SBDS expression is downregulated during PLB-985 neutrophil differentiation. by Claudia Orelio (217728)

“…(B) Representative quantitative RT-PCR analysis shows that SBDS mRNA expression decreases 1.8 fold with PLB-985 neutrophil differentiation (n = 5), showing the mean±SEM. …”

Inhibition of the Wnt pathway by SFRP2 reduced mCSCs’ resistance to H₂O₂-induced apoptosis. by Jingjin Liu (393236)

“…<p>(A) Total mRNA was isolated from mCSCs treated with a range of concentrations of the SFRP2 protein (0, 3, 10, 15, 20, 50, 100 and 150 nM) for 24 h in serum-free medium. …”

Inhibition of actin perturbs the kinetics of dynamin recruitment, but has minimal impact on GAK recruitment. by Marcus J. Taylor (173337)

“…<p>(A) Acute inhibition of actin decreased the amplitude of peak dyn1(WT)-mCherry recruitment. …”

Changing expression of candidate modifier genes alters larval density in the <i>AKHRi</i> model. by Audrey Nicol (19500765)

“…A positive change (>0) represents decreased FC50 and is suggestive of increased fat storage in the modifier strain as compared to the genetically-matched control. …”

An explanation of the pRF dynamics in terms of feedback signals from extrastriate cortex. by Koen V. Haak (321925)

“…Interestingly, this model also predicts that increasing the size of the mask (shifting the fringe to the right) results in a decrease of the pRF expansion. This is indeed what appears to happen when the mask size increases from 5.0° to 7.5° (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037686#pone-0037686-g004" target="_blank">Figure 4B</a> and corresponding text).…”

The effects of MS patients' sera on the tight junction proteins and adhesion molecules in TY09 cells. by Fumitaka Shimizu (545145)

“…(E)(F) The amount of claudin-5 protein in TY09 cells was significantly decreased after the exposure to sera from SPMS or RRMS-R patients, and the amount of occludin protein in TY09 cells was significantly reduced after exposure to sera from SPMS patients, whereas the amounts of the claudin-5 and occludin proteins were not significantly affected by exposure to sera from RRMS-S patients or healthy controls. …”

Datasheet1_Expected small left heart size in the presence of congenital diaphragmatic hernia: Fetal values and Z-scores for infants confirmed to have no heart disease postnatally.p... by Anita J. Moon-Grady (14223251)

“…CDH-specific models derived from log-transformed values yielded left-shifted distributions, reflecting the small structures (mean z-score lower by: MV 0.99 ± 0.30, AoV 2.04 ± 0.38, LV length 1.30 ± 0.36, and LV width 4.69 ± 0.28; p < 0.0001 for all comparisons). …”

How well do lower femoral neck shaft angled stems match patients with coxa vara hip deformities? by Omar Alnachoukati (4717029)

“…<br><b>Results:</b> In the EOS group, mean femoral offset decreased by 3.5 mm, from 41.08 mm preoperatively to 37.6 mm postoperatively. …”

Generation of Atoh1-LKB1^-/- conditional knockout mice. by Yuqin Men (783410)

“…(D) The body weight of male and female mice from WT and mutant mice was measured. The mutant mice exhibited significant decreases in weight compared to those of the control group after P21. …”

Supplementary Figure 2 by Julie Goodwin (16642647)

“…<p>Representative Masson Trichrome staining of kidney, heart, liver and adipose tissue in vehicle-treated and Wnti-treated <em>db/db</em>;<em>GRECKO</em> mice demonstrates significantly decreased area of fibrosis in all organs studied. n=5/group. …”

Reduction in Wnt receptor or ligand disrupts nuclear β-catenin asymmetry, cousin enrichment, and division orientations. by Amanda L. Zacharias (698358)

“…Divisions with low polarity are also significantly increased for <i>mom-5(or57)</i> and <i>cwn-1/2</i> + <i>mom-2</i>i.…”

Double fluorescence study by flow cytometry of CD45RO lymphocytes subpopulations and apoptosis by CD8⁺CD25⁺ regulatory T cells during IVMP. by Yi-Giien Tsai (514981)

“…(c). siRNA of FoxP3 decreased granzyme B protein expression in CD8⁺CD25⁺ Treg cells if pretreated with nucleosomal histone peptide epitope (H3:115–135) and dexamethasme (50 nM). …”

Adult lifespan in nickel-spiked sediment – survivorship curves. by David Rudel (467731)

