Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents by Yujuan Li (554062)

“…Among these, Compound <b>13</b>, featuring an oxopropyl group at the <i>ortho</i>-position of quinone group, exhibited the most potent inhibitory effects on HCT116, PC9, and A549 cells, with IC₅₀ values decreasing from 5.27 to 1.18 μM (4.5-fold increase), 6.98 to 0.57 μM (12-fold increase), and 5.88 to 2.25 μM (2.6-fold increase), respectively, compared to compound <b>5</b>. …”

Frosting Behavior of Superhydrophobic Nanoarrays under Ultralow Temperature by Wenwen Zhang (331647)

“…Although the frosting event inevitably occurs on all surfaces when the temperature is decreased from −50 to −150 °C, the frost accumulation on the superhydrophobic surfaces is always less than that on the untreated surfaces. …”

Selected epigenetic signals drive hNPCs to become oligodendrocytes in vitro. by Margherita Neri (250787)

“…<p>(<b>A, B</b>) Exposure of hNSCs to FPN or PDGF-AA+T3 increased the numbers of NG2⁺, O4⁺ GalCer⁺ oligodendroglil cells (<b>A</b>) and TUJ1⁺ neuronal cells (<b>B</b>), while decreasing the numbers of astroglial cells (<b>B</b>) compared to the default differentiation protocol (FCS). …”

Table 1_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le... by Ting Yang (189879)

“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”

Supplementary Material for: The Association of Visually Guided Saccades and DAT-SPECT Findings in Parkinson’s Disease by Kobayashi M. (6077225)

“…VGSs were evoked by a white dot on a monitor, which was presented at the center and pseudo-randomly jumped off horizontally (10° or 20° eccentricity) or vertically (10° or 15°). …”

Data_Sheet_1_Forest Fire Severity Affects Host Plant Quality and Insect Herbivore Damage.docx by Shannon M. Murphy (140163)

“…Notably, high severity fires decreased herbivore damage by about 50%. Furthermore, we found that the effect of fire on insect herbivore damage is mostly direct, but that indirect effects mediated through changes in plant quality are also significant. …”

DZNep partially competes with the uptake of purine nucleosides by hENT1 and hCNT3. by Sau Wai Hung (102677)

“…<p>A. DZNep hindered the uptake of radiolabeled purine nucleosides in PANC-1 and MIA PaCa-2. …”

Rapamycin regulates the Akt-mTOR network in Pten-deficient keratinocytes and delays wound healing. by Cristiane H. Squarize (364756)

“…<p>Primary cultures of keratinocytes isolated from control and K14Cre <i>Pten</i>^F/F mice were treated with vehicle or rapamycin (50 nM), as indicated. Data are representative of three independent experiments performed in triplicate. …”

Data_Sheet_1_The Impact of Frequency Scale on the Response Sensitivity and Reliability of Cortical Neurons to 1/fβ Input Signals.PDF by Guojie Qu (6943781)

“…As the cutoff frequency is progressively increased from 50 to 1,000 Hz, the neuronal responsiveness increased gradually for 1/f noise, while decreased exponentially for white noise. …”

Confirmation of the Time-Off-Pick (TOP) phenotype using established body bend readout. by Alyssa C. Walker (10756726)

“…<p><b>A)</b> Age-dependent decline in motility assessed by increased TOP (left) and decreased number of body bends per 30 seconds (right) in muscle-specific polyQ35 (AM140), muscle-specific polyQ40 (AM141), and control (N2) worms. …”

Image 1_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le... by Ting Yang (189879)

“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”

Image 4_Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) le... by Ting Yang (189879)

“…<p>Optimizing fermentation duration is critical for producing high-quality cigar tobacco leaves This study examines changes in microorganisms and metabolites during CTL fermentation at four time points: 0 days (T0), 25 days (T1), 50 days (T2), and 75 days (T3). We observed a decreasing trend in total soluble sugars, starch, total nitrogen, and nicotine levels as fermentation progressed. …”

Supplementary Material for: Reduced DEFA5 expression and STAT3 activation underlie the submucosal invasion of early gastric cancers by Nagao S. (16545405)

“…To validate the findings of gene expression analysis and to examine the gene expression pattern in tissues, immunohistochemical (IHC) staining was performed for 50 cases of IMGC and SMGC each. Results Gene expression analysis demonstrated that the expression levels of small intestine-specific genes were significantly decreased in SMGC. …”

DataSheet1_Benefits, equity, and sustainability of community rainwater harvesting structures: An assessment based on farm scale social survey.docx by Mohammad Faiz Alam (14193893)

“…This is because of limited runoff and no carryover of stored groundwater, due to underlying shallow hard rock aquifer with little primary porosity, from wet years to dry years. Overall, ∼ 40%–50% of sampled farmers reported no benefits from CDs and the benefits decreased with distance. …”

Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells by Mohamed Qasim, Al-Fahdawi

“…Pt/MgO nanoparticles were cuboid and in the nanosize range of 30–50 nm. The cytotoxicity of Pt/MgO nanoparticles was determined via the 3-(4,5-dimethylthiazol-2-yl)−2,5-diphenyltetrazolium bromide assay on the human lung and colonic cancer cells (A549 and HT29 respectively) and normal human lung and colonic fibroblasts cells (MRC-5 and CCD-18Co repectively). …”
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Chlorophyll contents in the leaves of FNP and FP plants during senescence. by Liancheng Wu (359628)

“…<p>(A-C) Chlorophyll levels decreased over time in both treatments at different rates. …”

Significant pathway enrichments in squirrel forebrain for two primary hierarchical clusters. by Allyson G. Hindle (443743)

“…Enrichment score gives the mean <i>p</i>-value among members of each annotation cluster (negative log). …”

Data Sheet 1_Quantifying the spatial patterns of retinal ganglion cell loss and progression in optic neuropathy by applying a deep learning variational autoencoder approach to opti... by Jui-Kai Wang (15426571)

“…</p>Results<p>Incorporating bLVs improved reconstruction accuracy, with the image-based root-mean-square error (RMSE) between input and reconstructed GCL thickness maps decreasing from 5.55 ± 2.29 µm (two dLVs only) to 4.02 ± 1.61 µm (two dLVs and eight bLVs). …”

<i>Ras</i> cells show myeloid differentiation upon cytarabine treatment. by Mona Meyer (257592)

“…Shown are the individual samples and the mean expression (p = 0.04).</p>…”

HPV oncoprotein expression is negatively regulated by increasing cell confluence and loss of EGFR/ERK signaling. by Adrian J. Luna (10024591)

“…<p>(A) Growth curves constructed by seeding 1.5x10⁶ cells in 21cm² plates and counting cells every 24h over 168h (n = 2; error bars = SD). …”