Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. The anti-mTNF conjugate <b>ADC5</b> fully inhibited inflammation in mouse contact hypersensitivity with minimal effects on corticosterone, a biomarker for systemic GRM effects, at doses up to and including 100 mg/kg. …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. The anti-mTNF conjugate <b>ADC5</b> fully inhibited inflammation in mouse contact hypersensitivity with minimal effects on corticosterone, a biomarker for systemic GRM effects, at doses up to and including 100 mg/kg. …”

Parrotfish Teeth: Stiff Biominerals Whose Microstructure Makes Them Tough and Abrasion-Resistant To Bite Stony Corals by Matthew A. Marcus (115744)

“…These fibers gradually decrease in average diameter from 5 μm at the back to 2 μm at the tip of the tooth. …”

Parrotfish Teeth: Stiff Biominerals Whose Microstructure Makes Them Tough and Abrasion-Resistant To Bite Stony Corals by Matthew A. Marcus (115744)

“…These fibers gradually decrease in average diameter from 5 μm at the back to 2 μm at the tip of the tooth. …”

Parrotfish Teeth: Stiff Biominerals Whose Microstructure Makes Them Tough and Abrasion-Resistant To Bite Stony Corals by Matthew A. Marcus (115744)

“…These fibers gradually decrease in average diameter from 5 μm at the back to 2 μm at the tip of the tooth. …”

Parrotfish Teeth: Stiff Biominerals Whose Microstructure Makes Them Tough and Abrasion-Resistant To Bite Stony Corals by Matthew A. Marcus (115744)

“…These fibers gradually decrease in average diameter from 5 μm at the back to 2 μm at the tip of the tooth. …”

Real-time RT-PCR analysis. by Jin Zhu (164147)

Unique Biofilm Signature, Drug Susceptibility and Decreased Virulence in <em>Drosophila</em> through the <em>Pseudomonas aeruginosa</em> Two-Component System PprAB by Sophie de Bentzmann (116508)

Donor baseline demographic data. by Parichart Permpikul (15626559)

“…<div><p>SARS-CoV-2 virus infection has imposed a significant healthcare burden globally. …”

Decreased proliferation in <i>Csf1r^−/−</i> and <i>Csf1^op/op</i> mouse colonic epithelium. by Duy Huynh (381445)

“…(<b>B</b>) Enumeration of the total number of positively stained nuclei reveals that average number of proliferating cells/crypt is significantly reduced in proximal (left panel) and distal (right panel) colons of <i>Csf1^op/op</i> and <i>Csf1r^−/−,</i> compared to WT, mice. Bar = 50 µm (n = 3). (<b>C</b>) Staining with the G₂/M phase marker, phosphorylated histone H3 (PH-3, black arrows) also shows decreased numbers of cells in cycle per crypt in both mutants. …”

Exploring reopening strategies for a high range in disease transmission <i>v</i>_<i>r</i> with high testing capacity. by Mackenzie Dalton (14093874)

IgG_NC and IgG_SP level. by Parichart Permpikul (15626559)

“…<div><p>SARS-CoV-2 virus infection has imposed a significant healthcare burden globally. …”

Factors associated with low IgG_SP <1042.6 AU/ml. by Parichart Permpikul (15626559)

“…<div><p>SARS-CoV-2 virus infection has imposed a significant healthcare burden globally. …”

DataSheet1_v1_Selection Cuttings as a Tool to Control Water Table Level in Boreal Drained Peatland Forests.PDF by Kersti Leppä (9501851)

“…Using a process-based ecohydrological model, tested against data from the field trials, we show that the role of tree stand in controlling the WTL clearly decreases along the latitudinal climate gradient in Finland. …”

Room-Temperature Photoferroelectrics Semiconductor Driven by the Interlayer Confinement Effect by Yueyue He (10821234)

“…However, research on regulating ferroelectrics through the interlayer confinement effect in two-dimensional (2D) OIHPs is still rare. Herein, we regulated the strength of interlayer confinement by changing the length of the alkyl chain on organic cations, and precisely constructed a lead bromide ferroelectric (IPA)₂PbBr₄ (IPA⁺ is isopropylammonium) with a high Curie temperature (<i>T</i>_c) of 340.5 K and a spontaneous polarization (<i>P</i>_s) of 3.16 μC/cm² through a strong interlayer confinement effect. …”

Room-Temperature Photoferroelectrics Semiconductor Driven by the Interlayer Confinement Effect by Yueyue He (10821234)

“…However, research on regulating ferroelectrics through the interlayer confinement effect in two-dimensional (2D) OIHPs is still rare. Herein, we regulated the strength of interlayer confinement by changing the length of the alkyl chain on organic cations, and precisely constructed a lead bromide ferroelectric (IPA)₂PbBr₄ (IPA⁺ is isopropylammonium) with a high Curie temperature (<i>T</i>_c) of 340.5 K and a spontaneous polarization (<i>P</i>_s) of 3.16 μC/cm² through a strong interlayer confinement effect. …”

Growth Kinetics of Elementary Spiral Steps on Ice Prism Faces Grown in Vapor and Their Temperature Dependence by Genki Miyamoto (13914416)

“…Then, we revealed that the value of β on prism faces monotonically decreases with decreasing temperature (<i>T</i>) from −2.6 to −25.0 °C. …”

Corn gluten meal induces enteritis and decreases intestinal immunity and antioxidant capacity in turbot (<i>Scophthalmus maximus</i>) at high supplementation levels - Fig 2 by Nan Bai (1576645)

“…</b> (a–d) Representative images of decreased height and increased fusion of the mucosal folds with increasing corn gluten meal level (bar = 500 <b>μ</b>m). …”

BrdU-positive mossy cell precursors are decreased in the hilus of developing Rac1^N/Rac3^KO mice. by Roberta Pennucci (83950)

Image_1_Plasticity in the Sensitivity to Light in Aging: Decreased Non-visual Impact of Light on Cognitive Brain Activity in Older Individuals but No Impact of Lens Replacement.PDF by Véronique Daneault (5933561)

“…Whether the stimulating effects light on cognitive brain functions varies in aging and how ocular changes may be involved is not established. We compared the impact of blue and orange lights on non-visual cognitive brain activity in younger (23.6 ± 2.5 years), and older individuals with their natural lenses (NL; 66.7 ± 5.1 years) or with intraocular lens (IOL) replacement following cataract surgery (69.6 ± 4.9 years). …”