Trichopsistides A and B: Two Highly Oxygenated Pentacyclic Polyketides with Promising Inhibitory Effects on the NF-κB Signaling Pathway from the Fungus <i>Trichoderma koningiopsis<... by Li Feng (77923)

“…Two highly oxygenated pentacyclic polyketides with two new carbon skeletons, trichopsistide A (<b>1</b>) and trichopsistide B (<b>2</b>), were isolated from the plant endophyte <i>Trichoderma koningiopsis</i> WZ-196 derived from the leaf of <i>Rubia podantha</i> Diels. …”

Foxp3 expression in wildtype mice with 8 weeks of <i>S</i>. <i>japonicum</i> infection. by Liaoxun Lu (179293)

Leucophore formation does not require Sox10 function but is repressed by Sox10 and Sox5 (A-H) 9 dpf. by Yusuke Nagao (546940)

“…(L) WT, n = 12; <i>sox5</i>^<i>-/-</i>, n = 20; <i>sox10a</i>^<i>-/-</i><i>;sox5</i>^<i>-/-</i>, n = 32; <i>sox10a</i>^<i>-/-</i><i>;sox10b</i>^<i>+/-</i><i>;sox5</i>^<i>-/-</i>, n = 23; <i>sox10a</i>^<i>-/-</i><i>;sox10b</i>^<i>-/-</i><i>;sox5</i>^<i>-/-</i>, n = 13. …”

Overexpression of H2B and H3 induced defective chromosome segregation during mitosis. by Ruixue Zhao (2744689)

Table_1_Guanidine acetic acid exhibited greater growth performance in younger (13–30 kg) than in older (30–50 kg) lambs under high-concentrate feedlotting pattern.docx by Wen-Juan Li (1444948)

“…In a brief, the results obtained in the present study suggested that GAA (UGAA and CGAA; 1 g/kg DM) could be applied to improve growth performance in younger (13–30 kg) instead of older (30–50 kg) lambs in high-concentrate feedlotting practice.…”

Discovery of PMSA Derivative <b>11</b> as a Novel Lead Compound for Therapeutic Treatment of Osteoporosis <i>In Vitro</i> and <i>In Vivo</i> by Zhihao Chen (513264)

“…Additionally, <b>11</b> blocked the formation of F-action belts and bone resorption in a concentration-dependent manner. Mechanistically, <b>11</b> decreased the expression of genes required for osteoclastogenesis by blocking NFATc1 translocation from the cytoplasm to nucleus. …”

Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus <i>Penicillium daleae</i> L3SO by Qing-Yuan Wang (11571890)

“…The hypothetical biosynthetic pathways for <b>1</b> and <b>2</b> were postulated and were supported by CRISPR/Cas9 genome editing results. Penidaleodiolide A (<b>1</b>) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.…”

Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors by Vincenzo Cantaluppi (92814)

“…In the non DGF group, NGAL discriminated between slow or immediate graft function and decreased more rapidly than serum creatinine. NGAL increased after Tac introduction, suggesting a role as marker of drug toxicity. …”

Dietary or gavaged TU-100 and the ginger component decrease enteropooling stimulated by anti-CD3 antibody treatment in specified pathogen free (SPF) and germ free (GF) C57Bl6 mice. by Nobuhiro Ueno (346397)

Spatial patterns of linear regressions of seasonal mean (JJA and MAM) variables to the PC1 of storm track density in JJA by Buwen Dong (557113)

Over expression of hnRNP A1 decreases and hnRNP F increases inclusion of exon 11 of an <i>INSR</i> minigene, whereas knockdown of endogenous hnRNP F and hnRNP A1 has the opposite e... by Indrani Talukdar (195204)

Data Sheet 2_Reducing ocular Demodex using petroleum jelly may alleviate dry eye syndrome, blepharitis, facial dermatoses, ocular and respiratory allergies, and decrease associated... by Diana E. Senior-Fletcher (22090340)

“…Mean yearly issues of anti-allergy and antimicrobial medicines reduced from 15.6 (range 8–25) to 1.8 (range 0–4), representing an 88.5% decrease for Volunteer 1 and from 5.8 (range 3–9) and 14.2 issues (range 9–24) to zero for both Volunteer 2 and Volunteer 13 respectively, representing 100% reductions in prescribing. …”

Data Sheet 1_Reducing ocular Demodex using petroleum jelly may alleviate dry eye syndrome, blepharitis, facial dermatoses, ocular and respiratory allergies, and decrease associated... by Diana E. Senior-Fletcher (22090340)

“…Mean yearly issues of anti-allergy and antimicrobial medicines reduced from 15.6 (range 8–25) to 1.8 (range 0–4), representing an 88.5% decrease for Volunteer 1 and from 5.8 (range 3–9) and 14.2 issues (range 9–24) to zero for both Volunteer 2 and Volunteer 13 respectively, representing 100% reductions in prescribing. …”

P8 inhibits KSHV lytic replication by targeting the RTA-OTUD4-USP7 complex. by Shaowei Wang (490684)

An mRNA hairpin formed between the <i>sigG</i> leader sequence and RBS significantly decreases P_<i>sigG</i><i>-lacZ</i> translation. by Elizabeth B. Mearls (5150810)

“…<b>(B)</b> Depiction of the <i>sigG</i> RBS-hairpin structure predicted to form in the <i>sigG</i> mRNA leader sequence. The 5’ end of the <i>sigG</i> mRNA (+1), the <i>sigG</i> core RBS, and native GTG (GUG) translation start codon are labeled. …”

AdV-ZFP-VEGF administration reduces apoptosis after SCI. by Sarah A. Figley (389639)

“…Values are mean ± SEM, n = 4/sham and injured control groups, n = 5/AdV-eGFP and AdV-ZFP-VEGF groups. …”

Quantitative analyses of Trpm5- and villin-positive cells in the thymus and urethra. by Junpei Yamashita (2583877)

“…Trpm5-positive cells were completely absent in the <i>Skn-1a</i>-/- urethral epithelium (8.0 ± 0.6 cells in wild-type and 0 cells in <i>Skn-1a</i>-/-), and the number of villin-positive cells tended to decrease in <i>Skn-1a</i>-/- mice compared to wild-type mice (57 ± 11 cells in wild-type and 34 ± 0.9 cells in <i>Skn-1a</i>-/-). …”

The <i>unc-85</i> mutation reduces chromatin H3. by Ruixue Zhao (2744689)

Table S4. Differential expression analysis of the transcriptome of WT and ΔpldA strains from The outer membrane phospholipase A is essential for membrane integrity and type III sec... by Xia Wang (36364)

Effects of ROCK inhibitors H-1152 and Y-27632 on TNF-induced MLC phosphorylation, actin and CL5 reorganization and the fall in TEER. by Paul R. Clark (714064)