“…<p>Recovery of <i>Cel-fog-2</i> females from WB spiked nickel sediments, WB-0 (blue circles), WB-2 (green triangle), WB-3 (black asterisks), and WB-5 (red squares). Survivability decreases as nickel increases. Yellow-orange dotted line represents a 50% recovery. …”

Image5_Effect of Rumex dentatus on Gastrointestinal Protection and Toxicology in Rodents via Investigating H+/K+-ATPase, Calcium Channels, and PDE Mediated Signaling.tiff by Neelam Gul Qazi (13178827)

“…Extracts and emodin also show an inhibitory effect against H⁺/K⁺-ATPase. Rumex dentatus showed a gastroprotective and antioxidant effect. Histopathological evaluation showed improvement in cellular architecture and decrease in the expression of inflammatory markers such as cyclooxygenase (COX2), tumor necrosis factor (TNF-α), and phosphorylated nuclear factor kappa B (p-NFƙB), validated through immunohistochemistry, ELISA, and western blot techniques. …”

Increased BMP/TGFB signaling pathway activity in <i>Rx > cre Myrf</i>^<i>fl/fl</i> mutants. by Michelle L. Brinkmeier (18709048)

“…(C-<i>Myrf</i>^<i>fl/fl</i>; M-<i>Rx > cre Myrf</i>^<i>fl/fl</i>) (B) VlnPlot representation of transcript levels of <i>Wfikkn2</i>, <i>Tgfb2,</i> and <i>Id3</i> in theRPE cluster highlighting a decrease in the pathway inhibitor, <i>Wfikkn2</i> and increases in <i>Tgfb2</i> and <i>Id3</i>. …”

Image1_Effect of Rumex dentatus on Gastrointestinal Protection and Toxicology in Rodents via Investigating H+/K+-ATPase, Calcium Channels, and PDE Mediated Signaling.tiff by Neelam Gul Qazi (13178827)

“…Extracts and emodin also show an inhibitory effect against H⁺/K⁺-ATPase. Rumex dentatus showed a gastroprotective and antioxidant effect. Histopathological evaluation showed improvement in cellular architecture and decrease in the expression of inflammatory markers such as cyclooxygenase (COX2), tumor necrosis factor (TNF-α), and phosphorylated nuclear factor kappa B (p-NFƙB), validated through immunohistochemistry, ELISA, and western blot techniques. …”

<i>Spidey</i> expression during development is essential for adult survival. by Yin Ning Chiang (1718815)

“…Survival % is calculated as the number of successfully eclosed adults relative to the total number of male and female embryos; E: embryo; L1: 1^st instar larvae; L2: 2^nd instar larvae; L3: 3^rd instar larvae; P: pupae. N = 50 embryos for each stage. See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006126#pgen.1006126.s012" target="_blank">S6 Table</a> for full genotypes. …”

Effect of Intramuscular Injection of pH, lactate, ATP, and α,β–meATP on Muscle Withdrawal Threshold. by Nicholas S. Gregory (796912)

“…<p>Muscle withdrawal threshold was measured before and 30 minutes after injection of physiologic and supraphysiologic concentrations of pH, lactate, ATP, and α,β–meATP. (A) pH dose response curve. Rats were injected with normal saline adjusted to neutral pH (n = 6), pH 4.0 (n = 12), pH 4.5 (n = 6), pH 5.0 (n = 6), and pH 6.0 (n = 6). …”

Table1_Effect of Rumex dentatus on Gastrointestinal Protection and Toxicology in Rodents via Investigating H+/K+-ATPase, Calcium Channels, and PDE Mediated Signaling.docx by Neelam Gul Qazi (13178827)

“…Extracts and emodin also show an inhibitory effect against H⁺/K⁺-ATPase. Rumex dentatus showed a gastroprotective and antioxidant effect. Histopathological evaluation showed improvement in cellular architecture and decrease in the expression of inflammatory markers such as cyclooxygenase (COX2), tumor necrosis factor (TNF-α), and phosphorylated nuclear factor kappa B (p-NFƙB), validated through immunohistochemistry, ELISA, and western blot techniques. …”

Table_1_Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice.XLSX by Chunmei Jin (5705060)

“…We also re-analyzed previously reported RNA-sequencing results of the striatum of adult Shank3 TG mice and of the prefrontal cortex of juvenile Shank3^+/^Δ^C mice with a 50–70% reduction of Shank3 proteins. We found that several myelin-related genes were significantly downregulated specifically in the mPFC, but not in the striatum or hippocampus, of adult Shank3 TG mice by comparing the differentially expressed genes (DEGs) of the analyses side by side. …”