-cells decrease secretion of soluble caspase-1 and P2X7R mRNA expression in monocytes leading to a reduced response upon ATP binding. by Vanessa Beynon (153924)

“…<p>a) sCaspase-1 levels in the supernatant of monocytes was measured by ELISA (n = 8). A significant decrease of soluble Caspase-1 in the supernatant of cells co-cultured with activated memory T-cells was observed both in the presence and absence of IFNβ; b) intracellular levels of pro-IL-1β measured with an ELISA specific for the immature precursor of IL-1β showed a significant increase in pro-IL-1β levels in the presence of human activated CD4+CD45RO+ memory T-cells (n = 3), cell lysates from adherent monocytes were obtained after removal of non-adherent T-cells after addition of LPS and prior to incubation with ATP c) the ratio of intracellular pro-IL-1β to released soluble Caspase-1 is significantly increased in the presence of human activated CD4+CD45RO+ memory T-cells (n = 3). d) <i>P2X7R</i> mRNA expression in monocytes cultured overnight with activated CD4+CD45RO+ memory T-cells is decreased with and without addition of exogenous IFNβ (n = 3), mRNA was isolated from adherent monocytes after removal of non-adherent T-cells after addition of LPS and prior to incubation with ATP (Data are shown as means ± SD of duplicate cultures; *p<0.05; **p<0.01 employing repeated measures ANOVA with post-hoc Bonferroni adjustment for multiple comparisons to avoid random correlations); e) Ca²⁺-influx measurement in monocytes cultured with activated human CD4+CD45RO+ memory T-cells in the presence of IFNβ demonstrates the absence of slow sustained Ca²⁺-influx mediated by ATP binding to the purinergic P2X7-receptor (representative of 3 independent experiments); f) Annexin V staining of monocytes coincubated with T-cells and stimulated with LPS was measured by flow cytometry (representative flow cytometry histogram of n = 5).…”

Table_5_Influence of Belowground Herbivory on the Dynamics of Root and Rhizosphere Microbial Communities.xlsx by Morgane Ourry (5450048)

Image_5_Methylated tirilazad may mitigate oligofructose-induced laminitis in horses.TIFF by Maimaiti Tuniyazi (9948961)

Identification of Small Molecules that Disrupt Signaling between ABL and Its Positive Regulator RIN1 by Pamela Y. Ting (713174)

“…The CML cell line K562 was then used to identify five compounds that decrease MAPK1/3 phosphorylation, which we determined to be an indicator of RIN1-dependent ABL signaling. …”

Image_5_ECT9 condensates with ECT1 and regulates plant immunity.tif by Hui Wang (30400)

Effect of elastase injection on <i>Fbln5</i> Cre+cKO mice. by Kathleen Chin (275937)

“…F5^-/-, negative control; Ctl, nonpregnant wild type; PP, 48 h postpartum wild type control indicating decrease in Fbln5. …”

Proportion of participants reporting a COVID-19 test among those reporting test-qualifying symptoms. by Mark S. Graham (4484317)

Concentration of suspended solids (mg /l) in six concentrations of water turbidity. by Javier Manjarrez (531011)

The evolution of the Extra-Metabolic Scholander-Irving model. by Halley B. Hughes (15198112)

Time-course of BCR-ABL and SFK dephosphorylation after treatment with inhibitors. by Adam Obr (541887)

Decreased levels of CIITApIV H3K18ac, H3K27ac and CBP correlate with significantly elevated levels of H3K27me3 in metastatic breast cancer cells. by Agnieszka D. Truax (169208)

Etesevimab in combination with JS026 neutralizing SARS-CoV-2 and its variants by Fengze Wang (10452968)

“…As an antiviral agent, numerous mAbs recognize the epitopes that overlap with ACE2-binding sites in the SARS-CoV-2-RBD. Some studies have shown that residual changes on the spike protein can significantly decrease the efficiency of neutralizing antibodies. …”

Insights into SARS-CoV-2’s Mutations for Evading Human Antibodies: Sacrifice and Survival by Binquan Luan (1288623)

“…However, the K417N mutation appears to be unfavorable as it removes one interfacial salt bridge. Here, we show that despite the decrease in binding affinity (1.48 kcal/mol) between RBD and ACE2, the K417N mutation abolishes a buried interfacial salt bridge between the RBD and neutralizing antibody CB6. …”

Insights into SARS-CoV-2’s Mutations for Evading Human Antibodies: Sacrifice and Survival by Binquan Luan (1288623)

“…However, the K417N mutation appears to be unfavorable as it removes one interfacial salt bridge. Here, we show that despite the decrease in binding affinity (1.48 kcal/mol) between RBD and ACE2, the K417N mutation abolishes a buried interfacial salt bridge between the RBD and neutralizing antibody CB6. …”

SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors by Amy Tasca (5725028)

“…We analyzed male mice at 3 months of age to determine the skeletal phenotype of the <i>Smad1</i>^<i>fl/fl</i>; <i>Smad5</i>^<i>fl/fl</i><i>;c-Fms-Cre</i> (SMAD1/5 cKO) mice. …”

Image_5_Gut Microbiome and Metabolome Changes in Mice With Acute Vestibular Deficit.jpeg by Feitian Li (12340255)

Cu on Co Improves C₅₊ Selectivity in the Fischer–Tropsch Synthesis by Charles-David Guérette (21244235)

“…Co15–Cu0.15 was determined to yield the most C₅₊ hydrocarbons and decrease the yield of C₃₊, complementing our experimental results.…”

pH Landscapes in a Novel Five-Species Model of Early Dental Biofilm by Sebastian Schlafer (144783)

miRNA expression in pooled samples from univentricular heart failure patients. by Sweta Ramachandran (169036)

“…<p>Pooled sera from patients with Ross scores <3, 3–5, and >5 were evaluated for expression of miRNAs previously implicated as biomarkers of HF in adult patients. miR129-5p showed a decrease in expression with increasing Ross score. …”