Data Sheet 1_TP53 and KRAS co-mutations are associated with worse outcomes in mucinous ovarian carcinomas.docx by Yingao Zhang (10690941)

“…On multivariable analysis, TP53/KRAS co-mutations were associated with decreased PFS (adjusted hazard ratio [aHR] 4.02, 95% confidence interval [CI] 1.46-12.5, p=0.01) and OS (aHR 21.4, 95% CI 4.28-156, p<0.001). …”

Essential model parameters. by Chayanit Mahasing (19688403)

“…In addition, we conducted a one-way sensitivity analysis by adjusting R0 from 1.8 to 3.0 in all scenarios (epidemic stage) and by decreasing the vaccination cost by 50% at the end of the first year to reflect the current policy direction to enhance domestic vaccine production. …”

Suppression of SIRT1 activity increases PGC-1α acetylation and coactivator activity. by Kazuhiko Higashida (351645)

“…<p>(A) Nicotinamide (Nic) decreases SIRT1 activity in C₂C₁₂ myotubes as evidenced by increased p53 acetylation and prevention of p53 deacetylation in response to resveratrol (RSV). …”

Mapping the Internal Recognition Surface of an Octanuclear Coordination Cage Using Guest Libraries by Simon Turega (1322268)

“…The highest association constant is <i>K</i> = 1.2 × 10⁶ M^–1 for cycloundecanone, whose volume is approximately 50% of the cavity volume; for larger C₁₂ and C₁₃ cyclic ketones, the association constant progressively decreases as the guests become too large. …”

Hydrogel Based 3-Dimensional (3D) System for Toxicity and High-Throughput (HTP) Analysis for Cultured Murine Ovarian Follicles by Hong Zhou (29614)

“…We observed partial follicle survival of 35% ± 3% (n = 80) in 0.01nM treatment and 48% ± 2% (n = 92) in 0.005nM, which we identified as the IC50 for secondary follicles. In summary, we established a 3D <i>in vitro</i> ovarian follicle culture system that could be used in an HTP approach to measure toxic effects on ovarian follicles.…”

S1 Graphical abstract - by Eduardo J. Aguilar-Rangel (18349662)

“…While the <i>amoA</i>-AOA: <i>amoA</i>-AOB ratio decreased from 9.8 in rainfed soils to 1.6 in soils irrigated for 100 years, indicating a favoring environment for AOB rather than AOA. …”

Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant <i>Staphylococcus aureus</i> (MRSA) by Alan Hibbitts (6818348)

“…However, co-delivery of cNLC-TFD with vancomycin reduced the MIC of vancomycin by over 50% in MSSA and resulted in significant decreases in viability compared with vancomycin alone in MRSA cultures. …”

Relevance of Baseline Viral Genetic Heterogeneity and Host Factors for Treatment Outcome Prediction in Hepatitis C Virus 1b-Infected Patients by Verónica Saludes (236184)

“…</p><p>Principal Findings</p><p>A multivariate discriminant predictive model was generated including the following variables in decreasing order of significance: the number of viral variants in the E1–E2 region, an amino acid substitution pattern in the viral core region, the <i>IL28B</i> polymorphism, serum GGT and ALT levels, and viral load. …”

Determination of gene expression signature for high microglia/macrophage infiltrate and association with cell-specific gene signatures and molecular subtypes. by Jane R. Engler (140558)

“…Each dot represents an individual patient tumor, red denotes tumors defined to have high numbers of microglia/macrophages (greater than 67.5 microglia/macrophages per 400× field), blue dots denote tumors defined to have low microglia/macrophage numbers (less than 44.6 microglia/macrophages per 400× field). A representative image of microglia/macrophage staining (Iba1) for each group is shown (scale bars = 50 µm). …”

The effect of adjuvant oral application of honey in the management of postoperative pain after tonsillectomy in adults: A pilot study by Katharina Geißler (2634643)

“…</p><p>Results</p><p>Average pain in activity in the control group was greater than 4 (NRS 4.4 ± 2.4) during the first five postoperative days, with a renewed increase in pain intensity on the fifth day (4.3 ± 2.5). …”

Evolved colonies demonstrate increased splicing efficiency that results in higher transcript levels and relieved stress. by Idan Frumkin (3122832)

