Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth fact... by Bei Cao (141848)

“…Coadministration of itraconazole increased the AUC_0-inf of limertinib by 289.8% (GLSM ratio, 389.8%; 90% CI, 334.07–454.82), but decreased that of CCB4580030 by 35.96% (GLSM ratio, 64.04%; 90% CI, 50.78–80.77).…”

Tat enhances vIL-6-induced angiogenesis and tumorigenesis through inactivation of PTEN and GSK-3β signals in CAM model. by Feng Zhou (76988)

“…The quantification of blood vessels was expressed as the mean ± SD (n = 5 to 8). (<b>E</b>) Overexpression of GSK-3β decreased the promoted effect of Tat on vIL-6-mediated tumorigenesis. 4E3 cells were treated as in (D). …”

Tubulin modifications and gamma-tubulin distribution in the tegument. by Inés Guarnaschelli (18102211)

Image 1_A comprehensive immune repertoire signature distinguishes pulmonary infiltration in SARS-CoV-2 Omicron variant infection.jpeg by Xuechuan Li (14430114)

“…</p>Results<p>Patients with pulmonary infiltration exhibit lymphopenia, a decreased proportion of the overall TCR repertoire alongside an increased BCR repertoire, reduced IGHD and IGHM isotype expression, a shorter mean CDR3 length for TRG, and a longer mean length for TRD, as well as diminished clonality and diversity in the TCR/BCR repertoire. …”

GluN2A(D731N) enhances sensitivity to endogenous proton and zinc ions. by Kai Gao (120150)

“…<p>(<b>A</b>) The composite proton concentration-response curves show an enhanced sensitivity of the GluN2A(D731N)-containing receptors to proton compared to the WT NMDA receptors; the abscissa shows hydrogen ion activity. …”

Effects of conivaptan on brain water content (BWC), blood-brain-barrier (BBB) disruption, plasma and urine sodium and osmolality. by Emil Zeynalov (596088)

“…Following MCAO, Evans Blue (EB) extravasation index (I/C) was increased in vehicle treated mice, and reduced in conivaptan treated mice, naïve, n = 5, vehicle, n = 8, Conivaptan 0.2 mg, n = 8. (C, D) Conivaptan treatment of 0.2 mg resulted in an elevation of plasma sodium and osmolality, and decreased urine sodium and osmolality due to aquaresis. …”

Smoking impact on fibrosis and cancer gene expression. by Lorise C. Gahring (271630)

“…Even at this low magnification the increased dysplasia of the bronchial lining is visible (asterisks). Bar = 50 microns. B. Plots show the relative expression of selected pro-fibrotic genes in the α7^G or the α7^E260A:G and the relative impact of either LPS (from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.ref007" target="_blank">7</a>]) or CS (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.t002" target="_blank">Table 2</a>). …”

Changes to distal lung structure of both α7 genotypes with and without CS exposure. by Lorise C. Gahring (271630)

“…In these representative sections the arrows point to AMs and in the α7^E260A:G arrow heads identify regions of increased cellularity that produce alveolar sacs of decreased size. …”

Expression levels of <i>Alox15</i>, <i>Hmox1</i> and <i>Fth1</i> in pulmonary myeloid cell populations. by Emilie Pollenus (10147748)

Histological staining. by Zahra Khalajzeyqami (6865475)

S1 Data - by Xiaoguang Zhang (1397257)

The change in mean annual densities of Amakihi at mid-elevation due to the translocation of disease-resistant Amakihi as a function of larval carrying capacity and density of infec... by Peter H. F. Hobbelen (298146)

“…The other climate scenarios are derived from this scenario by increasing or decreasing the daily temperatures and rainfall. The mean annual temperatures and average yearly amounts of rainfall for these scenarios are 15.5°C and 3000 mm (t−), 18.5°C and 3000 mm (t+), 17°C and 2000 mm (r−) and 17°C and 4000 mm (r+). …”

Fig 1 - by Leila Vahdatiraad (17382718)

Scores of each variable in the main components. by Leila Vahdatiraad (17382718)

“…Stellate sturgeon (<i>Acipenser stellatus</i>) fry, was exposed to diazinon (25, 50, and 75% of 96h-LC₅₀) for 6 days after pre-treatment with an HSP inducer (HSPi), TEX-OE^® (a prickly pear cactus extract), for 4 hours. …”

Effect of irradiation on GFAP immunostaining in mouse astroglia cells. by Nikolett Sándor (659792)

Graphic representation of the relation between the mean values of alveolar volume, calculated by the quintile method, and those of the corresponding DLCO, in healthy individuals (p... by Renato Prediletto (86307)

Uniform loss of type 3 OFF and 5 ON cone bipolar cells across <i>rd1</i> retinas over age. by Miao Chen (213356)

“…The density of cabp5 positive cells was decreased with age (<b>A</b>, <b>B</b>). …”

Effect of irradiation on claudin-5 immunostaining in mouse brain endothelial cells. by Nikolett Sándor (659792)

Effects of ischemia on the levels of mitochondrial fission proteins. by Gonçalo C. Pereira (9022700)

Glia-targeted 5-HT_2A receptor expression in adults reopens experience-dependent synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…There is a significant decrease in the Or42a OSN innervation volume with glial-targeted <i>Gal80</i>^<i>ts</i><i>-5-HT</i>_<i>2A</i><i>R</i> OE at 28°C (<i>n</i> = 20/condition, <i>p</i> = 1.00 × 10⁻¹⁵). …”