“…These mutations did not occur in the intron 5′ donor, 3′ acceptor, or the branching point—suggesting that other positions of the intron and its vicinity are functional and may affect splicing. …”

Maternal exposure to intimate partner violence and breastfeeding practices in 51 low-income and middle-income countries: A population-based cross-sectional study by Rishi Caleyachetty (4420993)

“…Depending on specification, the sample size varied between 95,320 and 102,318 mother–infant dyads. The mean age of mothers was 27.5 years, and the prevalence of any lifetime exposure to IPV among mothers was 33.3% (27.6% for physical violence, 8.4% for sexual violence, and 16.4% for emotional violence). …”

Datasheet1_Multicenter review of a tadalafil suspension formulation for infants and children with pulmonary hypertension: A North American experience.pdf by David Edward Youssef (14501636)

“…Introduction<p>Phosphodiesterase type 5 (PDE5) inhibitors, with sildenafil the earliest among them, are widely used in the management of pediatric pulmonary arterial hypertension (PAH). …”

File S1 - <i>Trypanosoma cruzi</i> Evades the Protective Role of Interferon-Gamma-Signaling in Parasite-Infected Cells by Philipp Stahl (443447)

“…Cells were stimulated for 0 h, 6 h or 12 h with 5 ng/ml IFNγ in the presence or absence of <i>T. cruzi</i> infection (MOI 20), as indicated. …”

Polymorphism in the abundance of the 3’–genic piRNAs in R strains. by Sergei Ryazansky (586294)

“…Heatmap is sorted for decreasing RPKM count for 3' genic piRNA clusters in <i>Paris</i> strain. …”

Table_1_Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL).pdf by Stephanie L. Savelli (6669164)

“…Patients with thrombosis but without SLE (N = 126), and patients with SLE but without thrombosis (N = 182) had the greatest differences in mean protein levels of C3 (p = 2.6 × 10⁻⁶), C4 (p = 2.2 × 10⁻⁹) and ACLA-IgG (p = 1.2 × 10⁻⁵). …”

Data_Sheet_1_Association of high estimated glomerular filtration rate with risk of atrial fibrillation: a nationwide cohort study.docx by Min Kyoung Kang (3829759)

“…The study employed Kaplan–Meier survival curves and Cox proportional hazard models to evaluate the association between eGFR and AF occurrence.</p>Results<p>The mean age of subjects was 48.82 ± 10.08 years. Over a median follow-up of 9.58 years, 27,469 (1.04%) AF cases were identified. …”

Data_Sheet_1_Global and Historical Distribution of Clostridioides difficile in the Human Diet (1981–2019): Systematic Review and Meta-Analysis of 21886 Samples Reveal Sources of He... by Alexander Rodriguez-Palacios (8497572)

“…At the food-set level (n = 232, mean 12.9 g/sample, similar across regions p > 0.2; 95%CI = 9.7–16.2), the weighted prevalence ranged between 4.5% (95%CI = 3–6%; all studies) and 8% (95%CI = 7–8%; only CD-positive-studies). …”

Data_Sheet_1_Efficacy and safety of acupuncture in post-stroke constipation: a systematic review and meta-analysis.docx by Tianye Sun (16450713)

“…We found that acupuncture was superior to conventional treatment (CT) in improving total responder rate [risk ratio (RR): 1.16, 95% confidence interval (CI): 1.09 to 1.25, p < 0.0001], decreasing constipation symptom scores [standardized mean difference (SMD): -0.65, 95% CI: −0.83 to −0.46, p < 0.00001], increasing serum P substance (SP) levels (SMD: 1.92, 95% CI: 0.47 to 3.36, p = 0.009), reducing the time to first bowel movement (BM) (SMD: -1.19, 95% CI: −2.13 to −0.25, p = 0.01), and lowing serum vasoactive intestinal peptide (VIP) levels (SMD: –2.11, 95% CI: −3.83 to −0.38, p = 0.02). …”

Table_1_Association of high estimated glomerular filtration rate with risk of atrial fibrillation: a nationwide cohort study.xlsx by Min Kyoung Kang (3829759)

“…The study employed Kaplan–Meier survival curves and Cox proportional hazard models to evaluate the association between eGFR and AF occurrence.</p>Results<p>The mean age of subjects was 48.82 ± 10.08 years. Over a median follow-up of 9.58 years, 27,469 (1.04%) AF cases were identified. …”